Production of Bioactive Nano-Hydroxyapatite/Polysaccharide Composites for Bone Tissue Engineering

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abstract

Porous K-carrageenan based composites with potential application in bone tissue engineering have been prepared by in situ co-precipitation of nanoparticles of calcium phosphates, followed by thermally induced gelification and freeze-drying. The scaffolds showed macroporous structure,with interconnected porosity. The variation of the biopolymer concentration affected the microstructure and compressive mechanical performance of the composites. The in vitro bioactivity was assessed by soaking the composites in simulated body fluid (SBF) and the formation of an apatite layer on their surface was found.

keywords

SCAFFOLDS

subject category

Engineering; Materials Science

authors

Daniel-da-Silva, AL; Gil, AM; Correia, RN

our authors

foto Ana Luísa Daniel da Silva

Ana Luísa Daniel da Silva

Auxiliary Researcher
foto Ana Maria Pissarra Coelho Gil

Ana Maria Pissarra Coelho Gil

Associate Professor with Aggregation

Groups

1 - Inorganic Functional Nanomaterials and Organic-Inorganic Hybrids
5 - Biomedical and Biomimetic Materials

acknowledgements

The help of Dr. J. A. T. Lopes-da-Silva in the execution of the compressive mechanical tests is gratefully acknowledged. A. L. Daniel-da-Silva thanks to CICECO (University of Aveiro, Portugal) for supporting this work.

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Publication Details

type
Journal Article
year
2008
journal
ADVANCED MATERIALS FORUM IV
volume
587-588
publisher
TRANS TECH PUBLICATIONS LTD
issn
0255-5476
web of science article identifier
WOS:000259898200005

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