Maria Margarida Tavares Lopes Almeida

Emeritus Professor

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Department

  • Materials and Ceramic Engineering

Research

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Short CV

Academic degrees:

   - Graduation in Chemical Engineering, IST, Technical University of Lisbon

   - PhD in Materials Science and Engineering, University of Aveiro, Jan 1988

 

Scientific Interests

-Chemical synthesis of nano and micro-sized calcium phosphate particles for biomedical applications;

- Preparation and characterization of porous scaffolds (polymer/ceramic composites) for biomedical applications;

- Drug releasing systems and composite scaffolds for regenerative medicine and tissue engineering.

Selected Publications

Santos C, Gomes PS, Duarte JA, Franke RP, Almeida MM, Costa MEV, Fernandes MH (2012) “ Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response”, J.R.Soc.Interface, Vol 9 / nº 7, 3397-3410

Petrauskaite O, Liesiene J, Santos C, Gomes PS,  Garcia M,  Fernandes MH, Almeida MM, Costa MEV, Juodzbalys G, Daugela P,  Nano-Hydroxyapatite/Cellulose composite scaffold for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 6, (2012) 34-34.

Computational study of hydroxyapatite properties and surface interactions, A V.Bystrov, E.Costa, C.Santos, M.M.Almeida, A.Kholkin, S.Kopyl, YDekhtyar, A.V.Bystrova, E.V.Paramonova, Proc. of Joint Symposium  ISAF/ECAPD/PFM 2012, pp 1-3

Endres S, Hiebl B, Hagele J, Beltzer C, Fuhrmann R, Jager V, Almeida M, Costa E, Santos C Traupe H, Jung EM, Prantl L, Wilke A, Franke RP (2011)  "Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells”, Clinical Hemorheology and Microcirculation, 48, 29-40.

C.Santos, M. M Almeida, M.E.V. Costa , “Synthesis and characterization of amino-acid funcionalized hydroxyapatite nanoparticles” Cells and Materials, 2010, 20, 3, 223-223

C.Santos, M.A. Martins, M.M. Almeida and M.E.V. Costa, Influence of the (citric acid/ calcium) ratio on hap particles synthesis, Microscopy and Microanalysis, 15 (2009)85-86

- C.Santos, M.A. Martins, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Calcium phosphate granules for use as a 5-Fluorouracil delivery system", Ceramics International, 35 (2009) 1587-1594

C.Santos, C.F. Rovath, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system", Ceramics International, 35(2009)509-513

- T. Scharnweber, J. Fink, R. Fuhrmann, C. Santos, M.M. Almeida, M.E.V. Costa, R.-P. Franke, “Tissue engineering with calcium phosphate composite scaffolds”, Clinical Hemorheology and Microcirculation, 2009, 42, 169

- B. Hiebl, R. Fuhrmann, M.E.V. Costa, M.M. Almeida, R.P. Franke, "In vitro 3D assay to test angiogenic effects of human CD 14+ monocytes seeded on macroporous PLGA/CaP polymers with a CaP nanostructured surface", Clinical Hemorheology and Microcirculation, 40(1) (2008) 37-50

- Tim Scharnweber, Catarina Santos, Ralf-Peter Franke, Maria Margarida Almeida and Maria Elisabete Veira Costa, "Influence of spray-dried hydroxyapatite-5-Fluorouracil granules on cell lines derived from tissues of mesenchymal origin”, Molecules 13, (2008) 2729-2739

- C.Santos, R.-P. Franke, M.M. Almeida and M.E.V. Costa, “Nanoscale Characterization of Hydroxyapatite Particles by Electron Microscopy”, Microscopy and Microanalysis,14(2008)67-70

- M A. Martins, C. Santos, M. M. Almeida, M. E. V. Costa, “Hydroxyapatite micro- and nano-particles: nucleation and growth mechanisms in the presence of citrate species”,Journal of Colloids and Interface Science, (2008), 318, 2, 210-216.

- C.Santos, R.-P. Franke, M.M. Almeida, M.E.V. Costa and M.H. Fernandes “Viability and proliferation of MG-63 osteoblastic cells exposed to hydroxyapatite nanoparticles with different characteristics”, Tissue Engineering Part A, (2008), 14, 5, 810-810.

- R.-P. Franke, M.M. Almeida, M.E.V. Costa, C. Santos, V. Jaeger; A. Wike; R. Fuhrman, “Bridging Critical size defects applying tissue engineering”, Tissue Engineering Part A, (2008),14, 5, 816-816.

R.-P. Franke, C. Santos, T Scharnweber, M. M. Almeida and M. E. V. Costa, “Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells”, Basic & Clinical Pharmacology & toxicology, (2007), 101, 5, 360-360.

 

Publications

Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphate spray-dried granules for bone tissue applications

Pinto, RV; Gomes, PS; Fernandes, MH; Costa, MEV; Almeida, MM
2020, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 109.
ISBN: 1873-0191

Effect of Fe2O3 doping on colour and mechanical properties of Y-TZP ceramics

Holz, L; Macias, J; Vitorino, N; Fernandes, AJS; Costa, FM; Almeida, MM
2018, CERAMICS INTERNATIONAL, 44, 15, 17962-17971.

Development and characterization of zirconia-alumina composites for orthopedic implants

Sequeira, S; Fernandes, MH; Neves, N; Almeida, MM
2017, CERAMICS INTERNATIONAL, 43, 1, 693-703.
ISBN: 1873-3956

Development of hydroxyapatite nanoparticles loaded with folic acid to induce osteoblastic differentiation

Santos, C; Gomes, P; Duarte, JA; Almeida, MM; Costa, MEV; Fernandes, MH
2017, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 516, 01-Feb, 185-195.
ISBN: 1873-3476

Recycling liquid effluents in a ceramic industry

de Almeida, BA; Almeida, M; Martins, S; Macarico, VA; da Fonseca, AT
2016, BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO, 55, 3, 95-104.

