Ana Maria Pissarra Coelho Gil

Professor Associado com Agregação

Contacto

Departamento

  • Química
  • 29.2.42

Investigação

Ligações

Últimas Notícias

Perfil biográfico

2007: Provas de Agregação sobre o tema “A análise de misturas complexas por espectroscopia de Ressonância Magnética Nuclear (RMN): princípios e aplicações”, Departamento de Química, Universidade de Aveiro, Janeiro de 2007.
1992: Doutoramento em Química, desenvolvido na Universidade de East Anglia, U.K., e terminado em Outubro de 1992. A tese produzida intitulou-se "Spectroscopic Studies of Proteins in the Solid State".
1990: Provas de Aptidão Pedagógica e Capacidade Científica sobre os temas "Gelificação de Polissacarídeos: estudo do efeito de iões por métodos físico-químicos" e "Estudos de Polissacarídeos Sulfatados por FT-IR".
1987: Licenciatura em Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal, completada em Outubro de 1987 com a nota final de 17 valores.

 

 

Interesses científicos

Os interesses de investigação listam-se, por ordem aproximadamente evolutiva, do seguinte modo:
• Caracterização estrutural de proteínas purificadas de cereais para a compreensão das suas propriedades viscoelásticas.
• Estudos estruturais de cortiça e outros materiais lignocelulósicos.
• Estudos estruturais e dinâmicos de mono- e oligossacarídeos no estado sólido.
• Desenvolvimento de técnicas de Rheo-NMR para o estudo de propriedades reológicas e sua interpretação ao nível molecular.
• Estudo estrutural e dinâmico de geles de polissacarídeos.
• Estudos espectroscópicos da composição e alterações bioquímicas de frutos e sumos de fruta.
• Desenvolvimentos de métodos analíticos rápidos fazendo uso de RMN do estado líquido e do estado sólido, FTIR e quimiometria, por exemplo, métodos para implementação prática em análise de cervejas e detecção de contaminação microbiológica em sumos.
• Análise de biofluidos e tecidos biológicos para caracterização bioquímica de doenças e seu diagnóstico precoce.
• Desenvolvimento de novos biomateriais e avaliação do seu desempenho ex-vivo e in vivo.

Grupo de Investigação

Doutorandos:

1. Gonçalo Graça, bolsa FCT SFRH/BD/41869/2007 Janeiro 2008 – Dezembro 2011, Doutoramento sobre “Novos métodos de diagnóstico pré-natal com base em espectroscopia de RMN” (co-supervisão)
2. João Aleixo Rodrigues, bolsa FCT SFRH/BD/31056/2006, Outubro 2006-Setembro 2009, Doutoramento sobre “Desenvolvimento de métodos de Espectroscopia de Ressonância Magnética Nuclear (RMN) para o controlo da qualidade da cerveja e seu processo de fabrico” (co-supervisão)
3. Sílvia de Oliveira Diaz, bolsa FCT SFRH/BD/64159/2009,Doutoramento sobre “Metabonomics of urine and plasma for pregnancy monitoring and prediction of disorders of the mother, foetus and newborn, Janeiro 2010- Dezembro 2013 (co-supervisão)
4. Inês Lamego, bolsa FCT SFRH/BD/63916/2009, Doutoramento sobre “Suportes implantáveis para quimioterapia localizada do osteossarcoma", Janeiro 2010-Dezembro 2013

Mestrandos:
1. Joana Pinto, aluna do Mestrado em "Advanced Biomolecular Methods", Setembro 2008-Junho 2010

Outros:
1. Ana Sofia Moreira, bolsa de integração na investigação, Outubro 2008 - Dezembro 2009
2. Diogo Pinho, bolsa de integração na investigação (co-supervisão), Outubro 2009-Dezembro 2010

Principais colaboradores

Faculdade de Medicina, Imperial College of Science, Londres, UK
Departamento de Química, Universidade de Warwick, UK
Laboratoire de Chimie, Ecole Normale Superieure de Lyon (ENSL), França
Bruker Biospin GmbH, Alemanha
Faculdade de Medicina da Universidade de Coimbra, Centro de Neurociencias e Biologia Celular-CNC, Universidade de Coimbra, Portugal
Maternidade Bissaya Barreto, Coimbra, Portugal
Centro Hospitalar de Gaia, Portugal
Universidade de Turku, Finlândia

Actividade pedagógica

Mestrados:
• Segurança e Qualidade Alimentar (2009-2010) do Mestrado em Bioquímica Alimentar
• Técnicas Avançadas de Análise de Alimentos (2002/2003 e 2004/2005) do Mestrado de Química e Qualidade de Alimentos.
• Análise Estrutural e Técnicas de Análise (1995/1996) do Mestrado em Química dos Produtos Naturais e Alimentose Módulo de Ressonância Magnética Nuclear (1995/1996) do Mestrado em Engenharia de Materiais .
• Química de Colóides (1997/1998, 1999/2000 e 2001/2002) do curso de Mestrado em Química dos Produtos Naturais e Alimentos.

Licenciatura:
Laboratórios B2-B3 (2007-2010) do curso de Bioquímica
• Princípios de Bioquímica (2006-2007) do curso de Ensino de Física e Química
• Fundamentos de Bioquímica I (2006-2008, 2010) do curso de Psicologia
• Bioquímica I (2006-2008) dos cursos de Bioquímica e de Biotecnologia
• Segurança e Qualidade Alimentar (2002-2006) do curso de Química e Bioquímica Alimentar.
• Química I (1994-1997 e 2004-2005) dos cursos da Universidade de Aveiro, na qual leccionou aulas teóricas e teórico-praticas.
• Análise de Alimentos (1992-1997 e 2000-2001) do curso de Química - Ramo Química Alimentar.
• Aulas teórico-práticas das disciplinas de Estrutura e Propriedades da Matéria (1992-1993) e Química das Águas (1992-1993) dos cursos da Universidade de Aveiro.
• Aulas laboratoriais das disciplinas de Laboratórios de Química (1992-1994), Química Alimentar II (1993-1994), Bio-orgânica (1993-1994), Química I (1997-1998), Laboratórios QB716 (1997-2002), Laboratórios Q416 (1999-2002), Laboratórios Q626 (2001-2002) e Química II (2002-2004, 2006) dos cursos de Química da Universidade de Aveiro.
• Aulas laboratoriais e teórico-práticas das disciplinas de Química Geral I e II (1987-1988) e aulas teórico-práticas da disciplina de Termodinâmica (1987-1988) do curso de Engenharia Alimentar na Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Porto.

Projectos financiados

Presently ongoing projects:
1. 2014-2015: Principal Investigator in project on “Effects of environmental hazards of the Estarreja region on pregnancy metabolism”, funded by Observatório - OHMI Estarreja, € 8000, PI: University of Aveiro.
2. 2013-2015: Participant in project on “Biomaterials for Regenerative Medicine”, funded by QREN (human resources only), PI: University of Aveiro.
3. 2014-2016: Participant in project on "Age-related macular degeneration – can metabolomic profile distinguish progress ors?", Portuguese Science &Technology Foundation (HMSP-IC J/0006/2013), € 97.989,00, 1/7/2014-30/6/2016.
4. 2012-2015: Participant in project on “Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials”, funded by Fundação para a Ciência e Tecnologia (PTDC/SAU-TOX/120953/2010), € 152445 (total and UA), 16/4/12-30/3/15, PI: University of Aveiro.
5. 2012-2014: Participant in project on “ASTHMA: Future asthma management helped by non- evasive sampling: contributes for the definition of a rapid and non-evasive diagnostic tool”, funded by Fundação para a Ciência e Tecnologia (PTDC/QUI-QUI/117803/2010), € 79688 (total and UA), 1/1/12-31/12/14, PI: University of Aveiro.
6. 2011-2014: Participant in project on “The role of the intestine in promoting the lipogenic effects of fructose”, funded by Fundação para a Ciência e Tecnologia (PTDC/SAU-MET/111398/2009), € 159564 (€ 20088 for UA), PI: University of Coimbra.
7. 2012-2015: Participant in project on “Metabolic study of lung cancer and the surgical state: search for metabolic signatures in tissues and biofluids”, funded by CIMAGO, € 1750 3/12-2/15, PI: University of Aveiro.
8. 2012-2015: Participant in project on “Search for new biomarkers of the response of lung cancer to therapy”, funded by CIMAGO, € 1750 3/12-2/15, PI: University of Aveiro.

