Calcium phosphate granules for use as a 5-Fluorouracil delivery system

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abstract

The possibility of tailoring apatite granules as a controlled release system for the drug model 5-Fluorouracil (5FU) has been examined. Apatite granules (SDG) were obtained by spray drying suspensions of hydroxyapatite (HAP) nanoparticles previously precipitated from citrate solutions [M.A. Martins, C. Santos, M.E.V. Costa, M.M. Almeida, Preparation of porous hydroxyapatite particles to be used as drug delivery systems, Advanced Materials Forum 11 (455) (2004) 353-357]. SDG had donut shape and very high specific surface area (150 m(2)/g) indicative of high porosity. SDG were. poorly crystalline HAP but turned into biphasic granules (HSDG) with crystalline tricalcium phosphate and HAP after annealing at 800 degrees C, while reducing their surface area down to similar to 6 m(2)/g. SDG and HSDG were soaked in a 5FU solution at pH 5.2 and room temperature during several days and then transferred to a phosphate buffered solution (PBS) at pH 7.4 and 37 degrees C, for releasing 5FU. The comparison between the 5FU adsorbing and releasing behaviours exhibited by SDG and HSDG shows that engineering the granules characteristics, i.e. specific surface area, surface chemical composition, porosity and crystal phase composition allows the 5FU release profile to be controlled. (C) 2008 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

keywords

BETA-TRICALCIUM PHOSPHATE; HYDROXYAPATITE PARTICLES; DRUG-DELIVERY; MICROSPHERES; CELLS; NANOPARTICLES; BIOCERAMICS; BONE; FABRICATION; COMPOSITE

subject category

Materials Science

authors

Santos, C; Martins, MA; Franke, RP; Almeida, MM; Costa, MEV

our authors

foto Manuel António Martins da Silva

Manuel António Martins da Silva

Researcher
foto Maria Elisabete Jorge Vieira Costa

Maria Elisabete Jorge Vieira Costa

Assistant Professor
foto Maria Margarida Tavares Lopes Almeida

Maria Margarida Tavares Lopes Almeida

Emeritus Professor

Groups

1 - Inorganic Functional Nanomaterials and Organic-Inorganic Hybrids
2 - Multifunctional Ferroic Ceramics and Nanostructures
5 - Biomedical and Biomimetic Materials

acknowledgements

This work was supported in part by the European Project G5RD-CT2000-00282 Tissue Reactor.

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Publication Details

type
Journal Article
year
2009
journal
CERAMICS INTERNATIONAL
volume
35
publisher
ELSEVIER SCI LTD
issn
0272-8842
issue
4
digital object identifier
10.1016/j.ceramint.2008.08.015
web of science article identifier
WOS:000265007200041

Journal Metrics (JCR 2019)

Journal Impact Factor
3.83
Journal Impact Factor (5 yrs)
3.513
category normalized journal percentile
94.643

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