Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells

palavras-chave

ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; CLICK CHEMISTRY; IN-VITRO; DERIVATIVES; ANTICANCER; XANTHENE; DESIGN; 1,4-DIHYDROPYRIDINES; TRIETHYLAMINE

categoria

Chemistry

autores

Naouri, A; Djemoui, A; Ouahrani, MR; Lahrech, MB; Lemouari, N; Rocha, DHA; Albuquerque, H; Mendes, RF; Paz, FAA; Helguero, LA; Bachari, K; Talhi, O; Silva, AMS

nossos autores

agradecimentos

Thanks are due to FCT/MEC for the financial support for the project PT-DZ/0005 and of the QOPNA research Unit (FCT UID/QUI/00062/2019) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Part of this work was also developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. We would like to thank the General Directorate for Scientific Research and Technological Development e DGRSDTof Algeria and Agence Th~ematique de Recherche en Sciences et Technologie ATRST for approving the co-financed bilateral project PT-DZ/0005. We further wish to thank CICECO for funding the purchase of the single-crystal X-ray diffractometer. RFM gratefully acknowledges FCT for a Junior Research Position (CEECIND/00553/2017). The authors are thankful to Pr. Farid Messelmi the Dean of Faculty of Exact Sciences and informatics in Djelfa University, for providing necessary laboratory facilities.

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