Previous projects:
1. 2011-2013: Principal Investigator in 2nd “Scientific Collaboration Agreement between University of Aveiro and Bruker Biospin GmbH on “Metabonomics applications in food analysis and in health”, € 8940 (human resources) and € 255,330 (software licensing).
2. 2008-2011: Participant in project on “Metabolic profiling and biochemical differentiation of human lung tumours by Nuclear Magnetic Resonance (NMR) methods” funded by Fundação para a Ciência e Tecnologia (PTDC/QUI/68017/2006), € 70600 (€ 59000UA), PI: University of Aveiro.
3. 2008-2011: Participant in project on "Nanochemistry of magnetic/luminescent composites for in vitro medical diagnosis applications" funded by Fundação para a Ciência e Tecnologia (PTDC/QUI/67712/2006), € 56200 (total and UA), PI: University of Aveiro.
4. 2007-2010: Principal investigator in project on "Metabonomic studies of prenatal disorders by NMR spectroscopy " funded by Fundação para a Ciência e Tecnologia(PTDC/QUI/66523/2006), € 75700 (€ 65000UA), 1/08-6/11, PI: University of Aveiro.
5. 2007-2010: Participant in project on "Implantable scaffolds for local osteo-sarcoma chemotherapy", funded by Fundação para a Ciência e Tecnologia (PTDC/SAU-BEB/66896/2006), € 161000 (€ 148000UA), PI: University of Aveiro.
6. 2007-2009: Principal Investigator in 1st “Scientific Collaboration Agreement between University of Aveiro and Bruker Biospin GmbH on “Metabonomics applications in food analysis and in health”, € 15745 (human resources, 1 year PhD student) and € 219,720 (software licensing).
7. 2005-2008: Principal investigator of project on “Actualização e expansão do laboratório de RMN da Universidade de Aveiro”, funded by “Fundação para a Ciência e Tecnologia” (CONC- REEQ/934/QUI/2005) (450000 euros) and by the University of Aveiro (45000 euros).
8. 2005-2006: Participant in project “Re-equipamento do Laboratório de Materiais Macromoleculares e Lenhocelulósicos da Universidade de Aveiro”, funded by “Fundação para a Ciência e Tecnologia” (CONC-REEQ/584/CTM/2005) (100.000 euros) and by the University of Aveiro (10.000 euros).
9. 2005-2008: Participant in project on “Mould proteome regulation by substrate bioavailability: depolymerising enzymes likely to alter biopolymer nanostructure.”, funded by Fundação para a Ciência e Tecnologia (POCI/QUI/56229/2004) 198000 euros (UA), PI: Instituto de Biologia Experimental e Tecnológica-Lisboa.
10. 2005-2006: Principal investigator in project on “Application of NMR spectroscopy for the chemical characterisation and quality control of beer”, funded by UNICER-Bebidas de Portugal, SGPS, SA (20425 euros for UA, PhD student start-up) and Bruker Biospin GmbH (2250 euros for UA).
11. 2003 – 2007: Principal investigator in project on “NMR and LC-NMR/MS methods for the study of biofluids and biological tissues”, funded by “Fundação para a Ciência e Tecnologia” (postdoc grant) and Treaty of Windsor programme (CRUP/British Council), Participants: University of Aveiro and Imperial College, Londres.
12. 2003-2005: Participant in project on “Cellulose: surface properties, interaction with binding domains and enzymatic modification” funded by FCT/POCTI/QUI/44368/2002, 4250 euros for UA, PI: University of Minho.
13. 2001-2004: Participant in project on "Structural and Functional Aspects of Bulk and Interfacial Polysaccharide-Surfactant Interactions in Food Colloids" funded by FCT (POCTI/BIO/33626/99), 139.660 euros (total and UA), PI: University of Aveiro.
14. 2003-2004: Participant in project on “Study of the viscoelastic properties of Flours: correlation between extensibility and chemical composition”, funded by CRUP/British Council.
15. 2001-2004: Principal investigator in project on “Structural studies of solid carbohydrates” funded by FCT (POCTI/QUI/33075/99) and co-funded by CRUP/British Council and Universidade de Aveiro (postdoc grant). Participants: University of Aveiro, University of Surrey and University of Warwick, UK, 37409 euros for UA.
16. 1998-2000: Principal investigator in project on "Structural and functional study of wheat floud and its derived foods" funded by PRAXIS XXI (PRAXIS/PCNA/BIO/0703/96), Participants: Universidade de Aveiro, Universidade do Porto, Instituto Superior de Agronomia e Estação Agronómica de Melhoramento de Plantas, Elvas, 21360 euros for UA.
17. 1997-2000: Participant in project on "From Eucalyptus globulus to paper: kraft pulp bleaching" funded by PRAXIS XXI (3/3.2/PAPEL/2326/95) and RAIZ.
18. 1997-2000: Participant on "From Eucalyptus globulus to paper: kraft pulping",funded by PRAXIS XXI (3/3.2/PAPEL/2327/95) and RAIZ.
19. 1996-1999: Participant in project on "Improving the quality of EU wheats for use in the food industry", funded by EC FAIR (Ref. CT96 1170) and co-funded by JNICT/British Council). Participants: IACR-Long Ashton Research Station-UK, Institute of Food Research-UK, Universidade de Groningen-NL, Universidade de Lund-SW, Universidade de Tuscia-IT, University of Aveiro-PT, Svalöf Weibull AB-SW, INRA-FR, Universidade de Catania-IT, IACR-Rothamsted- UK, 87434 euros for UA.
20. 1996-1999: Principal investigator in project on "Síntese e caracterização de peptídeos no estado sólido", funded by JNICT (Financiamento Plurianual) and Himeji Institute of Technology, Japan. Participants: Universidade de Aveiro and Himeji Institute of Technology, Japan.
21. 1994-1995: Principal investigator in project on "Spectroscopic Investigations of Cereal Proteins Quality", financiado por JNICT (Financiamento Plurianual) and Tratado de Windsor (JNICT/British Council). Participants: Universidade de Aveiro, Institute of Food Research and Universidade de Bristol.

Publicações seleccionadas

Artigos SCI nos últimos 5 anos:

