Perfil biográfico
Academic degrees:
- Graduation in Chemical Engineering, IST, Technical University of Lisbon
- PhD in Materials Science and Engineering, University of Aveiro, Jan 1988
Interesses científicos
-Chemical synthesis of nano and micro-sized calcium phosphate particles for biomedical applications;
- Preparation and characterization of porous scaffolds (polymer/ceramic composites) for biomedical applications;
- Drug releasing systems and composite scaffolds for regenerative medicine and tissue engineering.
Publicações seleccionadas
Santos C, Gomes PS, Duarte JA, Franke RP, Almeida MM, Costa MEV, Fernandes MH (2012) “ Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response”, J.R.Soc.Interface, Vol 9 / nº 7, 3397-3410
Petrauskaite O, Liesiene J, Santos C, Gomes PS, Garcia M, Fernandes MH, Almeida MM, Costa MEV, Juodzbalys G, Daugela P, Nano-Hydroxyapatite/Cellulose composite scaffold for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 6, (2012) 34-34.
Computational study of hydroxyapatite properties and surface interactions, A V.Bystrov, E.Costa, C.Santos, M.M.Almeida, A.Kholkin, S.Kopyl, YDekhtyar, A.V.Bystrova, E.V.Paramonova, Proc. of Joint Symposium ISAF/ECAPD/PFM 2012, pp 1-3
Endres S, Hiebl B, Hagele J, Beltzer C, Fuhrmann R, Jager V, Almeida M, Costa E, Santos C Traupe H, Jung EM, Prantl L, Wilke A, Franke RP (2011) "Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells”, Clinical Hemorheology and Microcirculation, 48, 29-40.
C.Santos, M. M Almeida, M.E.V. Costa , “Synthesis and characterization of amino-acid funcionalized hydroxyapatite nanoparticles” Cells and Materials, 2010, 20, 3, 223-223
C.Santos, M.A. Martins, M.M. Almeida and M.E.V. Costa, Influence of the (citric acid/ calcium) ratio on hap particles synthesis, Microscopy and Microanalysis, 15 (2009)85-86
- C.Santos, M.A. Martins, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Calcium phosphate granules for use as a 5-Fluorouracil delivery system", Ceramics International, 35 (2009) 1587-1594
C.Santos, C.F. Rovath, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system", Ceramics International, 35(2009)509-513
- T. Scharnweber, J. Fink, R. Fuhrmann, C. Santos, M.M. Almeida, M.E.V. Costa, R.-P. Franke, “Tissue engineering with calcium phosphate composite scaffolds”, Clinical Hemorheology and Microcirculation, 2009, 42, 169
- B. Hiebl, R. Fuhrmann, M.E.V. Costa, M.M. Almeida, R.P. Franke, "In vitro 3D assay to test angiogenic effects of human CD 14+ monocytes seeded on macroporous PLGA/CaP polymers with a CaP nanostructured surface", Clinical Hemorheology and Microcirculation, 40(1) (2008) 37-50
- Tim Scharnweber, Catarina Santos, Ralf-Peter Franke, Maria Margarida Almeida and Maria Elisabete Veira Costa, "Influence of spray-dried hydroxyapatite-5-Fluorouracil granules on cell lines derived from tissues of mesenchymal origin”, Molecules 13, (2008) 2729-2739
- C.Santos, R.-P. Franke, M.M. Almeida and M.E.V. Costa, “Nanoscale Characterization of Hydroxyapatite Particles by Electron Microscopy”, Microscopy and Microanalysis,14(2008)67-70
- M A. Martins, C. Santos, M. M. Almeida, M. E. V. Costa, “Hydroxyapatite micro- and nano-particles: nucleation and growth mechanisms in the presence of citrate species”,Journal of Colloids and Interface Science, (2008), 318, 2, 210-216.
- C.Santos, R.-P. Franke, M.M. Almeida, M.E.V. Costa and M.H. Fernandes “Viability and proliferation of MG-63 osteoblastic cells exposed to hydroxyapatite nanoparticles with different characteristics”, Tissue Engineering Part A, (2008), 14, 5, 810-810.
- R.-P. Franke, M.M. Almeida, M.E.V. Costa, C. Santos, V. Jaeger; A. Wike; R. Fuhrman, “Bridging Critical size defects applying tissue engineering”, Tissue Engineering Part A, (2008),14, 5, 816-816.
R.-P. Franke, C. Santos, T Scharnweber, M. M. Almeida and M. E. V. Costa, “Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells”, Basic & Clinical Pharmacology & toxicology, (2007), 101, 5, 360-360.
