Microwave assisted extraction of betulin from birch outer bark

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abstract

In this communication, we report a new method for the isolation of betulin, a triterpenoid with interesting pharmacological activities, from birch outer bark. Remarkably high purity betulin raw extracts were obtained, ca. 95 wt%, through microwave assisted extraction with limonene. This saves time and energy when compared to the conventional methods.

keywords

NATURAL-PRODUCTS; DRUG DISCOVERY; IONIC LIQUIDS; GREEN SOLVENT; PLANTS; PENDULA; SUBERIN; VACUUM; WASTE

subject category

Chemistry

authors

Ferreira, R; Garcia, H; Sousa, AF; Freire, CSR; Silvestre, AJD; Kunz, W; Rebelo, LPN; Pereira, CS

our authors

foto Andreia Fernandes de Sousa

Andreia Fernandes de Sousa

Auxiliary Researcher
foto Armando Jorge Domingues Silvestre

Armando Jorge Domingues Silvestre

Full professor
foto Carmen Sofia da Rocha Freire Barros

Carmen Sofia da Rocha Freire Barros

Principal Researcher

Groups

4 - Biorefineries, Biobased Materials and Recycling

Projects

Centre for Research in Ceramics and Composite Materials - CICECO (LA0011: 2011-2012) (PEst-C/CTM/LA0011/2011)
Creating value from bio-wastes: suberin extraction and biotransformation in biocompatible ionic liquids aiming on novel biomaterials and compounds (PTDC/QUI-QUI/120982/2010)
PTNMR - Portuguese Nuclear Magnetic Resonance Network (REDE/1517/RMN/2005)

acknowledgements

R. F. and A. F. S. are grateful to Fundacao para a Ciencia e a Tecnologia (FCT), Portugal, for the fellowships SFRH/BD/48286/2008 and SFRH/BPD/73383/2010, respectively; H. G. is indebted to Fundacao Calouste Gulbenkian, Portugal, for the fellowship 21-95587-B. The work was partially supported by FCT through the Grants PEst-OE/EQB/LA0004/2011, Pest-C/CTM/LA0011/2011, PTDC/QUI-QUI/120982/2010 and REDE/1517/RMN/2005, and by a cooperation grant from FCT and the Deutscher Akademischer Austauschdienst (DAAD).

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Publication Details

type
Journal Article
year
2013
journal
RSC ADVANCES
volume
3
publisher
ROYAL SOC CHEMISTRY
issn
2046-2069
issue
44
digital object identifier
10.1039/c3ra43868f
web of science article identifier
WOS:000326056600018

Journal Metrics (JCR 2019)

Journal Impact Factor
3.119
Journal Impact Factor (5 yrs)
3.098
category normalized journal percentile
59.04

Citations

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