  1. Graça G,Moreira AS, Vicente Correia AJ, Goodfellow BJ, Barros AS, Duarte IF,Carreira IM, Galhano E,Pita C, Almeida MC, Gil AM, “Mid-infrared (MIR) metabolic fingerprinting of amniotic fluid: a possible avenue for early diagnosis of prenatal disorders?” Analytica Chimica Acta, 764 24-31, 2013. doi:10.1016/j.aca.2012.12.023
  2. Diaz SD, Barros AS, Goodfellow BJ, Duarte IF, Carreira IC, Galhano E, Pita C, Almeida MC, Gil AM, “Following Healthy Pregnancy by Nuclear Magnetic Resonance (NMR) Metabolic Profiling of Human Urine”, Journal of Proteome Research, 12 969-979, 2013. doi: 10.1021/pr301022e
  3. Lehtonen H-M, Lindstedt A, Järvinen R, Sinkkonen J, Graça G, Viitanen M, Kallio H. Gil AM, “1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal”, Food Chemistry,138 (2-3), 982-990, 2013. doi: 10.1016/j.foodchem.2012.10.081* 
  4. Diaz S, Barros A, Goodfellow B, Duarte I, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes”, Journal of Proteome Research, 12(6), 2946-2957, 2013. doi:10.1021/pr4002355Cover of the June 2013 Issue.
  5. Duarte IF, Rocha CM, Gil AM, “Metabolic profiling of biofluids: potential in lung cancer screening and diagnosis” Expert Review of Molecular Diagnostics,13(7), 737–748, 2013. doi: 10.1586/14737159.2013.835570
  6. Duarte IF, Ladeirinha AF, Lamego IL, Gil AM, Carvalho L, Carreira IM, Melo JB, “Potential markers of cisplatin treatment response unveiled by NMR meabolomics of human lung cells”, Molecular Phamaceutics, 10(11),4242-4251, 2013.doi: 10.1021/mp400335k *
  7. Loureiro CC, Gomes J, Barros A, Gil AM, Carrola J, Duarte IF, Bousquet J, Todo-Bom A, Rocha SM, “Urinary metabolomic changes as a predictive biomarker of asthma exacerbation”,The Journal of Allergy and Clinical Immunology, 133 (1), 261-263.e5, 2014.doi:10.1016/j.jaci.2013.11.004 *
  8. Duarte IF, Diaz S, Gil AM, “NMR metabolomics of human blood and urine in disease research”, Journal of Pharmaceutical and Biomedical Analysis, 93, 17–26, 2014. doi: http://dx.doi.org/10.1016/j.jpba.2013.09.025
  9. Dias MC, Figueiredo P, Duarte I, Gil A, Santos C. "Differential response of young and expanded lettuce leaves to fungicide mancozeb: chlorophyll fluorescence, lipid peroxidation, pigments and proline content", Photosynthetica, 52(1), 148-151, 2014. doi:10.1007/s11099-014-0016-y *
  10. Lindstedt A, Järvinen R, Sinkkonen J, Lehtonen H-M, Graça G, Viitanen M, Gil AM, Kallio H, “Postprandial response on fatty meal is affected by sea buckthorn (Hippophaë rhamnoides) supplementation: NMR metabolomics study”, Food Research International, 58, 23-34, 2014. doi:10.1016/j.foodres.2013.12.010*
  11. Pinto J, Domingues MRM, Galhano E, Pita C, Almeida MC, Carreira IM, Gil AM, “Human plasma stability during handling and storage: impact on NMR metabolomics”, Analyst,139 (5), 1168 – 1177, 2014. doi: 10.1039/c3an02188b. 
  12. Pereira SI, Figueiredo PI, Barros AS, Dias MC, Santos C, Duarte IF, Gil AM, “Changes in the metabolome of lettuce leaves due to exposure to mancozeb pesticide”, Food Chemistry, 154, 291-298, 2014. doi: 10.1016/j.foodchem.2014.01.019
  13. Carregosa V, Figueira E, Gil AM, Pereira S, Pinto J, Soares AMVM, Freitas R, “Tolerance of Venerupis philippinarumto salinity: osmotic and metabolic aspects.”, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 171, 36-43. 1531-4332, 2014. doi:10.1016/j.cbpa.2014.02.009*
  14. Lima MRM, Diaz S, Lamego, I, Grusak MA, Vasconcelos MW, Gil AM,  “Nuclear Magnetic Resonance (NMR) Metabolomics of Iron Deficiency in Soybean Leaves”, Journal of Proteome Research, 13(6),3075-3087, 2014. doi: 10.1021/pr500279f
  15. Pinto J, Maciel E, Melo T, Domingues MRM, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Maternal plasma phospholipids are altered in trisomy 21cases and prior to preeclampsia and preterm outcomes”, Rapid Communications in Mass Spectrometry, 28(14), 1635-1638, 2014.
  16. Lamego I, Duarte I, Marques MPM, Gil AM, “Metabolic markers of osteosarcoma response to doxorubicinand methotrexate treatment: comparison to cisplatin”, Journal of Proteome Research, 13, 6033−6045,2014.doi:10.1021/pr500907d
  17. Rocha CM, Barros AS, Goodfellow BJ, Carreira IM, Gomes A, Sousa A, Bernardo J, Carvalho L, Gil AM, Duarte IF, “NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma”, Carcinogenesis, 36 (1), 68-75, 2015. doi: 10.1093/carcin/bgu226 *
  18. Pinto J, Barros A, Domingues MR, Goodfellow BJ, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine”, Journal of Proteome Research, 14, 1263-1274, 2015. doi: 10.1021/pr5011982
  19. Pinto J, Almeida L, Martins A, Duarte D, Barros A, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Prediction of gestational diabetes through NMR metabolomics of maternal blood”, Journal of Proteome Research, 14(6), 2696–2706, 2015. doi: 10.1021/acs.jproteome.5b00260
  20. Pinto J, Almeida L, Martins A, Duarte D, Domingues MR, Barros A, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, ”Impact of fetal chromosomal disorders impact on maternal blood metabolome: towards new biomarkers?”, American Journal of Obstetrics and Gynecology, 213 (6), 1.e1-1.e15, 2015. doi:10.1016/j.ajog.2015.07.032
  21. Gil AM, Guedes P, Monteiro MS, Duarte IF, “NMRmetabolomics of renal cancer: an overview”, Bioanalysis, Special Report, 7(18), 2361–2374, 2015. doi: 10.4155/bio.15.167
  22. Carrola J, Bastos V, Oliveira JMPF, Oliveira H, Santos C, Barros AS, Gil AM, Duarte IF, “Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics”, Archives of Biochemistry and Biophysics, 589, 53-61, 2016. doi: 10.1016/j.abb.2015.08.022*
  23. Diaz SO and Pinto J, Barros AS, Morais E, Duarte D, Negrao F, Pita C, Almeida MC, Carreira IM, Spraul M, Gil AM, “Newborn urinary metabolic signatures of prematurity and other disorders: a case control study”, Journal of Proteome Research, 15(1), 311–325, 2016. doi: 10.1021/acs.jproteome.5b00977
  24. Carrola J, Bastos V, Jarak I, Oliveira-Silva R, Malheiro E, Daniel da Silva AL, Oliveira H, Santos C, Gil AM, Duarte IF, “Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure-activity relationships and role of ionic silver and oxidative stress”, Nanotoxicology, 10(8), 1105-17, 2016.doi: 10.1080/17435390.2016.1177744*
  25. Pinto J, Diaz SO, Aguiar E, Duarte D, Barros AS, Galhano E, Pita C, Almeida MC, Carreira IM, Spraul M, Gil AM, “Metabolic profiling of maternal urine can aid clinical management of Gestational Diabetes Mellitus”, Metabolomics, 2016,12, article no. 105. doi: 10.1007/s11306-016-1046-1
  26. Vasconcelos DM, Gonçalves RM, Almeida CR, Pereira IO, Oliveira MI, Neves N, Silva AM, Ribeiro AC, Cunha C, Almeida AR, Ribeiro CC, Gil AM, Seebach E, Kynast KL, Richter W, Lamghari M, Santos SG, Barbosa AM,“Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration”, Biomaterials, 111, 163-178, 2016. doi: 10.1016/j.biomaterials.2016.10.004. *
  27. Monteiro MS, Barros AS, Pinto J, Carvalho M, Pires-Luís AS, Jerónimo C, Henrique R, Bastos ML, Gil AM and Pinho PG (equal contribution of last 2 authors), “Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma”, Scientific Reports – Nature Publishing Group, 6, Article number: 37275, 2016.
  28. Lamego I, Marques MPM, Duarte IF, Martin AS, Oliveira H, Gil AM, “Impact of the Pd2Spermine chelate on osteosarcoma metabolism: an NMR metabolomics study”, Journal of Proteome Research,16(4), 1773-1783, 2017. http://dx.doi.org/10.1021/acs.jproteome.7b00035
  29. Monteiro M, Moreira N, Pinto J, Pires-Luís AS, Henrique R, Jerónimo C, Bastos ML, Gil AM, Carvalho M, Guedes de Pinho M, “GC-MSmetabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of Renal Cell Carcinomapatients”, Journal of Cellular and Molecular Medicine, 21 (9), 2092-21052017, 2017. doi: 10.1111/jcmm.13132
  30. Lains, I., Duarte, D., Barros, A.S., Martins, A.S., Gil, J., Miller, J.B., Marques, M., Mesquita, T., Kim, I.K., Cachulo, M.L., Vavvas, D., Carreira, I.M., Murta, J.N., Silva, R., Miller, J.W., Husain, D., Gil, A.M., “Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy”, PLOS ONE, 12(5): e0177749, 2017. https://doi.org/10.1371/journal.pone.0177749
  31. Jarak I, Carrola J, Barros AS, Gil AM, Pereira ML, Corvo ML, Duarte IF, “Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model”, Toxicological Sciences, 159(2), 422-435, 2017. doi: 10.1093/toxsci/kfx142 *
  32. Gil AM, Duarte D, “Biofluid metabolomics in preterm birth research”, Reproductive Sciences, 2018, in press. doi: 10.1177/1933719118756748
  33. Gil AM, Duarte D., Pinto J, Barros AS, “Assessing exposome effects on pregnancy through urine metabolomics of a Portuguese (Estarreja) cohort”, Journal of Proteome Research, 17(3), 1278-1289, 2018. doi: 10.1021/acs.jproteome.7b00878
  34. Carrola J, Pinto R, Nasirpour M, Freire C, Gil AM, Santos C, Oliveira H, Duarte I,NMR metabolomics reveals metabolism-mediated protective effects in liver (HepG2) cells exposed to sub-toxic levels of silver nanoparticles", Journal of Proteome Research, 17(4), 1636-1646, 2018, doi: 10.1021/acs.jproteome.7b00905
  35. Gil AM, Fernandes MH, Duarte IF, Metabolomics in Biomaterial Research, in Narayan R (Ed), Encyclopedia of Biomedical Engineering, vol 3, pp. 432-442, Elsevier, 2019, ISBN: 9780128048290, doi: 10.1016/B978-0-12-801238-3.10888-8 
  36. Silva JCP, Mota M, Matins FO, Nogueira C, Gonçalves T, Carneiro T, Pinto J, Duarte D, Barros AS, Jones JG, Gil AM, Intestinal microbial and metabolic profiling of mice fed with high-glucose and high-fructose diets, Journal of Proteome Research, 17(8), 2880-2891, 2018. Doi: 10.1021/acs.jproteome.8b00354

