Mara Guadalupe Freire Martins

Investigador Coordenador

Contacto

Departamento

  • Química
  • 29.3.33

Investigação

Ligações

Últimas Notícias

Perfil biográfico

Mara G. Freire graduated in Chemistry in 2003 by University of Aveiro, Portugal, receiving the “Best Chemistry Student Award” from Dow Portugal. By the end of 2007 she completed her PhD in Chemical Engineering by University of Aveiro, with trainees at Federal University of Rio de Janeiro, Brazil, and Claude Bernard University, Lyon, France, followed by post-doctoral activities at ITQB2, New University of Lisbon, Portugal. In 2012, Freire was an invited professor at Tiradentes University, Sergipe, Brazil. From June 2013 to January 2014, Freire was an Assistant Researcher at CICECO - Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Portugal, and since February 2014 she is a Coordinator Researcher at the same institution. Currently, Freire is the Coordinator of Group 5 of CICECO, Biomedical and Biomimetic Materials, and Deputy Chair of the Scientific Council of University of Aveiro. She is member of the Young Scientists Seminar of the Lisbon Academy of Sciences.

Freire published +250 papers in international peer reviewed journals, 20 book chapters and edited one book, and has +13,500 citations and h-index of 66. She has published in scientific journals such as Chem. Rev., Chem. Soc. Rev., Angew. Chem., Phys. Chem. Lett., Adv. Sci., Sci. Rep., Green Chem., Chem. Eur. J., ACS Sustain. Chem. Eng., Phys. Chem. Chem. Phys., Biotechnol. Bioeng., Biotechnol. J., Sep. Purif. Technol., among others. The scientific network and internationalization of Freire is supported by publications with +200 distinct authors with diverse national/international affiliations. Freire recurrently acts as a referee of several journals, as well as in European and international programmes for independent research careers and research projects. Freire coordinated/participated in +20 R&D projects, among which a Starting and a Proof of Concept Grants from the European Research Council (ERC). She has filled +10 national/international patents, and is the co-founder of the RYAPUTECH spin-off.

In addition to other awards and recognitions, Freire received the ECTP-NETZSCH Young Scientist Award in 2014, was recognized amongst the top 20 “Women in Science” in Portugal in 2016, was recognized as one of the 14 rising stars in the Green Chemistry field by the Green Chemistry journal in 2017, was recognized as one of the 100 women in Chemistry by the Royal Society of Chemistry in 2018, was awarded with the “Vicente de Seabra Medal” in 2018, and was recognized as an influential researcher by the journal Industrial Research and Chemical Engineering and as a highly cited researcher by the Journal of Chemical and Engineering Data of the American Chemical Society in 2019. She received the Born from Knowledge award by Agência Nacional de Inovação in the Health field in 2018 and was a finalist in the Everis Awards 2019, awards related with technology transfer and business ideas.

The pedagogical capacity of Freire is supported by recurrent teaching activities of Physical Chemistry and Alternative Solvents Technologies at the University of Aveiro. Up to date, she has completed the supervision of 18 post-doctoral researchers, and 13 PhD, 50 MSc and 40 BSc students.

Interesses científicos

Freire performs research in the following scientific domains: Biotechnology, Chemical Engineering/Bioengenering, Chemistry/Physical Chemistry and Health Sciences. Her research interests cover the following topics:

Development of cost-effective purification processes for high-value biopharmaceuticals

The production cost of high-quality biopharmaceuticals for large-scale applications still remains higher than other drug therapies due to the current lack of efficient purification strategies. To overcome this drawback, we are focused on the development of cost-effective purification processes for several value-added biopharmaceuticals, namely antibodies, recombinant proteins, and nucleic-acids-based products. Simultaneously to the development of separation processes, we are also working on the optimization of immunization protocols and on the biopharmaceuticals production.

Development of efficient pre-treatment techniques for biological samples envisaging early-stage diagnoses

The early detection of some diseases, including cancer, is pivotal and can increase their therapeutic success rate. Nowadays, there are some well-known biomarkers which are indicative of the presence of cancer or other diseases; yet, in most situations, their concentrations in human fluids, such as in urine and serum, are well below the detection limit of the currently used analytical equipment. To overcome these limitations, our research team is focused on the development of pre-treatment strategies for biological fluids (simultaneous purification and concentration approaches) to improve the detection and quantification of several diseases biomarkers.  

Development of sustainable recovery processes for high-value compounds with therapeutic properties from biomass

The consumption of natural compounds with therapeutic features is highly advantageous compared to their synthetic counterparts (which usually lead to adverse effects). However, these products are typically extracted by volatile and often toxic solvents, and obtained with low yields and low purity levels. Trying to overcome these drawbacks, we have been investigating the use of aqueous solutions of ionic liquids and deep eutectic solvents as alternative solvents for the selective extraction of target compounds, mainly with therapeutic features from biomass, as well as from biomass by-products and wastes. Attempts on integrated/biorefinery approaches, always bearing in mind the new challenges of the circular economy and the need to reduce and reuse waste and raw materials, are priority issues in this line of research. The cytotoxicity and biological activities of the extracted compounds also are usually appraised. 

Synthesis and applications of ionic liquids as therapeutic drugs

Several therapeutic drugs exhibit low solubility in biological fluids, displaying thus low bioavailability, and sometimes requiring the use of vehicles for drug delivery which, in turn, may be toxic. To overcome these drawbacks, we are focused on the synthesis of novel ionic-liquid-based drugs with analgesic, anti-inflammatory and/or antioxidant activities for pharmaceutical and medical applications, and on the evaluation of their in vitro and in vivo toxicity and their neuroprotection capacity. These novel drugs display a high potential to prevent neurodegeneration-based conditions, such as Parkinson’s and Alzheimer’s diseases. 

Publicações seleccionadas

  1. Passos, H.; Costa, S. H.; Fernandes, A. M.; Freire, M. G.; Rogers, R. D.; Coutinho, J. A. P., “A Triple Salting-Out Effect is Required for the Formation of Ionic-Liquid-Based Aqueous Multiphase Systems”, Angew. Chem. Int. Edit. 56 (2017) 15058-15062. 
  2. e Silva, F. A.; Pereira, J. F. B.; Kurnia, K. A.; Ventura, S. P. M.; Silva, A. M. S.; Rogers, R. D.; Coutinho, J. A. P.; Freire, M. G., “Temperature Dependency of Aqueous Biphasic Systems: an Alternative Approach for Exploring the Differences between Coulombic-dominated Salts and Ionic Liquids”, Chem. Commun. 53 (2017) 7298-7301.
  3. Ferreira, A. M.; Cláudio, A. F. M.; Valega, M.; Domingues, F. M. J.; Silvestre, A. J. D.; Rogers, R. D.; Coutinho, J.A.P.; Freire, M. G., “Switchable (pH-driven) aqueous biphasic systems formed by ionic liquids as integrated production-separation platforms”. Green Chem. 19 (2017) 2768-27773.
  4. Neves, C. M. S. S.; Silva, A. M. S.; Fernandes, A. M.; Coutinho, J. A. P.; Freire, M.G., “Towards an Understanding of the Mechanisms behind the Formation of Liquid-Liquid Systems formed by Two Ionic Liquids”, J. Phys. Chem. Lett. 8 (2017) 3015-3019.
  5. Ventura, S. P. M.; Silva, F. A.; Quental, M. V.; Mondal, D.; Freire, M. G.; Coutinho, J. A. P., “Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends”, Chem. Rev. (2017) 6984-7052. 
  6. Capela, E. V.; Quental, M. V.; Domingues, P.; Coutinho, J. A. P.; Freire, M. G., “Effective Separation of Aromatic and Aliphatic Amino Acids Mixtures using Ionic-Liquid-based Aqueous Biphasic Systems”, Green Chem. 19 (2017) 1850-1854.
  7.  Mondal, D.; Sharma, M.; Quental, M. V.; Tavares, A. P. M.; Prasad, K.; Freire, M. G., “Suitability of Bio-Based Ionic Liquids for the Extraction and Purification of IgG Antibodies”, Green Chem. 18 (2016) 6071-6081.
  8. Passos, H.; Luís, A.; Coutinho, J. A. P.; Freire, M. G., “Thermoreversible (Ionic-Liquid-Based) Aqueous Biphasic Systems”, Sci. Rep. 6 (2016) Article number: 20276.
  9. Dinis, T. B. V.; Passos, H.; Lima, D. L. D.; Esteves, V. I.; Coutinho, J. A. P.; Freire, M. G., “One-step Extraction and Concentration of Estrogens for an Adequate Monitoring of Wastewaters Using Ionic-Liquid-Based Aqueous Biphasic Systems”, Green Chem. 17 (2015) 2570–2579
  10. Taha, M.; Almeida, M. R.; Silva, F. A.; Domingues, P.; Ventura, S. P. M.; Coutinho, J. A. P.; Freire, M. G., “Novel Biocompatible and Self-buffering Ionic Liquids for Biopharmaceutical Applications”, Chem. Eur. J. 21 (2015) 4781–4788.
  11. Passos, H.; Freire, M. G.; Coutinho, J. A. P., “Ionic liquid Solutions as Extractive Solvents for Value-Added Compounds from Biomass”, Green Chem. 16 (2014) 4786-4815.
  12. Cláudio, A. F. M.; Swift, L.; Hallett, J.; Welton, T.; Coutinho, J. A. P.; Freire, M. G., “Extended Scale for the Hydrogen-Bond Basicity of Ionic Liquids”,  Phys. Chem. Chem. Phys. 16 (2014) 6593-6601.
  13. Pereira, J. F. B.; Rebelo, L. P. N.; Rogers, R. D.; Coutinho, J. A. P.; Freire, M. G., “Combining Ionic Liquids and Polyethylene Glycols to Boost the Hydrophobic-hydrophilic Range of Aqueous Biphasic Systems”, Phys. Chem. Chem. Phys. 15 (2013) 19580-19583.
  14. Freire, M. G.; Cláudio, A. F. M.; Araújo, J. M. M.; Coutinho, J. A. P.; Marrucho, I. M.; Canongia Lopes, J. N.; Rebelo, L. P. N., “Aqueous Biphasic Systems: A Boost Brought About by using Ionic Liquids”, Chem. Soc. Rev. 41 (2012) 4966-4995.
  15. Tariq, M.; Freire, M.G.; Saramago, B.; Coutinho, J. A. P.; Canongia Lopes, J. N.; Rebelo, L. P. N., “Surface Tension of Ionic Liquids and Ionic Liquid Solutions”, Chem. Soc. Rev. 41 (2012) 829-868.
  16. Freire, M. G.; Pereira, J. F. B.; Francisco, M.; Rodríguez, H.; Rebelo, L. P. N.; Rogers, R. D.; Coutinho, J. A. P., “Insights into the Interactions that Control the Phase Behaviour of Novel Aqueous Biphasic Systems Composed of Polyethylene Glycols and Ionic Liquids”, Chem. Eur. J. 18 (2012) 1831-1839.
  17. Freire, M. G.; Neves, C. M. S. S.; Marrucho, I. M.; Canongia Lopes, J. N.; Rebelo, L. P. N.; Coutinho, J. A. P., “High-Performance Extraction of Alkaloids using Aqueous Two-Phase Systems with Ionic Liquids”, Green Chem. 12 (2010) 1715-1718.
  18. Freire, M. G.; Neves, C. M. S. S.; Carvalho, P. J.; Gardas, R. M.; Fernandes, A. M.; Marrucho, I. M.; Santos, L. M. N. B. F.; Coutinho, J. A. P., “Mutual Solubilities of Water and Hydrophobic Ionic Liquids”, J. Phys. Chem. B 111 (2007) 13082-13089.
  19. Freire, M. G.; Gomes, L.; Santos, L. M. N. B. F.; Marrucho, I. M., Coutinho, J. A. P., “Water Solubility in Linear Fluoroalkanes Used in Blood Substitute Emulsions”, J. Phys. Chem. B 110 (2006) 22923-22929.
  20. Freire, M. G.; Dias, A. M. A.; Coelho, M. A. Z.; Coutinho, J. A. P.;Marrucho, I. M., “Aging Mechanisms of Perfluorocarbon Emulsions using Image Analysis”, J. Colloid Interface Sci. 286 (2005) 224-232.