Morphological Evolution of Hydroxyapatite Particles in the Presence of Different Citrate:Calcium Ratios

Santos, C; Almeida, MM; Costa, ME
2015, CRYSTAL GROWTH & DESIGN, 15, 9, 4417-4426.

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

dos Santos, CF; Gomes, PS; Almeida, MM; Willinger, MG; Franke, RP; Fernandes, MH; Costa, ME
2015, RSC ADVANCES, 5, 85, 69184-69195.

Complex Effect of Hydroxyapatite Nanoparticles on the Differentiation and Functional Activity of Human Pre-Osteoclastic Cells

Costa-Rodrigues, J; Silva, A; Santos, C; Almeida, MM; Costa, ME; Fernandes, MH
2014, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 10, 12, 3590-3600.

A Computational Study of the Properties and Surface Interactions of Hydroxyapatite

Bystrov, VS; Paramonova, EV; Costa, MEV; Santos, C; Almeida, M; Kopyl, S; Dekhtyar, Y; Bystrova, AV; Maevsky, EI; Pullar, RC; Kholkin, AL
2013, FERROELECTRICS, 449, 1, 94-101.

Nano-Hydroxyapatite/Cellulose composite scaffold for bone tissue engineering

Petrauskaite, O; Liesiene, J; Santos, C; Gomes, PS; Garcia, M; Fernandes, MH; Almeida, MM; Costa, MEV; Juodzbalys, G; Daugela, P
2012, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 34-34.

Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response

Santos, C; Gomes, PS; Duarte, JA; Franke, RP; Almeida, MM; Costa, MEV; Fernandes, MH
2012, JOURNAL OF THE ROYAL SOCIETY INTERFACE, 9, 77, 3397-3410.

Behavior of co-cultures of human osteoblastic and osteoclastic cells in the presence of hydroxyapatite nanoparticles

Costa-Rodrigues, J; Silva, AI; Santos, C; Almeida, MM; Costa, MEV; Fernandes, MH
2011, BONE, 48, S131-S131.

Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells

Endres, S; Hiebl, B; Hagele, J; Beltzer, C; Fuhrmann, R; Jager, V; Almeida, M; Costa, E; Santos, C; Traupe, H; Jung, EM; Prantl, L; Jung, F; Wilke, A; Franke, RP
2011, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 48, 1-3, 29-40.

Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system

Santos, C; Rovath, CF; Franke, RP; Almeida, MM; Costa, MEV
2009, CERAMICS INTERNATIONAL, 35, 1, 509-513.

Calcium phosphate granules for use as a 5-Fluorouracil delivery system

Santos, C; Martins, MA; Franke, RP; Almeida, MM; Costa, MEV
2009, CERAMICS INTERNATIONAL, 35, 4, 1587-1594.

Behaviour of osteoblastic-like MG-63 cells cultured with hydroxyapatite and biphasic (Hap/beta-Tcp) porous granules

Santos, C; Franke, RP; Almeida, MM; Costa, MEV; Fernandes, MH
2008, TISSUE ENGINEERING PART A, 14, 5, 810-810.

Nanoscale Characterization of Hydroxyapatite Particles by Electron Microscopy

Santos, C; Franke, RP; Almeida, MM; Costa, MEV
2008, MICROSCOPY AND MICROANALYSIS, 14, 67-70.

In vitro 3D assay to test angiogenic effects of human CD14+ positive monocytes seeded on macroporous PLGA/CaP polymers with a CaP nanostructured surface (vol 40, pg 37, 2008)

Hiebl, B; Fuhrmann, R; Costa, MEV; Almeida, MM; Franke, RP
2008, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 40, 4, 327-327.

Influence of Spray-dried Hydroxyapatite-5-Fluorouracil Granules on Cell Lines Derived from Tissues of Mesenchymal Origin

Scharnweber, T; Santos, C; Franke, RP; Almeida, MM; Costa, MEV
2008, MOLECULES, 13, 11, 2729-2739.

Hydroxyapatite micro- and nanoparticles: Nucleation and growth mechanisms in the presence of citrate species

Martins, MA; Santos, C; Almeida, MM; Costa, MEV
2008, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 318, 2, 210-216.

Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells

Franke, RP; Santos, C; Scharnweber, T; Almeida, MM; Costa, MEV
2007, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 101, 5, 360-360.

Preparation and characterization of chitosan-based scaffolds for biomedical applications

Araujo, JV; Lopes-Da-Silva, JA; Almeida, MM; Costa, MEV
2006, ADVANCED MATERIALS FORUM III, PTS 1 AND 2, 514-516, 1005-1009.

Adsorption mechanism of 5-flourouracil on different hydroxyapatite particles

Santos, C; Martins, MA; Almeida, MM; Costa, MEV
2006, ADVANCED MATERIALS FORUM III, PTS 1 AND 2, 514-516, 1103-1107.

Preparation of porous hydroxyapatite particles to be used as drug delivery systems

Martins, MA; Santos, C; Costa, MEV; Almeida, MM
2004, ADVANCED MATERIALS FORUM II, 455-456, 353-357.
ISBN: 0-87849-941-5

Effect of the enzyme concentration on the DIRECT coagulation casting of hydroxyapatite-alumina bodies

Rolo, A; Tavares, A; Senos, AMR; Almeida, M
2004, ADVANCED MATERIALS FORUM II, 455-456, 366-369.
ISBN: 0-87849-941-5

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