Projectos

Actualização e expansão do laboratório de RMN da Universidade de Aveiro (REEQ/934/QUI/2005)

CoordenadorFundação para a Ciência e a Tecnologia
Este projecto teve como objectivo a actualização e expansão dos 3 espectrómetros de RMN já existentes na Universidade de Aveiro (UA) (de 300 a 500 MHz). Em 2000, a UA apoiou financeiramente uma primeira actualização destes equipamentos não tendo sido nessa altura possível adquirir muitos itens essenciais à utilização máxima dos espectrómetros em...

Análise de perfis metabólicos: uma nova metodologia para avaliação dos efeitos toxicológicos e biológicos de nanomateriais (PTDC/SAU-TOX/120953/2010)

ParticipanteFundação para a Ciência e a Tecnologia
perfil metabólico e metabonómica nanopartículas de prata efeitos toxicológicos e biológicos nanotoxicologia

ASTHMA - Gestão futura da asma apoiada por amostragem não invasiva: contributos para a definição de um meio diagnóstico rápido e não invasivo (PTDC/QUI-QUI/117803/2010)

ParticipanteFundação para a Ciência e a Tecnologia
Asthma Non-invasive sampling Chromatographic and 1H NMR-based methodologies Metabolomic patterns

Bioreactor para Engenharia de Tecido Osseo Conduzido por Metabolomica (BioImplant)

ParticipanteFundação para a Ciência e a Tecnologia

Cellulose: Surface Properties, Interaction with Binding Domains and Enzymatic Modification (POCTI/QUI/44368/2002)

Coordenador LocalFundação para a Ciência e a Tecnologia
surface energy cellulose transesterification CBD

Degenerescência macular relacionada com a idade - o perfil metabolómico permite distinguir os progressores? (HMSP-ICJ/0006/2013)

Coordenador LocalFundação para a Ciência e a Tecnologia
degenerescência macular relacionada com a idade progressão da doença metabolómica espetroscopia por ressonância magnética

Effects of environmental hazards of the Estarreja region on pregnancy metabolism (CERN (France)-OHMI Estarreja (Portugal))

CoordenadorOther International

Estudo metabono?mico do cancro do pulma?o em estado ciru?rgico: pesquisa de assinaturas metabo?licas em tecidos e biofluidos (CIMAGO 04/12)

ParticipanteOther National

Estudo Metabonómico de desordens da grávida e do feto por espectroscopia de ressonância magnética nuclear (RMN): Caracterização bioquímica e métodos de diagnóstico (PTDC/QUI/66523/2006)

CoordenadorFundação para a Ciência e a Tecnologia
biofluidos metabonómica espectroscopia de RMN gravidez

Impacto Bioquímico de Agentes Anticancerígenos de Platina e Paládio (BIOIMPACT)

Coordenador LocalFundação para a Ciência e a Tecnologia
anticancer Pt(II) and Pd(II) agents;spectral cyto- and histopathology;metabolomics;cellular biodistribution

Nanoquímica de compósitos magnéticos/luminiscentes para aplicações de diagnóstico médico in vitro (PTDC/QUI/67712/2006)

ParticipanteFundação para a Ciência e a Tecnologia
Nanopartículas Nanocompósitos Magnetismo/Luminescência Bioconjugação de anticorpos

O papel do intestino no desenvolvimento da esteatose hepatica induzida pela frutose (PTDC/SAU-MET/111398/2009)

Coordenador LocalFundação para a Ciência e a Tecnologia
ApoB48 steatosis endotoxin lipogenesis

Regulação do proteoma de fungos pela disponibilidade de substrato: enzimas despolimerizantes capazes de alterar a nanoestrutura de biopolímeros (POCI/QUI/56229/2004)

Coordenador LocalFundação para a Ciência e a Tecnologia
Proteoma fúngico nanoestrutura de bio-polímeros enzymas despolimerizantes cortiça

Suportes implantáveis para Quimioterapia localizada do Osteossarcoma (PTDC/SAU-BEB/66896/2006)

ParticipanteFundação para a Ciência e a Tecnologia
Osteo-sarcoma Suportes terapêuticos implantáveis Matrizes silicato-ciclodextrina Cápsulas moleculares

Publicações

A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy

Musio, B; Ragone, R; Todisco, S; Rizzuti, A; Latronico, M; Mastrorilli, P; Pontrelli, S; Intini, N; Scapicchio, P; Triggiani, M; Di Noia, T; Acquotti, D; Airoldi, C; Assfalg, M; Barge, A; Bateman, L; Benevelli, F; Bertelli, D; Bertocchi, F; Bieliauskas, A; Borioni, A; Caligiani, A; Callone, E; Camra, A; Marincola, FC; Chalasani, D; Consonni, R; Dambruoso, P; Davalli, S; David, T; Diehl, B; Donarski, J; Gil, AM; Gobetto, R; Goldoni, L; Hamon, E; Harwood, JS; Kobrlova, A; Longobardi, F; Luisi, R; Mallamace, D; Mammi, S; Martin-Biran, M; Mazzei, P; Meie, A; Milone, S; Vilchez, DM; Mulder, RJ; Napoli, C; Ragno, D; Randazzo, A; Rossi, MC; Rotondo, A; Sackus, A; Barajas, ES; Schievano, E; Sitaram, B; Stevanato, L; Takis, PG; Teipel, J; Thomas, F; Torregiani, E; Valensin, D; Veronesi, M; Warren, J; Wist, J; Zailer-Hafer, E; Zuccaccia, C; Gallo, V
2020, TALANTA, 214.
ISBN: 1873-3573

Cytotoxicity of Platinum and Palladium Chelates against Osteosarcoma

Martins, AS; de Carvalho, ALMB; Lamego, I; Marques, PM; Gil, AM
2020, CHEMISTRYSELECT, 5, 20, 5993-6000.

Macrophage Metabolomics Reveals Differential Metabolic Responses to Subtoxic Levels of Silver Nanoparticles and Ionic Silver

Carrola, J; Bastos, V; Daniel-da-Silva, AL; Gil, AM; Santos, C; Oliveira, H; Duarte, IF
2020, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2020, 19, 1867-1876.
ISBN: 1099-0682

Metabolomic studies of breast cancer in murine models: A review

Araujo, R; Bispo, D; Helguero, LA; Gil, AM
2020, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866, 5.
ISBN: 1879-260X

Metabolic Aspects of Palladium(II) Potential Anti-Cancer Drugs

Carneiro, TJ; Martins, AS; Marques, MPM; Gil, AM
2020, FRONTIERS IN ONCOLOGY, 10.

Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures

Bispo, D; Fabris, V; Lamb, CA; Lanari, C; Helguero, LA; Gil, AM
2020, BIOMOLECULES, 10, 9.
ISBN: 2218-273X

Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration

Lains, I; Duarte, D; Barros, AS; Martins, AS; Carneiro, TJ; Gil, JQ; Miller, JB; Marques, M; Mesquita, TS; Barreto, P; Kim, IK; Cachulo, MD; Vavvas, DG; Carreira, IM; Murta, JN; Silva, R; Miller, JW; Husain, D; Gil, AM
2019, JOURNAL OF PROTEOME RESEARCH, 18, 3, 1278-1288.
ISBN: 1535-3907

NMR metabolomics to study the metabolic response of human osteoblasts to non-poled and poled poly (L-lactic) acid

Ara?jo, R; Carneiro, TJ; Marinho, P; da Costa, MM; Roque, A; Silva, OABDE; Fernandes, MH; Vilarinho, PM; Gil, AM
2019, MAGNETIC RESONANCE IN CHEMISTRY, 57, 11, 919-933.
ISBN: 1097-458X

Saliva NMR metabolomics: Analytical issues in pediatric oral health research

Pereira, JL; Duarte, D; Carneiro, TJ; Ferreira, S; Cunha, B; Soares, D; Costa, AL; Gil, AM
2019, ORAL DISEASES, 25, 6, 1545-1554.
ISBN: 1601-0825

Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice

Carneiro, TJ; Araujo, R; Vojtek, M; Goncalves-Monteiro, S; Diniz, C; de Carvalho, ALMB; Marques, MPM; Gil, AM
2019, METABOLITES, 9, 11.
ISBN: 2218-1989

NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles

Carrola, J; Pinto, RJB; Nasirpour, M; Freire, CSR; Gil, AM; Santos, C; Oliveira, H; Duarte, IF
2018, JOURNAL OF PROTEOME RESEARCH, 17, 4, 1636-1646.

Assessing Exposome Effects on Pregnancy through Urine Metabolomics of a Portuguese (Estarreja) Cohort

Gil, AM; Duarte, D; Pinto, J; Barros, AS
2018, JOURNAL OF PROTEOME RESEARCH, 17, 3, 1278-1289.

Biofluid Metabolomics in Preterm Birth Research

Gil, AM; Duarte, D
2018, REPRODUCTIVE SCIENCES, 25, 7, 967-977.

Intestinal Microbial and Metabolic Profiling of Mice Fed with High Glucose and High-Fructose Diets

Silva, JCP; Mota, M; Martins, FO; Nogueira, C; Goncalves, T; Carneiro, T; Pinto, J; Duarte, D; Barros, AS; Jones, JG; Gil, AM
2018, JOURNAL OF PROTEOME RESEARCH, 17, 8, 2880-2891.

GC-MS metabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of renal cell carcinoma patients

Monteiro, M; Moreira, N; Pinto, J; Pires-Luis, AS; Henrique, R; Jeronimo, C; Bastos, MD; Gil, AM; Carvalho, M; de Pinho, PG
2017, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21, 9, 2092-2105.

Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy

Lains, I; Duarte, D; Barros, AS; Martins, AS; Gil, J; Miller, JB; Marques, M; Mesquita, TAN; Kim, IK; Cachulo, MD; Vavvas, D; Carreira, IM; Murta, JN; Silva, R; Miller, JW; Husain, D; Gil, AM
2017, PLOS ONE, 12, 5.

Impact of the Pd(2)Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

Lamego, I; Marques, MPM; Duarte, IF; Martins, AS; Oliveira, H; Gil, AM
2017, JOURNAL OF PROTEOME RESEARCH, 16, 4, 1773-1783.
ISBN: 1535-3907

From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model

Jarak, I; Carrola, J; Barros, AS; Gil, AM; Pereira, MD; Corvo, ML; Duarte, IF
2017, TOXICOLOGICAL SCIENCES, 159, 2, 422-435.
ISBN: 1096-0929

Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics

Carrola, J; Bastos, V; de Oliveira, JMPF; Oliveira, H; Santos, C; Gil, AM; Duarte, IF
2016, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 589, 53-61.

Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration

Vasconcelos, DM; Goncalves, RM; Almeida, CR; Pereira, IO; Oliveira, MI; Neves, N; Silva, AM; Ribeiro, AC; Cunha, C; Almeida, AR; Ribeiro, CC; Gil, AM; Seebach, E; Kynast, KL; Richter, W; Lamghari, M; Santos, SG; Barbosa, MA
2016, BIOMATERIALS, 111, 163-178.

Metabolic profiling of maternal urine can aid clinical management of gestational diabetes mellitus

Pinto, J; Diaz, SO; Aguiar, E; Duarte, D; Barros, AS; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Spraul, M; Gil, AM
2016, METABOLOMICS, 12, 6.

Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure-activity relationships and role of ionic silver and oxidative stress

Carrola, J; Bastos, V; Jarak, I; Oliveira-Silva, R; Malheiro, E; Daniel-da-Silva, AL; Oliveira, H; Santos, C; Gil, AM; Duarte, IF
2016, NANOTOXICOLOGY, 10, 8, 1105-1117.

Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study

Diaz, SO; Pinto, J; Barros, AS; Morais, E; Duarte, D; Negrao, F; Pita, C; Almeida, MD; Carreira, IM; Spraul, M; Gil, AM
2016, JOURNAL OF PROTEOME RESEARCH, 15, 1, 311-325.

Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma

Monteiro, MS; Barros, AS; Pinto, J; Carvalho, M; Pires-Luis, AS; Henrique, R; Jeronimo, C; Bastos, MDL; Gil, AM; de Pinho, PG
2016, SCIENTIFIC REPORTS, 6.

Impact of fetal chromosomal disorders on maternal blood metabolome: toward new biomarkers?

Pinto, J; Almeida, LM; Martins, AS; Duarte, D; Domingues, MRM; Barros, AS; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2015, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 213, 6.

NMR metabolomics of renal cancer: an overview

Gil, AM; de Pinho, PG; Monteiro, MS; Duarte, IF
2015, BIOANALYSIS, 7, 18, 2361-2374.

Exploratory urinary metabolomic profiling of renal cell carcinoma using H-1 NMR spectroscopy and multivariate analysis

Monteiro, M; Barros, A; Carvalho, M; Pires-Luis, AS; Jeronimo, C; Henrique, R; de Lourdes, BM; Gil, A; de Pinho, PG
2015, TOXICOLOGY LETTERS, 238, 2, S233-S234.

Following Healthy Pregnancy by NMR Metabolomics of Plasma and Correlation to Urine

Pinto, J; Barros, AS; Domingues, MRM; Goodfellow, BJ; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2015, JOURNAL OF PROTEOME RESEARCH, 14, 2, 1263-1274.

Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood

Pinto, J; Almeida, LM; Martins, AS; Duarte, D; Barros, AS; Gahano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2015, JOURNAL OF PROTEOME RESEARCH, 14, 6, 2696-2706.

NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma

Rocha, CM; Barros, AS; Goodfellow, BJ; Carreira, IM; Gomes, A; Sousa, V; Bernardo, J; Carvalho, L; Gil, AM; Duarte, IF
2015, CARCINOGENESIS, 36, 1, 68-75.

Tolerance of Venerupis philippinarum to salinity: Osmotic and metabolic aspects

Carregosa, V; Figueira, E; Gil, AM; Pereira, S; Pinto, J; Soares, AMVM; Freitas, R
2014, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 171, 36-43.

Different responses of young and expanded lettuce leaves to fungicide Mancozeb: chlorophyll fluorescence, lipid peroxidation, pigments and proline content

Dias, MC; Figueiredo, P; Duarte, IF; Gil, AM; Santos, C
2014, PHOTOSYNTHETICA, 52, 1, 148-151.

NMR metabolomics of human blood and urine in disease research

Duarte, IF; Diaz, SO; Gil, AM
2014, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 93, 17-26.

Metabolic Markers of MG-63 Osteosarcoma Cell Line Response to Doxorubicin and Methotrexate Treatment: Comparison to Cisplatin

Lamego, I; Duarte, IF; Marques, MPM; Gil, AM
2014, JOURNAL OF PROTEOME RESEARCH, 13, 12, 6033-6045.

Nuclear Magnetic Resonance Metabolomics of Iron Deficiency in Soybean Leaves

Lima, MRM; Diaz, SO; Lamego, I; Grusak, MA; Vasconcelos, MW; Gil, AM
2014, JOURNAL OF PROTEOME RESEARCH, 13, 6, 3075-3087.

Postprandial response on fatty meal is affected by sea buckthorn (Hippophae rhamnoides) supplementation: NMR metabolomics study

Lindstedt, A; Jarvinen, R; Sinkkonen, J; Lehtonen, HM; Graca, G; Viitanen, M; Gil, AM; Kallio, H
2014, FOOD RESEARCH INTERNATIONAL, 58, 23-34.

Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

Loureiro, CC; Duarte, IF; Gomes, J; Carrola, J; Barros, AS; Gil, AM; Bousquet, J; Bom, AT; Rocha, SM
2014, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133, 1, 261-263.