Supervisões em Curso

Ana Catarina Almeida Sousa

Investigador

Projectos

Aplicação de SAB constituídos por líquidos iónicos no desenvolvimento de diagnósticos de câncer do sistema adrenalina (MCT/CNPq 14/2010 Universal)

Coordenador LocalOther International

Arejamento de reactores biológicos multifásicos (POCTI/EQU/44427/2002)

ParticipanteFundação para a Ciência e a Tecnologia
Reactores biológicos Arejamento Multifásico Perfluorocarbonetos

DeepBiorefinery - Solventes Eutéticos Profundos Naturais: Uma Plataforma para Promover a Biorefinaria integrada baseada em Eucalyptus globulus e na cortiça de Quercus suber (DeepBiorefinery )

ParticipanteFundação para a Ciência e a Tecnologia
natural deep eutetic solvents, biorefinery, green separation processes

Desenvolvimento de dispositivos baseados em líquidos iónicos para a remoção de citostáticos de urina excretados por pacientes oncológicos (IonCytDevice)

CoordenadorFundação para a Ciência e a Tecnologia

Desenvolvimento de nanomateriais sustentáveis para a purificação de fármacos anti-leucémicos (NanoPurAsp)

ParticipanteFundação para a Ciência e a Tecnologia

Desenvolvimento de Novos Sistemas para Terapêutica de Oxigénio: Utilização de Líquidos Iónicos Fluorados (PTDC/EQU-FTT/118800/2010)

Coordenador LocalFundação para a Ciência e a Tecnologia
Fluorinated Ionic Liquids Perfluoroalkanes Phase Equilibria Oxygen Solubility

Desenvolvimento de uma tecnologia sustentável para a extração e purificação de clorofilas a partir de biomassa (EXPL/QEQ-PRS/0224/2013 )

ParticipanteFundação para a Ciência e a Tecnologia
clorofila extração biomassa líquidos iónicos

Determinação de Parâmetros Básicos para o Desenvolvimento de Modelos Fundamentais em Sistemas de Sais Líquidos (PTDC/QUI/72903/2006)

ParticipanteFundação para a Ciência e a Tecnologia
Líquidos iónicos Pressão de vapor Entalpias de evaporação Equilíbrio Líquido Vapor

Equilíbrio líquido vapor de líquidos iónicos puros e suas misturas com solventes orgânicos (PTDC/EQU-FTT/65252/2006)

ParticipanteFundação para a Ciência e a Tecnologia
Líquidos Iónicos Pressão de Vapor Entalpias e entropias de vaporização molares Equilíbrio Líquido Vapor

EXIL - Exchange on Ionic Liquids (EXIL)

ParticipanteEuropean Comission
The objective of this Action is to coordinate European research activities and knowledge exchange on ionic liquids (ILs, low melting salts, many of them liquid at room temperature and below) and to explore their full potential in the context of fundamental and applied chemistry, materials science and engineering. The COST Action will provide a c...

Extraction and Purification of Biomolecules (FAPITEC/FUNTEC/CNPq n. 10/2011)

Coordenador LocalOther International

Igy Technology: A Purication Platform using Ionic-Liquid-Based Aqueous Biphasic Systems (IGYPURTECH)

CoordenadorEuropean Comission
With the emergence of antibiotic-resistant pathogens the development of antigen-specific antibodies for use in passive immunotherapy is, nowadays, a major concern in human society. Despite the most focused mammal antibodies, antibodies obtained from egg yolk of immunized hens, immunoglobulin Y (IgY), are an alternative option that can be obtaine...

Liquidos Iónicos como Principios Activos (PTDC/EQU-EPR/104554/2008)

Coordenador LocalFundação para a Ciência e a Tecnologia
Ionic Liquids Fluoroquinolones Bioavailability Solubility related properties

Liquidos iónicos e a génese de sistemas aquosos bisáficos: equilibrio entre interações ve van der waals e electrostáticas (PTDC/QUI-QUI/121520/2010)

ParticipanteFundação para a Ciência e a Tecnologia
Aqueous Biphasic System Ionic Liquid Inorganic Salt Polymer

Melhorias no bioprocessamento de proteínas recombinantes utilizando líquidos iónicos (IL2BioPro)

ParticipanteFundação para a Ciência e a Tecnologia

MultiBiorefinery - Estratégias multiuso para a valorização de uma gama alargada de subprodutos agroflorestais e das pesacas: um passo em frente na criação de uma biorrefinaria integrada (SAICTPAC/0040/2015)

ParticipanteFundação para a Ciência e a Tecnologia

Nanoestruturas de ZnO e compósitos ZnO/nanocarbono para aplicação em biossensores (NANOBIOSENSE)

ParticipanteFundação para a Ciência e a Tecnologia
The expanding interest regarding biosensing and early diseases’ diagnosis has led to an exponential growth of R&D efforts in order to find the most suitable materials and sensing mechanisms to achieve high sensitivity and selectivity at low production cost. In this framework, the present project envisages the development of ZnO-based nanostructu...

Otimização e aumento de escala de processos com líquidos iônicos como nova ferramenta de purificação da proteína verde fluorescente recombinante produzida por Escherichia coli "GFPurIL" (FAPESP/19793/2014)

ParticipanteFundação para a Ciência e a Tecnologia
biopharmaceuticals, fluorescent proteins, purification, aqueous biphasic systems

Propriedades de Superfície e Equilíbrio de Fases de Sistemas Água + Óleo (POCI/EQU/58239/2004)

ParticipanteFundação para a Ciência e a Tecnologia
Equilíbrio de Fases Tensão Interfacial Sistemas Aquosos Modelação

SGH : Smart Green Homes (Smart Green Homes)

ParticipanteIndustry National
O Projeto Smart Green Homes (SGH) visa desenvolver soluções integradas de produtos e tecnologias para ambiente doméstico, elevando os padrões de conforto, segurança e satisfação de utilização a um novo nível e, ao mesmo tempo, dar resposta aos problemas de sustentabilidade do planeta, aumentando a eficiência energética e diminuindo as emissões d...

Suportes Modificados com liquidos Iónicos para a Purificação de Pré-MirNas envolvidos na doença de Alzheimer. (PUREmiRSILs)

Coordenador LocalFundação para a Ciência e a Tecnologia

Towards the use of IgY antibodies as alternative therapeutics (PureIgY)

CoordenadorEuropean Comission
Immunoglobulins (or antibodies) are molecules produced by our white blood cells; the immunoglobins recognise 'invaders' and aid in their destruction. Humans make five different classes, one of which is similar in function to IgY, an unusual antibody made by chickens. The circulating IgY accumulates in the yolk of chicken eggs. This is convenient...

Publicações

Preface

Freire, MG; Coutinho, JAP
2020, FLUID PHASE EQUILIBRIA, 512.
ISBN: 1879-0224

Distinct roles of salt cations and anions upon the salting-out of electro-positive albumin

Madeira, PP; Freire, MG; Coutinho, JAP
2020, JOURNAL OF MOLECULAR LIQUIDS, 301.
ISBN: 1873-3166

Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

Chantereau, G; Sharma, M; Abednejad, A; Vilela, C; Costa, EM; Veiga, M; Antunes, F; Pintado, MM; Sebe, G; Coma, V; Freire, MG; Freire, CSR; Silvestre, AJD
2020, JOURNAL OF MOLECULAR LIQUIDS, 302.
ISBN: 1873-3166

Aqueous biphasic systems comprising copolymers and cholinium-based salts or ionic liquids: Insights on the mechanisms responsible for their creation

Dimitrijevic, A; Tavares, APM; Jocic, A; Maric, S; Trtic-Petrovic, T; Gadzuric, S; Freire, MG
2020, SEPARATION AND PURIFICATION TECHNOLOGY, 248.
ISBN: 1873-3794

Aqueous two-phase systems: Towards novel and more disruptive applications

Pereira, JFB; Freire, MG; Coutinho, JAP
2020, FLUID PHASE EQUILIBRIA, 505.
ISBN: 1879-0224

Enhanced Conversion of Xylan into Furfural using Acidic Deep Eutectic Solvents with Dual Solvent and Catalyst Behavior

Morais, ES; Freire, MG; Freire, CSR; Coutinho, JAP; Silvestre, AJD
2020, CHEMSUSCHEM, 13, 4, 784-790.
ISBN: 1864-564X

Enhanced Extraction of Levodopa from Mucuna pruriens Seeds Using Aqueous Solutions of Eutectic Solvents

Benfica, J; Miranda, JS; Morais, ES; Freire, MG; Coutinho, JAP; de Sousa, RDS
2020, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8, 17, 6682-6689.

