resumo
Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
palavras-chave
MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR
categoria
Chemistry; Science & Technology - Other Topics; Materials Science; Physics
autores
Bjorge, IM; Choi, IS; Correia, CR; Mano, JF
nossos autores
Clara R. Correia
Investigador
Isabel Bjørge
Estudante de doutoramento
João Mano
Professor CatedráticoProjectos
Bioengineered autonomous cell-biomaterials devices for generating humanised micro- tissues for regenerative medicine (ATLAS)
Regeneração Óssea Orquestrada pela Interação de Células do Sistema Imunitário com Microlaboratórios de Células e Microplataformas Padronizadas (CIRCUS)
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2019)
agradecimentos
I. M. Bjorge acknowledges the Portuguese Foundation for Science and Technology (FCT) with doctoral grant SFRH/BD/129224/2017. This work was financially supported by the European Research Council grant agreement ERC-2014-ADG-669858 (ATLAS) and FCT grant agreement PTDC/BTM-MAT/31064/2017 (CIRCUS). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. I. S. Choi acknowledges the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (MSIP 2012R1A3A2026403).