Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment

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abstract

In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies with Franz cells showed that the incorporation of caffeine in BC membranes provided lower permeation rates than those obtained with the conventional formulations. These results combined with the possibility of producing BC membranes with different shapes demonstrate that these materials are promising biosystems for topical delivery of caffeine, showing reproducibility and an extended and predictable caffeine release over time, leading to their potential use for cellulite attenuation.

keywords

IN-VITRO DIFFUSION; BACTERIAL CELLULOSE; BIOMATERIALS; FIBROBLASTS; LIDOCAINE; IBUPROFEN; POLYMERS; RELEASE; WOUNDS; SKIN

subject category

Materials Science; Polymer Science

authors

Silva, NHCS; Drumond, I; Almeida, IF; Costa, P; Rosado, CF; Neto, CP; Freire, CSR; Silvestre, AJD

our authors

foto Armando Jorge Domingues Silvestre

Armando Jorge Domingues Silvestre

Full professor
foto Carlos Pascoal Neto

Carlos Pascoal Neto

Raiz Director
foto Carmen Sofia da Rocha Freire Barros

Carmen Sofia da Rocha Freire Barros

Principal Researcher
foto Nuno Helder da Cruz Simões Silva

Nuno Helder da Cruz Simões Silva

Researcher

Groups

4 - Biorefineries, Biobased Materials and Recycling

Projects

Centre for Research in Ceramics and Composite Materials - CICECO (LA0011: 2013-2014) (PEst-C/CTM/LA0011/2013)
RMNE-UA-National Network of Electron Microscopy (REDE/1509/RME/2005 )
Laboratório de Análises Térmicas (REEQ/515/CTM/2005)

acknowledgements

The authors thank CICECO (Pest-C/CTM/LA0011/2013) and FCT for funding within the scope of the

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Publication Details

type
Journal Article
year
2014
journal
CELLULOSE
volume
21
publisher
SPRINGER
issn
0969-0239
issue
1
digital object identifier
10.1007/s10570-013-0114-1
web of science article identifier
WOS:000330807000053

Journal Metrics (JCR 2019)

Journal Impact Factor
4.21
Journal Impact Factor (5 yrs)
4.512
category normalized journal percentile
92.816

Citations

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