Enhanced performance of polymer-polymer aqueous two-phase systems using ionic liquids as adjuvants towards the purification of recombinant proteins

Castro, LS; Pereira, P; Passarinha, LA; Freire, MG; Pedro, AQ
2020, SEPARATION AND PURIFICATION TECHNOLOGY, 248.
ISBN: 1873-3794

Extraction of High Value Triterpenic Acids from Eucalyptus globulus Biomass Using Hydrophobic Deep Eutectic Solvents

Silva, NHCS; Morais, ES; Freire, CSR; Freire, MG; Silvestre, AJD
2020, MOLECULES, 25, 1.
ISBN: 1420-3049

Hybrid alginate-protein cryogel beads: efficient and sustainable bio-based materials to purify immunoglobulin G antibodies

Sharma, M; Tavares, APM; Nunes, JCF; Singh, N; Mondal, D; Neves, MC; Prasad, K; Freire, MG
2020, GREEN CHEMISTRY, 22, 7, 2225-2233.
ISBN: 1463-9270

Performance of tetraalkylammonium-based ionic liquids as constituents of aqueous biphasic systems in the extraction of ovalbumin and lysozyme

Belchior, DCV; Quental, MV; Pereira, MM; Mendonca, CMN; Duarte, IF; Freire, MG
2020, SEPARATION AND PURIFICATION TECHNOLOGY, 233.
ISBN: 1873-3794

Supported ionic liquids as efficient materials to remove non-steroidal anti-inflammatory drugs from aqueous media

Almeida, HFD; Neves, MC; Trindade, T; Marrucho, IM; Freire, MG
2020, CHEMICAL ENGINEERING JOURNAL, 381.
ISBN: 1873-3212

Supported Ionic Liquids for the Efficient Removal of Acetylsalicylic Acid from Aqueous Solutions

Bernardo, SC; Araujo, BR; Sousa, ACA; Barros, RA; Cristovao, AC; Neves, MC; Freire, MG
2020, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2020, 24, 2380-2389.
ISBN: 1099-0682

Valorization of Expired Energy Drinks by Designed and Integrated Ionic Liquid-Based Aqueous Biphasic Systems

Dimitrijevic, A; Tavares, APM; Almeida, MR; Vranes, M; Sousa, ACA; Cristovao, AC; Trtic-Petrovic, T; Gadzuric, S; Freire, MG
2020, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8, 14, 5683-5692.

Insights on the DNA Stability in Aqueous Solutions of Ionic Liquids

Dinis, TBV; Sousa, F; Freire, MG
2020, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8.

Development and characterization of a novell-asparaginase/MWCNT nanobioconjugate

Cristovao, RO; Almeida, MR; Barros, MA; Nunes, JCF; Boaventura, RAR; Loureiro, JM; Faria, JL; Neves, MC; Freire, MG; Ebinuma-Santos, VC; Tavares, APM; Silva, CG
2020, RSC ADVANCES, 10, 52, 31205-31213.
ISBN: 2046-2069

Towards the differential diagnosis of prostate cancer by the pre-treatment of human urine using ionic liquids

Pereira, MM; Calixto, JD; Sousa, ACA; Pereira, BJ; Lima, AS; Coutinho, JAP; Freire, MG
2020, SCIENTIFIC REPORTS, 10, 1.

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Pedro, SN; Freire, CSR; Silvestre, AJD; Freire, MG
2020, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 21.
ISBN: 1422-0067

Use of Ionic Liquids and Deep Eutectic Solvents in Polysaccharides Dissolution and Extraction Processes towards Sustainable Biomass Valorization

Morais, ES; Lopes, AMD; Freire, MG; Freire, CSR; Coutinho, JAP; Silvestre, AJD
2020, MOLECULES, 25, 16.
ISBN: 1420-3049

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Morais, ES; Silva, NHCS; Sintra, TE; Santos, SAO; Neves, BM; Almeida, IF; Costa, PC; Correia-Sa, I; Ventura, SPM; Silvestre, AJD; Freire, MG; Freire, CSR
2019, CARBOHYDRATE POLYMERS, 206, 187-197.
ISBN: 1879-1344

Binary Mixtures of Ionic Liquids in Aqueous Solution: Towards an Understanding of Their Salting-In/Salting-Out Phenomena

Neves, CMSS; Dinis, TBV; Carvalho, PJ; Schroder, B; Santos, LMNBF; Freire, MG; Coutinho, JAP
2019, JOURNAL OF SOLUTION CHEMISTRY, 48, 7, 983-991.
ISBN: 1572-8927

Synthesis and characterization of analogues of glycine-betaine ionic liquids and their use in the formation of aqueous biphasic systems

Pereira, MM; Pedro, SN; Gomes, J; Sintra, TE; Ventura, SPM; Coutinho, JAP; Freire, MG; Mohamadou, A
2019, FLUID PHASE EQUILIBRIA, 494, 239-245.
ISBN: 1879-0224

Simultaneous Separation of Antioxidants and Carbohydrates From Food Wastes Using Aqueous Biphasic Systems Formed by Cholinium-Derived Ionic Liquids

Neves, CMSS; Figueiredo, M; Reis, PM; Sousa, ACA; Cristovao, AC; Fiadeiro, MB; Rebelo, LPN; Coutinho, JAP; Esperanca, JMSS; Freire, MG
2019, FRONTIERS IN CHEMISTRY, 7.

Integrated Extraction-Preservation Strategies for RNA Using Biobased Ionic Liquids

Quental, MV; Pedro, AQ; Pereira, P; Sharma, M; Queiroz, JA; Coutinho, JAP; Sousa, F; Freire, MG
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 10, 9439-9448.

Odd-Even Effect in the Formation and Extraction Performance of Ionic-Liquid-Based Aqueous Biphasic Systems

Belchior, DCV; Almeida, MR; Sintra, TE; Ventura, SPM; Duarte, IF; Freire, MG
2019, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 58, 19, 8323-8331.

Solvatochromism as a new tool to distinguish structurally similar compounds

Madeira, PP; Loureiro, JA; Freire, MG; Coutinho, JAP
2019, JOURNAL OF MOLECULAR LIQUIDS, 274, 740-745.
ISBN: 1873-3166

Understanding the effect of ionic liquids as adjuvants in the partition of biomolecules in aqueous two-phase systems formed by polymers and weak salting-out agents

Neves, CMSS; Sousa, RDS; Pereira, MM; Freire, MG; Coutinho, JAP
2019, BIOCHEMICAL ENGINEERING JOURNAL, 141, 239-246.
ISBN: 1873-295X

Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems

Pedro, SN; Freire, MG; Freire, CSR; Silvestre, AJD
2019, EXPERT OPINION ON DRUG DELIVERY, 16, 5, 497-506.
ISBN: 1744-7593

Liquid-Liquid Equilibrium and Extraction Performance of Aqueous Biphasic Systems Composed of Water, Cholinium Carboxylate Ionic Liquids and K2CO3

Almeida, MR; Belchior, DCV; Carvalho, PJ; Freire, MG
2019, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 64, 11, 4946-4955.
ISBN: 1520-5134

Continuous separation of cytochrome-c PEGylated conjugates by fast centrifugal partition chromatography

Santos, JHPM; Ferreira, AM; Almeida, MR; Quinteiro, PSGN; Dias, ACRV; Coutinho, JAP; Freire, MG; Rangel-Yagui, CO; Ventura, SPM
2019, GREEN CHEMISTRY, 21, 20, 5501-5506.
ISBN: 1463-9270

Sustainable strategies based on glycine-betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatants

Capela, EV; Santiago, AE; Rufino, AFCS; Tavares, APM; Pereira, MM; Mohamadou, A; Aires-Barros, MR; Coutinho, JAP; Azevedo, AM; Freire, MG
2019, GREEN CHEMISTRY, 21, 20, 5671-5682.
ISBN: 1463-9270

Enhanced Activity of Immobilized Lipase by Phosphonium-Based Ionic Liquids Used in the Support Preparation and Immobilization Process

Barbosa, MS; Santos, AJ; Carvalho, NB; Figueiredo, RT; Pereira, MM; Lima, AS; Freire, MG; Cabrera-Padilla, RY; Soares, CMF
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 18, 15648-15659.

Use of Ionic Liquids as Cosurfactants in Mixed Aqueous Micellar Two-Phase Systems to Improve the Simultaneous Separation of Immunoglobulin G and Human Serum Albumin from Expired Human Plasma

Vicente, FA; Bairos, J; Roque, M; Coutinho, JAP; Ventura, SPM; Freire, MG
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 17, 15102-15113.

Design of Nonsteroidal Anti-Inflammatory Drug-Based Ionic Liquids with Improved Water Solubility and Drug Delivery

Chantereau, G; Sharma, M; Abednejad, A; Neves, BM; Sebe, G; Coma, V; Freire, MG; Freire, CSR; Silvestre, AJD
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 16, 14126-14134.

Recovery of Syringic Acid from Industrial Food Waste with Aqueous Solutions of Ionic Liquids

de Faria, ELP; Ferreira, AM; Claudio, AFM; Coutinho, JAP; Silvestre, AJD; Freire, MG
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 16, 14143-14152.

Editorial overview: A closer look on sustainable solvents and processes

Freire, MG; Coutinho, JAP
2019, CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, 18, A4-A6.