Changes in the metabolome of lettuce leaves due to exposure to mancozeb pesticide

Pereira, SI; Figueiredo, PI; Barros, AS; Dias, MC; Santos, C; Duarte, IF; Gil, AM
2014, FOOD CHEMISTRY, 154, 291-298.

Human plasma stability during handling and storage: impact on NMR metabolomics

Pinto, J; Domingues, MRM; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2014, ANALYST, 139, 5, 1168-1177.

Maternal plasma phospholipids are altered in trisomy 21 cases and prior to preeclampsia and preterm outcomes

Pinto, J; Maciel, E; Melo, TS; Domingues, MRM; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2014, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 28, 14, 1635-1638.

H-1 NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal

Lehtonen, HM; Lindstedt, A; Jarvinen, R; Sinkkonen, J; Graca, G; Viitanen, M; Kallio, H; Gil, AM
2013, FOOD CHEMISTRY, 138, 2-3, 982-990.

Second Trimester Maternal Urine for the Diagnosis of Trisomy 21 and Prediction of Poor Pregnancy Outcomes

Diaz, SO; Barros, AS; Goodfellow, BJ; Duarte, IF; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2013, JOURNAL OF PROTEOME RESEARCH, 12, 6, 2946-2957.

Mid-infrared (MIR) metabolic fingerprinting of amniotic fluid: A possible avenue for early diagnosis of prenatal disorders?

Graca, G; Moreira, AS; Correia, AJV; Goodfellow, BJ; Barros, AS; Duarte, IF; Carreira, IM; Galhano, E; Pita, C; Almeida, MD; Gil, AM
2013, ANALYTICA CHIMICA ACTA, 764, 24-31.

Following Healthy Pregnancy by Nuclear Magnetic Resonance (NMR) Metabolic Profiling of Human Urine

Diaz, SO; Barros, AS; Goodfellow, BJ; Duarte, IF; Carreira, IM; Galhano, E; Pita, C; Almeida, MD; Gil, AM
2013, JOURNAL OF PROTEOME RESEARCH, 12, 2, 969-979.

Potential Markers of Cisplatin Treatment Response Unveiled by NMR Metabolomics of Human Lung Cells

Duarte, IF; Ladeirinha, AF; Lamego, I; Gil, AM; Carvalho, L; Carreira, IM; Melo, JB
2013, MOLECULAR PHARMACEUTICS, 10, 11, 4242-4251.

Metabolic response of human keratinocytes to silver nanoparticles: A metabolomics study

Carrola, J; Gil, AM; Silva, ALD; Bastos, V; Oliveira, H; Oliveira, JMPF; Santos, C; Duarte, IF
2013, TOXICOLOGY LETTERS, 221, S242-S243.

Metabolic profiling of biofluids: potential in lung cancer screening and diagnosis

Duarte, IF; Rocha, CM; Gil, AM
2013, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 13, 7, 737-748.

Impact of magnetic nanofillers in the swelling and release properties of kappa-carrageenan hydrogel nanocomposites

Daniel-da-Silva, AL; Moreira, J; Neto, R; Estrada, AC; Gil, AM; Trindade, T
2012, CARBOHYDRATE POLYMERS, 87, 1, 328-335.

Metabolic signatures of cancer unveiled by NMR spectroscopy of human biofluids

Duarte, IF; Gil, AM
2012, PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 62, 51-74.

UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers

Graca, G; Goodfellow, BJ; Barros, AS; Diaz, S; Duarte, IF; Spagou, K; Veselkov, K; Want, EJ; Lindon, JC; Carreira, IM; Galhano, E; Pita, C; Gil, AM
2012, MOLECULAR BIOSYSTEMS, 8, 4, 1243-1254.

Can Biofluids Metabolic Profiling Help to Improve Healthcare during Pregnancy?

Graca, G; Diaz, SO; Pinto, J; Barros, AS; Duarte, IF; Goodfellow, BJ; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2012, SPECTROSCOPY-AN INTERNATIONAL JOURNAL, 27, 5-6, 515-523.

Monitoring pregnancy and prenatal disorders through NMR metabolic profiling of maternal blood plasma

Pinto, J; Barros, AS; Duarte, IF; Goodfellow, BJ; Galhano, E; Pita, C; Carreira, IM; Almeida, MD; Gil, AM
2012, FEBS JOURNAL, 279, 406-406.

Swelling and Release Properties of Functional kappa-carrageenan Hydrogel Nanocomposites

da Silva, ALD; Salgueiro, AM; Fateixa, S; Moreira, J; Estrada, AC; Gil, AM; Trindade, T
2012, MULTIFUNCTIONAL POLYMER-BASED MATERIALS, 1403, 213-219.
ISBN: 978-1-60511-380-7

Lung cancer metabolic signatures unveiled by metabonomics

Rocha, CM; Carrola, J; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, S48-S48.

NMR methods for beer characterization and quality control

Rodrigues, JE; Gil, AM
2011, MAGNETIC RESONANCE IN CHEMISTRY, 49, S37-S45.

Probing beer aging chemistry by nuclear magnetic resonance and multivariate analysis

Rodrigues, JA; Barros, AS; Carvalho, B; Brandao, T; Gil, AM
2011, ANALYTICA CHIMICA ACTA, 702, 2, 178-187.

Evaluation of beer deterioration by gas chromatography-mass spectrometry/multivariate analysis: A rapid tool for assessing beer composition

Rodrigues, JA; Barros, AS; Carvalho, B; Brandao, T; Gil, AM; Ferreira, ACS
2011, JOURNAL OF CHROMATOGRAPHY A, 1218, 7, 990-996.

Synthesis and swelling behavior of temperature responsive kappa-carrageenan nanogels

Daniel-da-Silva, AL; Ferreira, L; Gil, AM; Trindade, T
2011, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 355, 2, 512-517.

Solid state C-13 CP-MAS NMR and FT-IR spectroscopic analysis of cuticular fractions of berries and suberized membranes of potato

Jarvinen, R; Silvestre, AJD; Gil, AM; Kallio, H
2011, JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 24, 3, 334-345.

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine

Carrola, J; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, JOURNAL OF PROTEOME RESEARCH, 10, 1, 221-230.

Metabolic Biomarkers of Prenatal Disorders: An Exploratory NMR Metabonomics Study of Second Trimester Maternal Urine and Blood Plasma

Diaz, SO; Pinto, J; Graca, G; Duarte, IF; Barros, AS; Galhano, E; Pita, C; Almeida, MD; Goodfellow, BJ; Carreira, IM; Gil, AM
2011, JOURNAL OF PROTEOME RESEARCH, 10, 8, 3732-3742.

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma

Rocha, CM; Carrola, J; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, JOURNAL OF PROTEOME RESEARCH, 10, 9, 4314-4324.

Lung tumors' biomarker profiles of malignancy and histological type assessed by nuclear magnetic resonance (NMR) spectroscopy

Carvalho, LM; Duarte, IF; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Gomes, AI; Oliveira, DM; Sousa, VM; Bernardo, J
2010, HISTOPATHOLOGY, 57, 226-226.

Effect of novel cutinase CcCut1 in degrading potato suberin and berry cutin

Jarvinen, R; Holopainen, U; Nyyssola, A; Silvestre, A; Gil, AM; Lehtinen, P; Buchert, J; Kallio, H
2010, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 240.

Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours?

Duarte, IF; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L
2010, VIRCHOWS ARCHIV, 457, 6, 715-725.

Application of Fourier transform infrared spectroscopy and orthogonal projections to latent structures/partial least squares regression for estimation of procyanidins average degree of polymerisation

Passos, CP; Cardoso, SM; Barros, AS; Silva, CM; Coimbra, MA
2010, ANALYTICA CHIMICA ACTA, 661, 2, 143-149.

Quantification of organic acids in beer by nuclear magnetic resonance (NMR)-based methods

Rodrigues, JEA; Erny, GL; Barros, AS; Esteves, VI; Brandao, T; Ferreira, AA; Cabrita, E; Gil, AM
2010, ANALYTICA CHIMICA ACTA, 674, 2, 166-175.

Nuclear Magnetic Resonance (NMR) Study of the Effect of Cisplatin on the Metabolic Profile of MG-63 Osteosarcoma Cells

Duarte, IF; Lamego, I; Marques, J; Marques, MPM; Blaise, BJ; Gil, AM
2010, JOURNAL OF PROTEOME RESEARCH, 9, 11, 5877-5886.

Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study

Graca, G; Duarte, IF; Barros, AS; Goodfellow, BJ; Diaz, SO; Pinto, J; Carreira, IM; Galhano, E; Pita, C; Gil, AM
2010, JOURNAL OF PROTEOME RESEARCH, 9, 11, 6016-6024.

Metabolic Profiling of Human Lung Cancer Tissue by H-1 High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy

Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Humpfer, E; Spraul, M; Carreira, IM; Melo, JB; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2010, JOURNAL OF PROTEOME RESEARCH, 9, 1, 319-332.

Complete H-1 resonance assignment of beta-maltose from H-1-H-1 DQ-SQ CRAMPS and H-1 (DQ-DUMBO)-C-13 SQ refocused INEPT 2D solid-state NMR spectra and first principles GIPAW calculations

Webber, AL; Elena, B; Griffin, JM; Yates, JR; Pham, TN; Mauri, F; Pickard, CJ; Gil, AM; Stein, R; Lesage, A; Emsley, L; Brown, SP
2010, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12, 26, 6970-6983.

NMR metabolomics of esca disease-affected Vitis vinifera cv. Alvarinho leaves

Lima, MRM; Felgueiras, ML; Graca, G; Rodrigues, JEA; Barros, A; Gil, AM; Dias, ACP
2010, JOURNAL OF EXPERIMENTAL BOTANY, 61, 14, 4033-4042.

Analytical Approaches toward Successful Human Cell Metabolome Studies by NMR Spectroscopy

Duarte, IF; Marques, J; Ladeirinha, AF; Rocha, C; Lamego, I; Calheiros, R; Silva, TM; Marques, MPM; Melo, JB; Carreira, IM; Gil, AM
2009, ANALYTICAL CHEMISTRY, 81, 12, 5023-5032.

Suberin of Potato (Solanum tuberosum Var. Nikola): Comparison of the Effect of Cutinase CcCut1 with Chemical Depolymerization

Jarvinen, R; Silvestre, AJD; Holopainen, U; Kaimainen, M; Nyyssola, A; Gil, AM; Neto, CP; Lehtinen, P; Buchert, J; Kallio, H
2009, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, 19, 9016-9027.

Specific Solvation Interactions of CO2 on Acetate and Trifluoroacetate Imidazolium Based Ionic Liquids at High Pressures

Carvalho, PJ; Alvarez, VH; Schroder, B; Gil, AM; Marrucho, IM; Aznar, M; Santos, LMNBF; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 19, 6803-6812.

H-1 NMR Based Metabonomics of Human Amniotic Fluid for the Metabolic Characterization of Fetus Malformations

Graca, G; Duarte, IF; Barros, AS; Goodfellow, BJ; Diaz, S; Carreira, IM; Couceiro, AB; Galhano, E; Gil, AM
2009, JOURNAL OF PROTEOME RESEARCH, 8, 8, 4144-4150.

Identification of metabolites in human hepatic bile using 800 MHz H-1 NMR spectroscopy, HPLC-NMR/MS and UPLC-MS

Duarte, IF; Legido-Quigley, C; Parker, DA; Swann, JR; Spraul, M; Braumann, U; Gil, AM; Holmes, E; Nicholson, JK; Murphy, GM; Vilca-Melendez, H; Heatond, N; Lindon, JC
2009, MOLECULAR BIOSYSTEMS, 5, 2, 180-190.

Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan

Daniel-da-Silva, AL; Fateixa, S; Guiomar, AJ; Costa, BFO; Silva, NJO; Trindade, T; Goodfellow, BJ; Gil, AM
2009, NANOTECHNOLOGY, 20, 35.

Analysis of Non-Aromatic Organic Acids in Beer by CE and Direct Detection Mode with Diode Array Detection

Erny, GL; Rodrigues, JEA; Gil, AM; Barros, AS; Esteves, VI
2009, CHROMATOGRAPHIA, 70, 11-12, 1737-1742.

NMR metabonomics for mammalian cell metabolism studies

Duarte, IF; Lamego, I; Rocha, C; Gil, AM
2009, BIOANALYSIS, 1, 9, 1597-1614.

Magnetic carrageenan nanospheres for medical imaging

Daniel-da-Silva, AL; Trindade, T; Goodfellow, BJ; Gil, AM
2008, TISSUE ENGINEERING PART A, 14, 5, 875-875.

Characterization of dextrin hydrogels by FTIR spectroscopy and solid state NMR spectroscopy

Garcia, H; Barros, AS; Goncalves, C; Gama, FM; Gil, AM
2008, EUROPEAN POLYMER JOURNAL, 44, 7, 2318-2329.

Rheological behavior of thermoreversible kappa-carrageenan/nanosilica gels

Daniel-Da-Silva, AL; Pinto, F; Lopes-Da-Silva, JA; Trindade, T; Goodfellow, BJ; Gil, AM
2008, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 320, 2, 575-581.

Effects of magnetite nanoparticles on the thermorheological properties of carrageenan hydrogels

Daniel-Da-Silva, AL; Loio, R; Lopes-Da-Silva, JA; Trindade, T; Goodfellow, BJ; Gil, AM
2008, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 324, 1-2, 205-211.

Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy

Graca, G; Duarte, IF; Goodfellow, BJ; Carreira, IM; Couceiro, AB; Domingues, MD; Spraul, M; Tseng, LH; Gil, AM
2008, ANALYTICAL CHEMISTRY, 80, 15, 6085-6092.

Production of Bioactive Nano-Hydroxyapatite/Polysaccharide Composites for Bone Tissue Engineering

Daniel-da-Silva, AL; Gil, AM; Correia, RN
2008, ADVANCED MATERIALS FORUM IV, 587-588, 22-+.

Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution H-1 NMR spectroscopy

Duarte, IF; Goodfellow, BJ; Barros, A; Jones, JG; Barosa, C; Diogo, L; Garcia, P; Gill, AM
2007, NMR IN BIOMEDICINE, 20, 4, 401-412.

Synthesis and characterization of porous kappa-carrageenan/calcium phosphate nanocomposite scaffolds

Daniel-da-Silva, AL; Lopes, AB; Gil, AM; Correia, RN
2007, JOURNAL OF MATERIALS SCIENCE, 42, 20, 8581-8591.

Metabolic profiling of liver from hypercholesterolemic pigs fed rye or wheat fiber and from normal pigs. High-resolution magic angle spinning H-1 NMR spectroscopic study

Bertram, HC; Duarte, IF; Gil, AM; Knudsen, KEB; Laerke, HN
2007, ANALYTICAL CHEMISTRY, 79, 1, 168-175.

Potential of NMR Spectroscopy for the study of human amniotic fluid

Graca, G; Duarte, IF; Goodfellow, BJ; Barros, AS; Carreira, IM; Couceiro, AB; Spraul, M; Gil, AM
2007, ANALYTICAL CHEMISTRY, 79, 21, 8367-8375.

In situ synthesis of magnetite nanoparticles in carrageenan gels

Daniel-da-Silva, AL; Trindade, T; Goodfellow, BJ; Costa, BFO; Correia, RN; Gil, AM
2007, BIOMACROMOLECULES, 8, 8, 2350-2357.

Rheological and nuclear magnetic resonance (NMR) study of the hydration and heating of undeveloped wheat doughs

Lopes-Da-Silva, JA; Santos, DMJ; Freitas, A; Brites, C; Gil, AM
2007, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 55, 14, 5636-5644.

Production and characterization of a new dextrin based hydrogel

Carvalho, J; Goncalves, C; Gil, AM; Gama, FM
2007, EUROPEAN POLYMER JOURNAL, 43, 7, 3050-3059.

Study of natural mango juice spoilage and microbial contamination with Penicillium expansum by high resolution H-1 NMR spectroscopy

Duarte, IF; Delgadillo, I; Gil, AM
2006, FOOD CHEMISTRY, 96, 2, 313-324.

Composition of beer by H-1 NMR spectroscopy: Effects of brewing site and date of production

Almeida, C; Duarte, IF; Barros, A; Rodrigues, J; Spraul, M; Gil, AM
2006, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54, 3, 700-706.

Polymer conformation structure of wheat proteins and gluten subfractions revealed by ATR-FTIR

Li, W; Dobraszczky, BJ; Dias, A; Gil, AM
2006, CEREAL CHEMISTRY, 83, 4, 407-410.