Projectos
Catalisadores Celulares òxidos para Combustão Limpa em meios Porosos (LEANCOMB)
ParticipanteFundação para a Ciência e a Tecnologia
cellular ceramics, combustion, catalysts, functionalizationDesenvolvimento de novas peças em grés com maior valor acrescentado através de processos mais sustentáveis (M2GRES2)
ParticipanteIndustry National
Long Lasting reinforced Concrete for Energy Infrastructure under Severe Operating (LORCENIS)
ParticipanteEuropean Comission
The main goal of the LORCENIS project is to develop long reinforced concrete for energy infrastructures with lifetime extended up to a 100% under extreme operating conditions. The concept is based on an optimal combinationof novel technologies involving customized methodologies for cost-efficient operation. 4 scenarios of severe oper...M2GRÉS - Grés utilitário de elevado desempenhoao nivel do metal-marking, a custo reduzido e em monocozedura (M2GRÉS)
ParticipanteIndustry National
O projeto M2Grés - Grés utilitário de elevado desempenho ao nível do metal-marking, a custo reduzido e em monocozedura?, promovido pelo consórcio constituído pela empresa Ria Stone e pelo Centro de Investigação em Materiais Cerâmicos e Compósitos da Universidade de Aveiro (CICECO) tem como objetivo o desenvolvimento de uma nova linha de peças em...NEWGEN - New Generation Biomimetic and Customized Implants for Bone Engineering (NEWGEN)
ParticipanteEuropean Comission
This COST Action, NEWGEN, aims at creating the seed for the European research and industry collaboration, combining basic knowledge from academic laboratories, R&D centres, medical units from hospitals, and a significant number of companies.With a predicted ageing population and increasing expectations regarding quality o...Revestimento de Particulas de WC com Aço Inox por Pulverização Catódica (POCTI/CTM/35460/1999)
ParticipanteFundação para a Ciência e a Tecnologia
revestimento de pós compósitos pulverização catódica carboneto de tungsténioTISSUE REACTOR - Development of a Bioreactor-Based Connective Tissue Production Line (TISSUE REACTOR)
Coordenador LocalEuropean Comission
It is the aim of this project to engineer connective tissue in vitro and to demonstrate its applicability as a tissue substitute in vivo. To achieve this goal a continuous cultivation process based on a perfused fixed-bed bioreactor system and its components will be developed which allows the production of large quantities of three-dimensional (...Publicações
Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphate spray-dried granules for bone tissue applications
Pinto, RV; Gomes, PS; Fernandes, MH; Costa, MEV; Almeida, MM
2020, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 109.
ISBN:
1873-0191
Effect of Fe2O3 doping on colour and mechanical properties of Y-TZP ceramics
Holz, L; Macias, J; Vitorino, N; Fernandes, AJS; Costa, FM; Almeida, MM
2018, CERAMICS INTERNATIONAL, 44, 15, 17962-17971.
Development and characterization of zirconia-alumina composites for orthopedic implants
Sequeira, S; Fernandes, MH; Neves, N; Almeida, MM
2017, CERAMICS INTERNATIONAL, 43, 1, 693-703.
ISBN:
1873-3956
Development of hydroxyapatite nanoparticles loaded with folic acid to induce osteoblastic differentiation
Santos, C; Gomes, P; Duarte, JA; Almeida, MM; Costa, MEV; Fernandes, MH
2017, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 516, 01-Feb, 185-195.
ISBN:
1873-3476
Recycling liquid effluents in a ceramic industry
de Almeida, BA; Almeida, M; Martins, S; Macarico, VA; da Fonseca, AT
2016, BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO, 55, 3, 95-104.
Morphological Evolution of Hydroxyapatite Particles in the Presence of Different Citrate:Calcium Ratios
Santos, C; Almeida, MM; Costa, ME
2015, CRYSTAL GROWTH & DESIGN, 15, 9, 4417-4426.
Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications
dos Santos, CF; Gomes, PS; Almeida, MM; Willinger, MG; Franke, RP; Fernandes, MH; Costa, ME
2015, RSC ADVANCES, 5, 85, 69184-69195.
Complex Effect of Hydroxyapatite Nanoparticles on the Differentiation and Functional Activity of Human Pre-Osteoclastic Cells
Costa-Rodrigues, J; Silva, A; Santos, C; Almeida, MM; Costa, ME; Fernandes, MH
2014, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 10, 12, 3590-3600.