Effects of phosphonium-based ionic liquids on the lipase activity evaluated by experimental results and molecular docking

Barbosa, MS; Freire, CCC; Souza, RL; Cabrera-Padilla, RY; Pereira, MM; Freire, MG; Lima, AS; Soares, CMF
2019, BIOTECHNOLOGY PROGRESS, 35, 4.
ISBN: 1520-6033

Laccase Activation in Deep Eutectic Solvents

Toledo, ML; Pereira, MM; Freire, MG; Silva, JPA; Coutinho, JAP; Tavares, APM
2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7, 13, 11806-11814.

Nanocellulose membranes loaded with antioxidant phenolic compounds formulated as ionic liquids: from preparation to in vitro anti-inflammatory assessment.

Morais, E; Silva, N; Santos, S; Neves, B; Almeida, I; Costa, P; Correia-Sa, I; Ventura, S; Silvestre, A; Freire, M; Freire, C
2019, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257.

Polyvinylidene fluoride-Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior

Abednejad, A; Ghaee, A; Morais, ES; Sharma, M; Neves, BM; Freire, MG; Nourmohammadi, J; Mehrizi, AA
2019, ACTA BIOMATERIALIA, 100, 142-157.
ISBN: 1878-7568

Ionic Liquids in Bioseparation Processes

Belchior, DCV; Duarte, IF; Freire, MG
2019, APPLICATION OF IONIC LIQUIDS IN BIOTECHNOLOGY, 168, 1-29.
ISBN: 1616-8542

A simple approach for the determination and characterization of ternary phase diagrams of aqueous two-phase systems composed of water, polyethylene glycol and sodium carbonate.

Capela, Emanuel V; Santos, Joao H P M; Boal-Palheiros, Isabel; Coutinho, Joao A P; Ventura, Sonia P M; Freire, Mara G
2019, CHEMICAL ENGINEERING EDUCATION, 53, 2, 112-120.
ISBN: 2165-6428

Progress in the Development of Aqueous Two-Phase Systems Comprising Ionic Liquids for the Downstream Processing of Protein-Based Biopharmaceuticals

Castro, L. S.; Pereira, P.; Freire, M. G.; Pedro, A. Q.
2019, American Pharmaceutical Review.

Simultaneous extraction and concentration of water pollution tracers using ionic-liquid-based systems

Dinis, TBV; Passos, H; Lima, DLD; Sousa, ACA; Coutinho, JAP; Esteves, VI; Freire, MG
2018, JOURNAL OF CHROMATOGRAPHY A, 1559, 69-77.

Cloud Point Extraction of Chlorophylls from Spinach Leaves Using Aqueous Solutions of Nonionic Surfactants

Leite, AC; Ferreira, AM; Morais, ES; Khan, I; Freire, MG; Coutinho, JAP
2018, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 6, 1, 590-599.

Stimuli responsive ion gels based on polysaccharides and other polymers prepared using ionic liquids and deep eutectic solvents

Prasad, K; Mondal, D; Sharma, M; Freire, MG; Mukesh, C; Bhatt, J
2018, CARBOHYDRATE POLYMERS, 180, 328-336.

Mechanisms ruling the partition of solutes in ionic-liquid-based aqueous biphasic systems - the multiple effects of ionic liquids

Passos, H; Dinis, TBV; Capela, EV; Quental, MV; Gomes, J; Resende, J; Madeira, PP; Freire, MG; Coutinho, JAP
2018, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20, 13, 8411-8422.

Economic evaluation of the primary recovery of tetracycline with traditional and novel aqueous two-phase systems

Torres-Acosta, MA; Pereira, JFB; Freire, MG; Aguilar-Yanez, JM; Coutinho, JAP; Titchener-Hooker, NJ; Rito-Palomares, M
2018, SEPARATION AND PURIFICATION TECHNOLOGY, 203, 178-184.

Separation of immunoglobulin G using aqueous biphasic systems composed of cholinium-based ionic liquids and poly(propylene glycol)

Ramalho, CC; Neves, CMSS; Quental, MV; Coutinho, JAP; Freire, MG
2018, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 93, 7, 1931-1939.

Potential of aqueous two-phase systems for the separation of levodopa from similar biomolecules

Sousa, RDS; Neves, CMSS; Pereira, MM; Freire, MG; Coutinho, JAP
2018, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 93, 7, 1940-1947.

Hydrogen bond basicity of ionic liquids and molar entropy of hydration of salts as major descriptors in the formation of aqueous biphasic systems

Passos, H; Dinis, TBV; Claudio, AFM; Freire, MG; Coutinho, JAP
2018, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20, 20, 14234-14241.

Odd-even effect on the formation of aqueous biphasic systems formed by 1-alkyl-3-methylimidazolium chloride ionic liquids and salts

Belchior, DCV; Sintra, TE; Carvalho, PJ; Soromenho, MRC; Esperanca, JMSS; Ventura, SPM; Rogers, RD; Coutinho, JAP; Freire, MG
2018, JOURNAL OF CHEMICAL PHYSICS, 148, 19.

Evaluation of the effect of ionic liquids as adjuvants in polymer-based aqueous biphasic systems using biomolecules as molecular probes

Sousa, RDS; Pereira, MM; Freire, MG; Coutinho, JAP
2018, SEPARATION AND PURIFICATION TECHNOLOGY, 196, 244-253.

Separation of phenolic compounds by centrifugal partition chromatography

Santos, JHPM; Almeida, MR; Martins, CIR; Dias, ACRV; Freire, MG; Coutinho, JAP; Ventura, SPM
2018, GREEN CHEMISTRY, 20, 8, 1906-1916.

An integrated process for enzymatic catalysis allowing product recovery and enzyme reuse by applying thermoreversible aqueous biphasic systems

Ferreira, AM; Passos, H; Okafuji, A; Tavares, APM; Ohno, H; Freire, MG; Coutinho, JAP
2018, GREEN CHEMISTRY, 20, 6, 1218-1223.

Deep Eutectic Solvent Aqueous Solutions as Efficient Media for the Solubilization of Hardwood Xylans

Morais, ES; Mendonca, PV; Coelho, JFJ; Freire, MG; Freire, CSR; Coutinho, JP; Silvestre, AJD
2018, CHEMSUSCHEM, 11, 4, 753-762.

Aqueous biphasic systems in the separation of food colorants

Santos, JHPM; Capela, EV; Boal-Palheiros, I; Coutinho, JAP; Freire, MG; Ventura, SPM
2018, BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 46, 4, 390-397.

Valorization of olive tree leaves: Extraction of oleanolic acid using aqueous solutions of surface-active ionic liquids

Claudio, AFM; Cognigni, A; de Faria, ELP; Silvestre, AJD; Zirbs, R; Freire, MG; Bica, K
2018, SEPARATION AND PURIFICATION TECHNOLOGY, 204, 30-37.

Enhanced separation performance of aqueous biphasic systems formed by carbohydrates and tetraalkylphosphonium- or tetraalkylammonium-based ionic liquids

Quental, MV; Pereira, MM; Ferreira, AM; Pedro, SN; Shahriari, S; Mohamadou, A; Coutinho, JAP; Freire, MG
2018, GREEN CHEMISTRY, 20, 13, 2978-2983.

Cholinium-Based Good's Buffers Ionic Liquids as Remarkable Stabilizers and Recyclable Preservation Media for Recombinant Small RNAs

Pedro, AQ; Pereira, P; Quental, MJ; Carvalho, AP; Santos, SM; Queiroz, JA; Sousa, F; Freire, MG
2018, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 6, 12, 16645-16656.

Extraction and recovery processes for cynaropicrin from Cynara cardunculus L. using aqueous solutions of surface-active ionic liquids

de, Faria, ELP; Gomes, MV; Cláudio, AFM; Freire, CSR; Silvestre, AJD; Freire, MG
2018, BIOPHYSICAL REVIEWS, 10, 3, 915-925.

Aqueous two-phase systems formed by maltodextrin and acetonitrile: Phase diagrams and partitioning studies

Souza, IN; Soares, CMF; Souza, RL; Freire, MG; Lima, AS
2018, FLUID PHASE EQUILIBRIA, 476, 179-185.

Pioneering Use of Ionic Liquid-Based Aqueous Biphasic Systems as Membrane-Free Batteries

Navalpotro, P; Neves, CMSS; Palma, J; Freire, MG; Coutinho, JAP; Marcilla, R
2018, ADVANCED SCIENCE, 5, 10.

Glycine-Betaine Ionic Liquid Analogues as Novel Phase-Forming Components of Aqueous Biphasic Systems

Pereira, MM; Almeida, MR; Gomes, J; Rufino, AFCS; Rosa, ME; Coutinho, JAP; Mohamadou, A; Freire, MG
2018, BIOTECHNOLOGY PROGRESS, 34, 5, 1205-1212.

Effective separation of aromatic and aliphatic amino acid mixtures using ionic-liquid-based aqueous biphasic systems

Capela, EV; Quental, MV; Domingues, P; Coutinho, JAP; Freire, MG
2017, GREEN CHEMISTRY, 19, 8, 1850-1854.

Designing the thermal behaviour of aqueous biphasic systems composed of ammonium-based zwitterions

Ferreira, AM; Passos, H; Okafuji, A; Freire, MG; Coutinho, JAP; Ohno, H
2017, GREEN CHEMISTRY, 19, 17, 4012-4016.

Enhanced extraction and biological activity of 7-hydroxymatairesinol obtained from Norway spruce knots using aqueous solutions of ionic liquids

Ferreira, AM; Morais, ES; Leite, AC; Mohamadou, A; Holmbom, B; Holmbom, T; Neves, BM; Coutinho, JAP; Freire, MG; Silvestre, AJD
2017, GREEN CHEMISTRY, 19, 11, 2626-2635.

Switchable (pH-driven) aqueous biphasic systems formed by ionic liquids as integrated production-separation platforms

Ferreira, AM; Claudio, AFM; Valega, M; Domingues, FMJ; Silvestre, AJD; Rogers, RD; Coutinho, JAP; Freire, MG
2017, GREEN CHEMISTRY, 19, 12, 2768-2773.