A solid state NMR study of locust bean gum galactomannan and Konjac glucomannan gels

Vieira, MC; Gil, AM
2005, CARBOHYDRATE POLYMERS, 60, 4, 439-448.

Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning H-1 NMR spectroscopy

Duarte, IF; Stanley, EG; Holmes, E; Lindon, JC; Gil, AM; Tang, HR; Ferdinand, R; McKee, CG; Nicholson, JK; Vilca-Melendez, H; Heaton, N; Murphy, GM
2005, ANALYTICAL CHEMISTRY, 77, 17, 5570-5578.

An investigation of weak CH center dot center dot center dot O hydrogen bonds in maltose anomers by a combination of calculation and experimental solid-state NMR spectroscopy

Yates, JR; Pham, TN; Pickard, CJ; Mauri, F; Amado, AM; Gil, AM; Brown, SP
2005, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127, 29, 10216-10220.

Characterization of mango juice by high-resolution NMR, hyphenated NMR, and diffusion-ordered spectroscopy

Duarte, IF; Goodfellow, BJ; Gil, AM; Delgadillo, I
2005, SPECTROSCOPY LETTERS, 38, 3, 319-342.

Application of NMR and hyphenated NMR spectroscopy for the study of beer components

Duarte, IF; Spraul, M; Godejohann, M; Braumann, U; Gil, AM
2003, MAGNETIC RESONANCE IN FOOD SCIENCE: LATEST DEVELOPMENTS, 286, 151-157.
ISBN: 0-85404-886-3

Enzymatic isolation and structural characterisation of polymeric suberin of cork from Quercus suber L.

Rocha, SM; Goodfellow, BJ; Delgadillo, I; Neto, CP; Gil, AM
2001, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 28, 2, 107-119.

Variability of cork from Portuguese Quercus suber studied by solid-state C-13-NMR and FTIR spectroscopies

Lopes, MH; Barros, AS; Neto, CP; Rutledge, D; Delgadillo, I; Gil, AM
2001, BIOPOLYMERS, 62, 5, 268-277.

Spectral editing of C-13 CP/MAS NMR spectra of complex systems: application to the structural characterisation of cork cell walls

Lopes, MH; Sarychev, A; Neto, CP; Gil, AM
2000, SOLID STATE NUCLEAR MAGNETIC RESONANCE, 16, 3, 109-121.

An NMR microscopy study of water absorption in cork

Gil, AM; Lopes, MH; Neto, CP; Callaghan, PT
2000, JOURNAL OF MATERIALS SCIENCE, 35, 8, 1891-1900.

Composition of suberin extracted upon gradual alkaline methanolysis of Quercus suber L. cork

Lopes, MH; Gil, AM; Silvestre, AJD; Neto, CP
2000, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 48, 2, 383-391.

Quantitation of aliphatic suberin in Quercus suber L. cork by FTIR spectroscopy and solid-state C-13-NMR spectroscopy

Lopes, MH; Neto, CP; Barros, AS; Rutledge, D; Delgadillo, I; Gil, AM
2000, BIOPOLYMERS, 57, 6, 344-351.

Very high-resolution H-1 MAS NMR of a natural polymeric material

Gil, AM; Lopes, MH; Neto, CP; Rocha, J
1999, SOLID STATE NUCLEAR MAGNETIC RESONANCE, 15, 1, 59-67.

The structure of cork cell walls viewed by solid state NMR spectroscopy

Gil, AM; Lopes, MH; Neto, CP
1999, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 217, U263-U263.

Solid-state NMR studies of wood and other lignocellulosic materials

Gil, AM; Neto, CP
1999, ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 37, 37, 75-117.
ISBN: 0-12-505337-1

Solid state NMR and FTIR structural studies of cork cell walls: An overview

Lopes, MH; Neto, CP; Gil, AM
1998, ADVANCES IN LIGNOCELLULOSICS CHEMISTRY FOR ECOLOGICALLY FRIENDLY PULPING AND BLEACHING TECHNOLOGIES, 357-360.
ISBN: 972-8021-66-6

A C-13 solid state nuclear magnetic resonance spectroscopic study of cork cell wall structure: The effect of suberin removal

Gil, AM; Lopes, M; Rocha, J; Neto, CP
1997, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 20, 4, 293-305.

Urine metabolomics and proteomics in prenatal health

In Moshe Hod, Vincenzo Berghella, Mary D'Alton, Gian Carlo Di Renzo, Eduard Gratacos, Vassilios Fanos (Eds.), New Technologies and Perinatal Medicine: Prediction and Prevention of Pregnancy Complications
Duarte, D; Almeida, M.C.; Domingues, P.; Gil, A.M.
2019, CRC Press.
ISBN: 978-113-87-06149

Metabolomics in Biomaterial Research

In Roger Narayan (Eds.), Encyclopedia of Biomedical Engineering
Gil AM, Fernandes MH, Duarte IF
2018, 432-442, Elsevier.
ISBN: 978-0-12-805144-3

Metabolómica e complexos metálicos: aliados no combate ao cancro

In Manuel A. Coimbra (Eds.), Bioquímica e Bem-Estar
Martins AS, Marques MPM, Gil AM.
2017, 77-88, Lisboa, Edições Afrontamento.
ISBN: 978-972-36-1560-9

Blood metabolomics in human prenatal and newborn health studies

Global Metabolic Profiling: Clinical Applications
Pinto J, Domingues MR, Gil AM
2014, London, Future Science Ltd.
ISBN: 978-1-909453-62-3

Evaluation of beer deterioration by gas chromatography-mass spectrometry/ multivariate analyis: a rapid tool for assessing beer composition

Flavour Science: Proceedings from XIII Weurman Flavour Research Symposium
Rodrigues, J.A, Barros, A.S., Carvalho, B., Brandão, T., Gil AM, Silva Ferreira, A.C.
2014, San Diego, Elsevier.
ISBN: 978-0-12-398549-1

Nuclear Magnetic Resonance Methods for Metabolomic Investigation of Amniotic Fluid

Methodologies for Metabolomics: Experimental Strategies and Techniques
Gil AM, Graça G
2013, Cambridge, Cambridge University Press.
ISBN: 9,78052E+12

Techniques for analyzing wheat protein

In Stanley P. Cauvain, BakeTran, UK (Eds.), Breadmaking: Improving quality
Gil, AM
2012, Cambridge, Woodhead Publishing Limited.
ISBN: 0 85709 060 7

Metabonomics in Food Science

Encyclopedia of Spectroscopy and Spectrometry
Gil AM
2010, 1513-1520, Oxford, Elsevier.
ISBN: 978-0122266805

Methods for the characterization of beer by nuclear magnetic resonance spectroscopy

Beer in Health and Disease Prevention
Gil AM, Rodrigues J
2008, 935-942, Elsevier.
ISBN: 978-0-12-373891-2

high resolution nmr tools for the analysis of beer and wine

In I A Farhat, Peter S Belton, G Webb (Eds.), Magnetic Resonance in Food Science: From Molecules to Man
Gil AM, Rodrigues J
2007, 96-104, Cambridge, RSC Pub.
ISBN: 978-0-85404-340-8

Techniques For Analyzing Wheat Proteins

In Cauvain SP (Eds.), Bread Making – Improving Quality
Gil A M
2004, 97-120, Woodhead Publishing Limited.

Application of NMR and Hyphenated Nmr Spectroscopy for the Study of Beer Components

In Webb GA, Belton PS, Gil AM, Rutledge DN (Eds.), Magnetic Resonance In Food Science - Latest Developments
P. S. Belton, A. M. Gil, G. A. Webb, D. Rutledge, I. F. Duarte, M. Spraul, M. Godejohann, U. Bruumann and A. M. Gil
2003, 151-157, Cambridge, The Royal Society Of Chemistry.
ISBN: 978-0-85404-886-1

Spectroscopy: Nuclear Magnetic Resonance

In Caballero B, Finglas P, Toldrá F (Eds.), Encyclopedia Of Food Sciences And Nutrition
Gil AM
2003, 545-547, Academic Press.
ISBN: 978-0122270550

Techniques For Analysing Wheat Proteins

In Cauvain SP (Eds.), Bread Making – Improving Quality
Gil AM
2003, 97-120, Woodhead Publishing Limited and CRC Press.
ISBN: 0-8493-1762-2

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