A Computational Study of the Properties and Surface Interactions of Hydroxyapatite
Bystrov, VS; Paramonova, EV; Costa, MEV; Santos, C; Almeida, M; Kopyl, S; Dekhtyar, Y; Bystrova, AV; Maevsky, EI; Pullar, RC; Kholkin, AL
2013, FERROELECTRICS, 449, 1, 94-101.
Nano-Hydroxyapatite/Cellulose composite scaffold for bone tissue engineering
Petrauskaite, O; Liesiene, J; Santos, C; Gomes, PS; Garcia, M; Fernandes, MH; Almeida, MM; Costa, MEV; Juodzbalys, G; Daugela, P
2012, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 34-34.
Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response
Santos, C; Gomes, PS; Duarte, JA; Franke, RP; Almeida, MM; Costa, MEV; Fernandes, MH
2012, JOURNAL OF THE ROYAL SOCIETY INTERFACE, 9, 77, 3397-3410.
Behavior of co-cultures of human osteoblastic and osteoclastic cells in the presence of hydroxyapatite nanoparticles
Costa-Rodrigues, J; Silva, AI; Santos, C; Almeida, MM; Costa, MEV; Fernandes, MH
2011, BONE, 48, S131-S131.
Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells
Endres, S; Hiebl, B; Hagele, J; Beltzer, C; Fuhrmann, R; Jager, V; Almeida, M; Costa, E; Santos, C; Traupe, H; Jung, EM; Prantl, L; Jung, F; Wilke, A; Franke, RP
2011, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 48, 1-3, 29-40.
Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system
Santos, C; Rovath, CF; Franke, RP; Almeida, MM; Costa, MEV
2009, CERAMICS INTERNATIONAL, 35, 1, 509-513.
Calcium phosphate granules for use as a 5-Fluorouracil delivery system
Santos, C; Martins, MA; Franke, RP; Almeida, MM; Costa, MEV
2009, CERAMICS INTERNATIONAL, 35, 4, 1587-1594.
Behaviour of osteoblastic-like MG-63 cells cultured with hydroxyapatite and biphasic (Hap/beta-Tcp) porous granules
Santos, C; Franke, RP; Almeida, MM; Costa, MEV; Fernandes, MH
2008, TISSUE ENGINEERING PART A, 14, 5, 810-810.
Nanoscale Characterization of Hydroxyapatite Particles by Electron Microscopy
Santos, C; Franke, RP; Almeida, MM; Costa, MEV
2008, MICROSCOPY AND MICROANALYSIS, 14, 67-70.
In vitro 3D assay to test angiogenic effects of human CD14+ positive monocytes seeded on macroporous PLGA/CaP polymers with a CaP nanostructured surface (vol 40, pg 37, 2008)
Hiebl, B; Fuhrmann, R; Costa, MEV; Almeida, MM; Franke, RP
2008, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 40, 4, 327-327.
Influence of Spray-dried Hydroxyapatite-5-Fluorouracil Granules on Cell Lines Derived from Tissues of Mesenchymal Origin
Scharnweber, T; Santos, C; Franke, RP; Almeida, MM; Costa, MEV
2008, MOLECULES, 13, 11, 2729-2739.
Hydroxyapatite micro- and nanoparticles: Nucleation and growth mechanisms in the presence of citrate species
Martins, MA; Santos, C; Almeida, MM; Costa, MEV
2008, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 318, 2, 210-216.
Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells
Franke, RP; Santos, C; Scharnweber, T; Almeida, MM; Costa, MEV
2007, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 101, 5, 360-360.
Preparation and characterization of chitosan-based scaffolds for biomedical applications
Araujo, JV; Lopes-Da-Silva, JA; Almeida, MM; Costa, MEV
2006, ADVANCED MATERIALS FORUM III, PTS 1 AND 2, 514-516, 1005-1009.
Adsorption mechanism of 5-flourouracil on different hydroxyapatite particles
Santos, C; Martins, MA; Almeida, MM; Costa, MEV
2006, ADVANCED MATERIALS FORUM III, PTS 1 AND 2, 514-516, 1103-1107.
Preparation of porous hydroxyapatite particles to be used as drug delivery systems
Martins, MA; Santos, C; Costa, MEV; Almeida, MM
2004, ADVANCED MATERIALS FORUM II, 455-456, 353-357.
ISBN:
0-87849-941-5
Effect of the enzyme concentration on the DIRECT coagulation casting of hydroxyapatite-alumina bodies
Rolo, A; Tavares, A; Senos, AMR; Almeida, M
2004, ADVANCED MATERIALS FORUM II, 455-456, 366-369.
ISBN:
0-87849-941-5