Solvatochromic parameters of deep eutectic solvents formed by ammonium-based salts and carboxylic acids

Teles, ARR; Capela, EV; Carmo, RS; Coutinho, JAP; Silvestre, AJD; Freire, MG
2017, FLUID PHASE EQUILIBRIA, 448, 15-21.

Good's buffer ionic liquids as relevant phase-forming components of self-buffered aqueous biphasic systems

Taha, M; Quental, MV; Silva, FAE; Capela, EV; Freire, MG; Ventura, SPM; Coutinho, JAP
2017, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 92, 9, 2287-2299.

Alternative probe for the determination of the hydrogen-bond acidity of ionic liquids and their aqueous solutions

Madeira, PP; Passos, H; Gomes, J; Coutinho, JAP; Freire, MG
2017, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 19, 18, 11011-11016.

Improved monitoring of aqueous samples by the preconcentration of active pharmaceutical ingredients using ionic-liquid-based systems

Almeida, HFD; Freire, MG; Marrucho, IM
2017, GREEN CHEMISTRY, 19, 19, 4651-4659.

Removal of Nonsteroidal Anti-Inflammatory Drugs from Aqueous Environments with Reusable Ionic-Liquid-Based Systems

Almeida, HFD; Marrucho, IM; Freire, MG
2017, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 5, 3, 2428-2436.

Aqueous Solutions of Surface-Active Ionic Liquids: Remarkable Alternative Solvents To Improve the Solubility of Triterpenic Acids and Their Extraction from Biomass

de Faria, ELP; Shabudin, SV; Claudio, AFM; Valega, M; Domingues, FMJ; Freire, CSR; Silvestre, AJD; Freire, MG
2017, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 5, 8, 7344-7351.

Temperature dependency of aqueous biphasic systems: an alternative approach for exploring the differences between Coulombic-dominated salts and ionic liquids

Silva, FAE; Pereira, JFB; Kurnia, KA; Ventura, SPM; Silva, AMS; Rogers, RD; Coutinho, JAP; Freire, MG
2017, CHEMICAL COMMUNICATIONS, 53, 53, 7298-7301.
ISBN: 1364-548X

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Ventura, SPM; Silva, FAE; Quental, MV; Mondal, D; Freire, MG; Coutinho, JAP
2017, CHEMICAL REVIEWS, 117, 10, 6984-7052.
ISBN: 1520-6890

A Triple Salting-Out Effect is Required for the Formation of Ionic-Liquid-Based Aqueous Multiphase Systems

Passos, H; Costa, SH; Fernandes, AM; Freire, MG; Rogers, RD; Coutinho, JAP
2017, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 47, 15058-15062.

Long-term protein packaging in cholinium-based ionic liquids: improved catalytic activity and enhanced stability of cytochrome c against multiple stresses

Bisht, M; Mondal, D; Pereira, MM; Freire, MG; Venkatesu, P; Coutinho, JAP
2017, GREEN CHEMISTRY, 19, 20, 4900-4911.

Toward an Understanding of the Mechanisms behind the Formation of Liquid-liquid Systems formed by Two Ionic Liquids

Neves, CMSS; Silva, AMS; Fernandes, AM; Coutinho, JAP; Freire, MG
2017, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 8, 13, 3015-3019.

Deep Eutectic Solvents as Efficient Media for the Extraction and Recovery of Cynaropicrin from Cynara cardunculus L. Leaves

de Faria, ELP; do Carmo, RS; Claudio, AFM; Freire, CSR; Freire, MG; Silvestre, AJD
2017, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18, 11.

Densities, viscosities and derived thermophysical properties of water-saturated imidazolium-based ionic liquids

Martins, MAR; Neves, CMSS; Kurnia, KA; Carvalho, PJ; Rocha, MAA; Santos, LMNBF; Pinho, SP; Freire, MG
2016, FLUID PHASE EQUILIBRIA, 407, 188-196.

Thermoreversible (Ionic-Liquid-Based) Aqueous Biphasic Systems

Passos, H; Luis, A; Coutinho, JAP; Freire, MG
2016, SCIENTIFIC REPORTS, 6.

Suitability of bio-based ionic liquids for the extraction and purification of IgG antibodies

Mondal, D; Sharma, M; Quental, MV; Tavares, APM; Prasad, K; Freire, MG
2016, GREEN CHEMISTRY, 18, 22, 6071-6081.

A critical assessment of the mechanisms governing the formation of aqueous biphasic systems composed of protic ionic liquids and polyethylene glycol

Claudio, AFM; Pereira, JFB; McCrary, PD; Freire, MG; Coutinho, JAP; Rogers, RD
2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 43, 30009-30019.

Alkaloids as Alternative Probes To Characterize the Relative Hydrophobicity of Aqueous Biphasic Systems

Pereira, JFB; Magri, A; Quental, MV; Gonzalez-Miquel, M; Freire, MG; Coutinho, JAP
2016, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 4, 3, 1512-1520.

Aqueous biphasic systems composed of ionic liquids and polypropylene glycol: insights into their liquid-liquid demixing mechanisms

Neves, CMSS; Shahriari, S; Lemus, J; Pereira, JFB; Freire, MG; Coutinho, JAP
2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 30, 20571-20582.

Are Aqueous Biphasic Systems Composed of Deep Eutectic Solvents Ternary or Quaternary Systems?

Passos, H; Tavares, DJP; Ferreira, AM; Freire, MG; Coutinho, JAP
2016, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 4, 5, 2881-2886.

Densities and Viscosities of Mixtures of Two Ionic Liquids Containing a Common Cation

Almeida, HFD; Lopes, JNC; Rebelo, LPN; Coutinho, JAP; Freire, MG; Marrucho, IM
2016, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 61, 8, 2828-2843.

Enhanced tunability afforded by aqueous biphasic systems formed by fluorinated ionic liquids and carbohydrates

Ferreira, AM; Esteves, PDO; Boal-Palheiros, I; Pereiro, AB; Rebelo, LPN; Freire, MG
2016, GREEN CHEMISTRY, 18, 4, 1070-1079.

Fluorination effects on the thermodynamic, thermophysical and surface properties of ionic liquids

Vieira, NSM; Luis, A; Reis, PM; Carvalho, PJ; Lopes-da-Silva, JA; Esperanca, JMSS; Araujo, JMM; Rebelo, LPN; Freire, MG; Pereiro, AB
2016, JOURNAL OF CHEMICAL THERMODYNAMICS, 97, 354-361.

Improved extraction of fluoroquinolones with recyclable ionic-liquid-based aqueous biphasic systems

Almeida, HFD; Freire, MG; Marrucho, IM
2016, GREEN CHEMISTRY, 18, 9, 2717-2725.

Improving the extraction and purification of immunoglobulin G by the use of ionic liquids as adjuvants in aqueous biphasic systems

Ferreira, AM; Faustino, VFM; Mondal, D; Coutinho, JAP; Freire, MG
2016, JOURNAL OF BIOTECHNOLOGY, 236, 166-175.

Influence of Nanosegregation on the Surface Tension of Fluorinated Ionic Liquids

Luis, A; Shimizu, K; Araujo, JMM; Carvalho, PJ; Lopes-da-Silva, JA; Lopes, JNC; Rebelo, LPN; Coutinho, JAP; Freire, MG; Pereiro, AB
2016, LANGMUIR, 32, 24, 6130-6139.

Ionic liquids in chromatographic and electrophoretic techniques: toward additional improvements in the separation of natural compounds

Soares, B; Passos, H; Freire, CSR; Coutinho, JAP; Silvestre, AJD; Freire, MG
2016, GREEN CHEMISTRY, 18, 17, 4582-4604.

Single-step purification of ovalbumin from egg white using aqueous biphasic systems

Pereira, MM; Cruz, RAP; Almeida, MR; Lima, AS; Coutinho, JAP; Freire, MG
2016, PROCESS BIOCHEMISTRY, 51, 6, 781-791.

Solid-liquid equilibria of binary mixtures of fluorinated ionic liquids

Teles, ARR; Correia, H; Maximo, GJ; Rebelo, LPN; Freire, MG; Pereiro, AB; Coutinhoa, JAP
2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 36, 25741-25750.

Surface tensions of ionic liquids: Non-regular trend along the number of cyano groups

Almeida, HFD; Carvalho, PJ; Kurnia, KA; Lopes-da-Silva, JA; Coutinho, JAP; Freire, MG
2016, FLUID PHASE EQUILIBRIA, 409, 458-465.

The effect of n vs. iso isomerization on the thermophysical properties of aromatic and non-aromatic ionic liquids

Rodrigues, ASMC; Almeida, HFD; Freire, MG; Lopes-da-Silva, JA; Coutinho, JAP; Santos, LMNBF
2016, FLUID PHASE EQUILIBRIA, 423, 190-202.

Why are some cyano-based ionic liquids better glucose solvents than water?

Batista, MLS; Passos, H; Henriques, BJM; Maginn, EJ; Pinho, SP; Freire, MG; Gomes, JRB; Coutinho, JAP
2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 28, 18958-18970.

Solubility and solvation of monosaccharides in ionic liquids

Teles, ARR; Dinis, TBV; Capela, EV; Santos, LMNBF; Pinho, SP; Freire, MG; Coutinho, JAP
2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 29, 19722-19730.

One-step extraction and concentration of estrogens for an adequate monitoring of wastewater using ionic-liquid-based aqueous biphasic systems

Dinis, TBV; Passos, H; Lima, DLD; Esteves, VI; Coutinho, JAP; Freire, MG
2015, GREEN CHEMISTRY, 17, 4, 2570-2579.

Thermophysical Properties of Two Ammonium-Based Protic Ionic Liquids

Bhattacharjee, A; Coutinho, JAP; Freire, MG; Carvalho, PJ
2015, JOURNAL OF SOLUTION CHEMISTRY, 44, 03-Apr, 703-717.

Novel Biocompatible and Self-buffering Ionic Liquids for Biopharmaceutical Applications

Taha, M; Almeida, MR; Silva, FAE; Domingues, P; Ventura, SPM; Coutinho, JAP; Freire, MG
2015, CHEMISTRY-A EUROPEAN JOURNAL, 21, 12, 4781-4788.

Enhancing the Antioxidant Characteristics of Phenolic Acids by Their Conversion into Cholinium Salts

Sintra, TE; Luis, A; Rocha, SN; Ferreira, AIMCL; Goncalves, F; Santos, LMNBF; Neves, BM; Freire, MG; Ventura, SPM; Coutinho, JAP
2015, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 3, 10, 2558-2565.

Contact angles and wettability of ionic liquids on polar and non-polar surfaces

Pereira, MM; Kurnia, KA; Sousa, FL; Silva, NJO; Lopes-da-Silva, JA; Coutinhoa, JAP; Freire, MG
2015, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17, 47, 31653-31661.

Aqueous Biphasic Systems Composed of Ionic Liquids and Acetate-Based Salts: Phase Diagrams, Densities, and Viscosities

Quental, MV; Passos, H; Kurnia, KA; Coutinho, JAP; Freire, MG
2015, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 60, 6, 1674-1682.

Enhanced extraction of proteins using cholinium-based ionic liquids as phase-forming components of aqueous biphasic systems

Quental, MV; Caban, M; Pereira, MM; Stepnowski, P; Coutinho, JAP; Freire, MG
2015, BIOTECHNOLOGY JOURNAL, 10, 9, 1457-1466.

Controlling the Formation of Ionic-Liquid-based Aqueous Biphasic Systems by Changing the Hydrogen-Bonding Ability of Polyethylene Glycol End Groups

Pereira, JFB; Kurnia, KA; Freire, MG; Coutinho, JAP; Rogers, RD
2015, CHEMPHYSCHEM, 16, 10, 2219-2225.

Effect of salts on the solubility of ionic liquids in water: experimental and electrolyte Perturbed-Chain Statistical Associating Fluid Theory

Neves, CMSS; Held, C; Mohammad, S; Schleinitz, M; Coutinho, JAP; Freire, MG
2015, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17, 47, 32044-32052.

Comprehensive study on the impact of the cation alkyl side chain length on the solubility of water in ionic liquids

Kurnia, KA; Neves, CMSS; Freire, MG; Santos, LMNBF; Coutinho, JAP
2015, JOURNAL OF MOLECULAR LIQUIDS, 210, 264-271.

Mutual solubilities between water and non-aromatic sulfonium-, ammonium- and phosphonium-hydrophobic ionic liquids

Kurnia, KA; Quental, MV; Santos, LMNBF; Freire, MG; Coutinho, JAP
2015, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17, 6, 4569-4577.

Enhanced extraction of bovine serum albumin with aqueous biphasic systems of phosphonium- and ammonium-based ionic liquids

Pereira, MM; Pedro, SN; Quental, MV; Lima, AS; Coutinho, JAP; Freire, MG
2015, JOURNAL OF BIOTECHNOLOGY, 206, 17-25.

Extraction and stability of bovine serum albumin (BSA) using cholinium-based Good's buffers ionic liquids

Taha, M; Quental, MV; Correia, I; Freire, MG; Coutinho, JAP
2015, PROCESS BIOCHEMISTRY, 50, 7, 1158-1166.

Thermophysical properties of phosphonium-based ionic liquids

Bhattacharjee, A; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP; Carvalho, PJ
2015, FLUID PHASE EQUILIBRIA, 400, 103-113.

The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes

Claudio, AFM; Neves, MC; Shimizu, K; Lopes, JNC; Freire, MG; Coutinho, JAP
2015, GREEN CHEMISTRY, 17, 7, 3948-3963.

Hydrogen-bond acidity of ionic liquids: an extended scale

Kurnia, KA; Lima, F; Claudio, AFM; Coutinho, JAP; Freire, MG
2015, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17, 29, 18980-18990.

Effect of the Methylation and N-H Acidic Group on the Physicochemical Properties of Imidazolium-Based Ionic Liquids

Rodrigues, ASMC; Rocha, MAA; Almeida, HFD; Neves, CMSS; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP; Santos, LMNBF
2015, JOURNAL OF PHYSICAL CHEMISTRY B, 119, 28, 8781-8792.

Good's buffers as novel phase-forming components of ionic-liquid-based aqueous biphasic systems

Luis, A; Dinis, TBV; Passos, H; Taha, M; Freire, MG
2015, BIOCHEMICAL ENGINEERING JOURNAL, 101, 142-149.

Poly(vinyl alcohol) as a novel constituent to form aqueous two-phase systems with acetonitrile: Phase diagrams and partitioning experiments

Cardoso, GD; Souza, IN; Pereira, MM; Costa, LP; Freire, MG; Soares, CMF; Lima, AS
2015, CHEMICAL ENGINEERING RESEARCH & DESIGN, 94, 317-323.

Extração e Purificação de Produtos de Valor Acrescentado Utilizando Sistemas Aquosos Bifásicos Constituídos por Líquidos Iónicos

Ferreira, AM; Freire, MG
2015, Química - Boletim da SPQ, 139, 23-34.

Vapor-Liquid Equilibria of Water plus Alkylimidazolium-Based Ionic Liquids: Measurements and Perturbed-Chain Statistical Associating Fluid Theory Modeling

Passos, H; Khan, I; Mutelet, F; Oliveira, MB; Carvalho, PJ; Santos, LMNBF; Held, C; Sadowski, G; Freire, MG; Coutinho, JAP
2014, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 53, 9, 3737-3748.

Ionic liquids as additives to enhance the extraction of antioxidants in aqueous two-phase systems

Almeida, MR; Passos, H; Pereira, MM; Lima, AS; Coutinho, JAP; Freire, MG
2014, SEPARATION AND PURIFICATION TECHNOLOGY, 128, 1-10.

Ionic liquid solutions as extractive solvents for value-added compounds from biomass

Passos, H; Freire, MG; Coutinho, JAP
2014, GREEN CHEMISTRY, 16, 12, 4786-4815.

Thermophysical properties of sulfonium- and ammonium-based ionic liquids

Bhattacharjee, A; Luis, A; Santos, JH; Lopes-da-Silva, JA; Freire, MG; Carvalho, PJ; Coutinho, JAP
2014, FLUID PHASE EQUILIBRIA, 381, 36-45.

Cation Alkyl Side Chain Length and Symmetry Effects on the Surface Tension of Ionic Liquids

Almeida, HFD; Freire, MG; Fernandes, AM; Lopes-da-Silva, JA; Morgado, P; Shimizu, K; Filipe, EJM; Lopes, JNC; Santos, LMNBF; Coutinho, JAP
2014, LANGMUIR, 30, 22, 6408-6418.

Novel aqueous two-phase systems composed of acetonitrile and polyols: Phase diagrams and extractive performance

Cardoso, GD; Souza, IN; Mourao, T; Freire, MG; Soares, CMF; Lima, AS
2014, SEPARATION AND PURIFICATION TECHNOLOGY, 124, 54-60.

Aqueous two-phase systems formed by biocompatible and biodegradable polysaccharides and acetonitrile

Cardoso, GDB; Souz, IN; Pereira, MM; Freire, MG; Soares, CMF; Lima, AS
2014, SEPARATION AND PURIFICATION TECHNOLOGY, 136, 74-80.

Development of back-extraction and recyclability routes for ionic-liquid-based aqueous two-phase systems

Claudio, AFM; Marques, CFC; Boal-Palheiros, I; Freire, MG; Coutinho, JAP
2014, GREEN CHEMISTRY, 16, 1, 259-268.

Extended scale for the hydrogen-bond basicity of ionic liquids

Claudio, AFM; Swift, L; Hallett, JP; Welton, T; Coutinho, JAP; Freire, MG
2014, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16, 14, 6593-6601.

Inclusion Complexes of Ionic Liquids and Cyclodextrins: Are They Formed in the Gas Phase?

Fernandes, AM; Schroder, B; Barata, T; Freire, MG; Coutinho, JAP
2014, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25, 5, 852-860.

Complete removal of textile dyes from aqueous media using ionic-liquid-based aqueous two-phase systems

Ferreira, AM; Coutinho, JAP; Fernandes, AM; Freire, MG
2014, SEPARATION AND PURIFICATION TECHNOLOGY, 128, 58-66.

Ionic liquids for thiols desulfurization: Experimental liquid-liquid equilibrium and COSMO-RS description

Ferreira, AR; Freire, MG; Ribeiro, JC; Lopes, FM; Crespo, JG; Coutinho, JAP
2014, FUEL, 128, 314-329.

Effect of Polyvalent Ions in the Formation of Ionic-Liquid-Based Aqueous Biphasic Systems

Kurnia, KA; Freire, MG; Coutinho, JAP
2014, JOURNAL OF PHYSICAL CHEMISTRY B, 118, 1, 297-308.

The effect of the cation alkyl chain branching on mutual solubilities with water and toxicities

Kurnia, KA; Sintra, TE; Neves, CMSS; Shimizu, K; Lopes, JNC; Goncalves, F; Ventura, SPM; Freire, MG; Santos, LMNBF; Coutinho, JAP
2014, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16, 37, 19952-19963.

Impact of the cation symmetry on the mutual solubilities between water and imidazolium-based ionic liquids

Martins, MAR; Neves, CMSS; Kurnia, KA; Luis, A; Santos, LMNBF; Freire, MG; Pinho, SP; Coutinho, JAP
2014, FLUID PHASE EQUILIBRIA, 375, 161-167.

Analysis of the isomerism effect on the mutual solubilities of bis(trifluoromethylsulfonyl)imide-based ionic liquids with water

Martins, MAR; Neves, CMSS; Kurnia, KA; Santos, LMNBF; Freire, MG; Pinho, SP; Coutinho, JAP
2014, FLUID PHASE EQUILIBRIA, 381, 28-35.

Generating Ionic Liquids from Ionic Solids: An Investigation of the Melting Behavior of Binary Mixtures of Ionic Liquids

Maximo, GJ; Santos, RJBN; Brandao, P; Esperanca, JMSS; Costa, MC; Meirelles, AJA; Freire, MG; Coutinho, JAP
2014, CRYSTAL GROWTH & DESIGN, 14, 9, 4270-4277.

The impact of ionic liquid fluorinated moieties on their thermophysical properties and aqueous phase behaviour

Neves, CMSS; Kurnia, KA; Shimizu, K; Marrucho, IM; Rebelo, LPN; Coutinho, JAP; Freire, MG; Lopes, JNC
2014, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16, 39, 21340-21348.

Enhancing the adsorption of ionic liquids onto activated carbon by the addition of inorganic salts

Neves, CMSS; Lemus, J; Freire, MG; Palomar, J; Coutinho, JAP
2014, CHEMICAL ENGINEERING JOURNAL, 252, 305-310.

Surface tensions of binary mixtures of ionic liquids with bis(trifluoromethylsulfonyl)imide as the common anion (vol 64, pg 22, 2013)

Oliveira, MB; Dominguez-Perez, M; Cabeza, O; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP
2014, JOURNAL OF CHEMICAL THERMODYNAMICS, 78, 284-284.

Molecular interactions in aqueous biphasic systems composed of polyethylene glycol and crystalline vs. liquid cholinium-based salts

Pereira, JFB; Kurnia, KA; Cojocaru, OA; Gurau, G; Rebelo, LPN; Rogers, RD; Freire, MG; Coutinho, JAP
2014, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16, 12, 5723-5731.

Extraction and Recovery of Rutin from Acerola Waste using Alcohol-Salt-Based Aqueous Two-Phase Systems

Reis, IAO; Santos, SB; Pereira, FDS; Sobral, CRS; Freire, MG; Freitas, LS; Soares, CMF; Lima, AS
2014, SEPARATION SCIENCE AND TECHNOLOGY, 49, 5, 656-663.

Good's buffers as a basis for developing self-buffering and biocompatible ionic liquids for biological research

Taha, M; Silva, FAE; Quental, MV; Ventura, SPM; Freire, MG; Coutinho, JAP
2014, GREEN CHEMISTRY, 16, 6, 3149-3159.

Evidence for the Interactions Occurring Between Ionic Liquids and Tetraethylene Glycol in Binary Mixtures and Aqueous Biphasic Systems

Tome, LIN; Pereira, JFB; Rogers, RD; Freire, MG; Gomes, JRB; Coutinho, JAP
2014, JOURNAL OF PHYSICAL CHEMISTRY B, 118, 17, 4615-4629.

"Washing-out" ionic liquids from polyethylene glycol to form aqueous biphasic systems

Tome, LIN; Pereira, JFB; Rogers, RD; Freire, MG; Gomes, JRB; Coutinho, JAP
2014, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16, 6, 2271-2274.

Surface tension and refractive index of pure and water-saturated tetradecyltrihexylphosphonium-based ionic liquids

Almeida, HFD; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP
2013, JOURNAL OF CHEMICAL THERMODYNAMICS, 57, 372-379.

Aqueous biphasic systems: a benign route using cholinium-based ionic liquids

Shahriari, S; Tome, LC; Araujo, JMM; Rebelo, LPN; Coutinho, JAP; Marrucho, IM; Freire, MG
2013, RSC ADVANCES, 3, 6, 1835-1843.

The impact of self-aggregation on the extraction of biomolecules in ionic-liquid-based aqueous two-phase systems

Passos, H; Trindade, MP; Vaz, TSM; da Costa, LP; Freire, MG; Coutinho, JAP
2013, SEPARATION AND PURIFICATION TECHNOLOGY, 108, 174-180.

Aqueous two-phase systems based on acetonitrile and carbohydrates and their application to the extraction of vanillin

Cardoso, GD; Mourao, T; Pereira, FM; Freire, MG; Fricks, AT; Soares, CMF; Lima, AS
2013, SEPARATION AND PURIFICATION TECHNOLOGY, 104, 106-113.

Extraction of tetracycline from fermentation broth using aqueous two-phase systems composed of polyethylene glycol and cholinium-based salts

Pereira, JFB; Vicente, F; Santos-Ebinuma, VC; Araujo, JM; Pessoa, A; Freire, MG; Coutinho, JAP
2013, PROCESS BIOCHEMISTRY, 48, 4, 716-722.

Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

Marques, CFC; Mourao, T; Neves, CMSS; Lima, AS; Boal-Palheiros, I; Coutinho, JAP; Freire, MG
2013, BIOTECHNOLOGY PROGRESS, 29, 3, 645-654.

Aqueous biphasic systems composed of ionic liquids and polymers: A platform for the purification of biomolecules

Pereira, JFB; Ventura, SPM; Silva, FAE; Shahriari, S; Freire, MG; Coutinho, JAP
2013, SEPARATION AND PURIFICATION TECHNOLOGY, 113, 83-89.

Enhanced extraction of caffeine from guarana seeds using aqueous solutions of ionic liquids

Claudio, AFM; Ferreira, AM; Freire, MG; Coutinho, JAP
2013, GREEN CHEMISTRY, 15, 7, 2002-2010.

Surface tensions of binary mixtures of ionic liquids with bis(trifluoromethylsulfonyl) imide as the common anion

Oliveira, MB; Dominguez-Perez, M; Cabeza, O; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP
2013, JOURNAL OF CHEMICAL THERMODYNAMICS, 64, 22-27.

Combining ionic liquids and polyethylene glycols to boost the hydrophobic-hydrophilic range of aqueous biphasic systems

Pereira, JFB; Rebelo, LPN; Rogers, RD; Coutinho, JAP; Freire, MG
2013, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 15, 45, 19580-19583.

Systematic Study of the Thermophysical Properties of Imidazolium-Based Ionic Liquids with Cyano-Functionalized Anions

Neves, CMSS; Kurnia, KA; Coutinho, JAP; Marrucho, IM; Lopes, JNC; Freire, MG; Rebelo, LPN
2013, JOURNAL OF PHYSICAL CHEMISTRY B, 117, 35, 10271-10283.

Alkylimidazolium Based Ionic Liquids: Impact of Cation Symmetry on Their Nanoscale Structural Organization

Rocha, MAA; Neves, CMSS; Freire, MG; Russina, O; Triolo, A; Coutinho, JAP; Santos, LMNBF
2013, JOURNAL OF PHYSICAL CHEMISTRY B, 117, 37, 10889-10897.

Solubility of non-aromatic hexafluorophosphate-based salts and ionic liquids in water determined by electrical conductivity

Neves, CMSS; Rodrigues, AR; Kurnia, KA; Esperanca, JMSS; Freire, MG; Coutinho, JAP
2013, FLUID PHASE EQUILIBRIA, 358, 50-55.

Composition and structural effects on the adsorption of ionic liquids onto activated carbon

Lemus, J; Neves, CMSS; Marques, CFC; Freire, MG; Coutinho, JAP; Palomar, J
2013, ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 15, 9, 1752-1759.

Insight into the Interactions That Control the Phase Behaviour of New Aqueous Biphasic Systems Composed of Polyethylene Glycol Polymers and Ionic Liquids

Freire, MG; Pereira, JFB; Francisco, M; Rodriguez, H; Rebelo, LPN; Rogers, RD; Coutinho, JAP
2012, CHEMISTRY-A EUROPEAN JOURNAL, 18, 6, 1831-1839.

Characterization of aqueous biphasic systems composed of ionic liquids and a citrate-based biodegradable salt

Passos, H; Ferreira, AR; Claudio, AFM; Coutinho, JAP; Freire, MG
2012, BIOCHEMICAL ENGINEERING JOURNAL, 67, 68-76.

Density and Viscosity Data for Binary Mixtures of 1-Alkyl-3-methylimidazolium Alkylsulfates plus Water

Bhattacharjee, A; Varanda, C; Freire, MG; Matted, S; Santos, LMNBF; Marrucho, IM; Coutinho, JAP
2012, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 57, 12, 3473-3482.

Increased significance of food wastes: Selective recovery of added-value compounds

Reis, IAO; Santos, SB; Santos, LA; Oliveira, N; Freire, MG; Pereira, JFB; Ventura, SPM; Coutinho, JAP; Soares, CMF; Lima, AS
2012, FOOD CHEMISTRY, 135, 4, 2453-2461.

Influence of the anion on the surface tension of 1-ethyl-3-methylimidazolium-based ionic liquids

Almeida, HFD; Teles, ARR; Lopes-da-Silva, JA; Freire, MG; Coutinho, JAP
2012, JOURNAL OF CHEMICAL THERMODYNAMICS, 54, 49-54.

Evaluation of the impact of phosphate salts on the formation of ionic-liquid-based aqueous biphasic systems

Mourao, T; Claudio, AFM; Boal-Palheiros, I; Freire, MG; Coutinho, JAP
2012, JOURNAL OF CHEMICAL THERMODYNAMICS, 54, 398-405.

Optimization of the gallic acid extraction using ionic-liquid-based aqueous two-phase systems

Claudio, AFM; Ferreira, AM; Freire, CSR; Silvestre, AJD; Freire, MG; Coutinho, JAP
2012, SEPARATION AND PURIFICATION TECHNOLOGY, 97, 142-149.

Overview of the Liquid-Liquid Equilibria of Ternary Systems Composed of Ionic Liquid and Aromatic and Aliphatic Hydrocarbons, and Their Modeling by COSMO-RS

Ferreira, AR; Freire, MG; Ribeiro, JC; Lopes, FM; Crespo, JG; Coutinho, JAP
2012, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 51, 8, 3483-3507.

Ionic-Liquid-Based Aqueous Biphasic Systems with Controlled pH: The Ionic Liquid Anion Effect

Ventura, SPM; Sousa, SG; Serafim, LS; Lima, AS; Freire, MG; Coutinho, JAP
2012, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 57, 2, 507-512.

Thermophysical Properties of Five Acetate-Based Ionic Liquids

Almeida, HFD; Passos, H; Lopes-da-Silva, JA; Fernandes, AM; Freire, MG; Coutinho, JAP
2012, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 57, 11, 3005-3013.

Impact of Self-Aggregation on the Formation of Ionic-Liquid-Based Aqueous Biphasic Systems

Freire, MG; Neves, CMSS; Lopes, JNC; Marrucho, IM; Coutinho, JAP; Rebelo, LPN
2012, JOURNAL OF PHYSICAL CHEMISTRY B, 116, 26, 7660-7668.

Role of the Hofmeister Series in the Formation of Ionic-Liquid-Based Aqueous Biphasic Systems

Shahriari, S; Neves, CMSS; Freire, MG; Coutinho, JAP
2012, JOURNAL OF PHYSICAL CHEMISTRY B, 116, 24, 7252-7258.

Surface Tension of Binary Mixtures of 1-Alkyl-3-methylimidazolium Bis(trifluoromethylsulfonyl)imide Ionic Liquids: Experimental Measurements and Soft-SAFT Modeling

Oliveira, MB; Dominguez-Perez, M; Freire, MG; Llovell, F; Cabeza, O; Lopes-da-Silva, JA; Vega, LF; Coutinho, JAP
2012, JOURNAL OF PHYSICAL CHEMISTRY B, 116, 40, 12133-12141.

Surface tension of ionic liquids and ionic liquid solutions

Tariq, M; Freire, MG; Saramago, B; Coutinho, JAP; Lopes, JNC; Rebelo, LPN
2012, CHEMICAL SOCIETY REVIEWS, 41, 2, 829-868.

Ionic-liquid-based aqueous biphasic systems for improved detection of bisphenol A in human fluids

Passos, H; Sousa, ACA; Pastorinho, MR; Nogueira, AJA; Rebelo, LPN; Coutinho, JAP; Freire, MG
2012, ANALYTICAL METHODS, 4, 9, 2664-2667.

Aqueous biphasic systems: a boost brought about by using ionic liquids

Freire, MG; Claudio, AFM; Araujo, JMM; Coutinho, JAP; Marrucho, IM; Lopes, JNC; Rebelo, LPN
2012, CHEMICAL SOCIETY REVIEWS, 41, 14, 4966-4995.

Improved recovery of ionic liquids from contaminated aqueous streams using aluminium-based salts

Neves, CMSS; Freire, MG; Coutinho, JAP
2012, RSC ADVANCES, 2, 29, 10882-10890.

Partition Coefficients of Alkaloids in Biphasic Ionic-Liquid-Aqueous Systems and their Dependence on the Hofmeister Series

Freire, MG; Teles, ARR; Lopes, JNC; Rebelo, LPN; Marrucho, IM; Coutinho, JAP
2012, SEPARATION SCIENCE AND TECHNOLOGY, 47, 2, 284-291.

Aqueous solubility, effects of salts on aqueous solubility, and partitioning behavior of hexafluorobenzene: Experimental results and COSMO-RS predictions

Schroder, B; Freire, MG; Varanda, FR; Marrucho, IM; Santos, LMNBF; Coutinho, JAP
2011, CHEMOSPHERE, 84, 4, 415-422.

Design of ionic liquids for lipase purification

Ventura, SPM; Sousa, SG; Freire, MG; Serafim, LS; Lima, AS; Coutinho, JAP
2011, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 879, 26, 2679-2687.

Thermophysical properties of pure and water-saturated tetradecyltrihexylphosphonium-based ionic liquids

Neves, CMSS; Carvalho, PJ; Freire, MG; Coutinho, JAP
2011, JOURNAL OF CHEMICAL THERMODYNAMICS, 43, 6, 948-957.

An Overview of the Liquid-Liquid Equilibria of (Ionic Liquid plus Hydrocarbon) Binary Systems and Their Modeling by the Conductor-like Screening Model for Real Solvents

Ferreira, AR; Freire, MG; Ribeiro, JC; Lopes, FM; Crespo, JG; Coutinho, JAP
2011, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 50, 9, 5279-5294.

Ionic Liquid Based Aqueous Biphasic Systems with Controlled pH: The Ionic Liquid Cation Effect

Ventura, SPM; Sousa, SG; Serafim, LS; Lima, AS; Freire, MG; Coutinho, JAP
2011, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 56, 11, 4253-4260.

Thermophysical Characterization of Ionic Liquids Able To Dissolve Biomass

Freire, MG; Teles, ARR; Rocha, MAA; Schroder, B; Neves, CMSS; Carvalho, PJ; Evtuguin, DV; Santos, LMNBF; Coutinho, JAP
2011, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 56, 12, 4813-4822.

Evaluation of Cation-Anion Interaction Strength in Ionic Liquids

Fernandes, AM; Rocha, MAA; Freire, MG; Marrucho, IM; Coutinho, JAP; Santos, LMNBF
2011, JOURNAL OF PHYSICAL CHEMISTRY B, 115, 14, 4033-4041.

Critical Assessment of the Formation of Ionic-Liquid-Based Aqueous Two-Phase Systems in Acidic Media

Claudio, AFM; Ferreira, AM; Shahriari, S; Freire, MG; Coutinho, JAP
2011, JOURNAL OF PHYSICAL CHEMISTRY B, 115, 38, 11145-11153.

Separation of ethanol-water mixtures by liquid-liquid extraction using phosphonium-based ionic liquids

Neves, CMSS; Granjo, JFO; Freire, MG; Robertson, A; Oliveira, NMC; Coutinho, JAP
2011, GREEN CHEMISTRY, 13, 6, 1517-1526.

Aqueous biphasic systems composed of a water-stable ionic liquid plus carbohydrates and their applications

Freire, MG; Louros, CLS; Rebelo, LPN; Coutinho, JAP
2011, GREEN CHEMISTRY, 13, 6, 1536-1545.

Surface hydrophobization of bacterial and vegetable cellulose fibers using ionic liquids as solvent media and catalysts

Tome, LC; Freire, MG; Rebelo, LPN; Silvestre, AJD; Neto, CP; Marrucho, IM; Freire, CSR
2011, GREEN CHEMISTRY, 13, 9, 2464-2470.

Electrospun nanosized cellulose fibers using ionic liquids at room temperature

Freire, MG; Teles, ARR; Ferreira, RAS; Carlos, LD; Lopes-da-Silva, JA; Coutinho, JAP
2011, GREEN CHEMISTRY, 13, 11, 3173-3180.

Extraction of vanillin using ionic-liquid-based aqueous two-phase systems

Claudio, AFM; Freire, MG; Freire, CSR; Silvestre, AJD; Coutinho, JAP
2010, SEPARATION AND PURIFICATION TECHNOLOGY, 75, 1, 39-47.

Separation of ethanol from water using phosphonium-based ionic liquids

Neves, CMSS; Freire, MG; Coutinho, JAP
2010, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 240.

Partitioning of fluoroquinolones in water/room temperature ionic liquid systems

Araujo, JMM; Freire, MG; Coutinho, JAP; Rebelo, LPN; Marrucho, IM
2010, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 239.

Solubility of non-aromatic ionic liquids in water and correlation using a QSPR approach

Freire, MG; Neves, CMSS; Ventura, SPM; Pratas, MJ; Marrucho, IM; Oliveira, J; Coutinho, JAP; Fernandes, AM
2010, FLUID PHASE EQUILIBRIA, 294, 1-2, 234-240.

Solubility of water in fluorocarbons: Experimental and COSMO-RS prediction results

Freire, MG; Carvalho, PJ; Santos, LMNBF; Gomes, LR; Marrucho, IM; Coutinho, JAP
2010, JOURNAL OF CHEMICAL THERMODYNAMICS, 42, 2, 213-219.

(Extraction of biomolecules using) aqueous biphasic systems formed by ionic liquids and aminoacids

Dominguez-Perez, M; Tome, LIN; Freire, MG; Marrucho, IM; Cabeza, O; Coutinho, JAP
2010, SEPARATION AND PURIFICATION TECHNOLOGY, 72, 1, 85-91.

Tryptophan extraction using hydrophobic ionic liquids

Tome, LIN; Catambas, VR; Teles, ARR; Freire, MG; Marrucho, IM; Coutinho, JAP
2010, SEPARATION AND PURIFICATION TECHNOLOGY, 72, 2, 167-173.

Structural and Positional Isomerism Influence in the Physical Properties of Pyridinium NTf2-Based Ionic Liquids: Pure and Water-Saturated Mixtures

Oliveira, FS; Freire, MC; Carvalho, PI; Coutinho, JAP; Lopes, JNC; Rebelo, LPN; Marrucho, IM
2010, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 55, 10, 4514-4520.

Thermophysical Properties and Water Saturation of [PF6]-Based Ionic Liquids

Neves, CMSS; Batista, MLS; Claudio, AFM; Santos, LMNBF; Marrucho, IM; Freire, MG; Coutinho, JAP
2010, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 55, 11, 5065-5073.

Solubility of Adamantane in Phosphonium-Based Ionic Liquids

Oliveira, FS; Freire, MG; Pratas, MJ; Pauly, J; Daridon, JL; Marrucho, IM; Coutinho, JAP
2010, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 55, 2, 662-665.

Mutual Solubility of Water and Structural/Positional Isomers of N-Alkylpyridinium-Based Ionic Liquids

Freire, MG; Neves, CMSS; Shimizu, K; Bernardes, CES; Marrucho, IM; Coutinho, JAP; Lopes, JNC; Rebelo, LPN
2010, JOURNAL OF PHYSICAL CHEMISTRY B, 114, 48, 15925-15934.

Hydrolysis of Tetrafluoroborate and Hexafluorophosphate Counter Ions in Imidazolium-Based Ionic Liquids

Freire, MG; Neves, CMSS; Marrucho, IM; Coutinho, JAP; Fernandes, AM
2010, JOURNAL OF PHYSICAL CHEMISTRY A, 114, 11, 3744-3749.

H-1 NMR and Molecular Dynamics Evidence for an Unexpected Interaction on the Origin of Salting-In/Salting-Out Phenomena

Freire, MG; Neves, CMSS; Silva, AMS; Santos, LMNBF; Marrucho, IM; Rebelo, LPN; Shah, JK; Maginn, EJ; Coutinho, JAP
2010, JOURNAL OF PHYSICAL CHEMISTRY B, 114, 5, 2004-2014.

Ionic liquids as adjuvants for the tailored extraction of biomolecules in aqueous biphasic systems

Pereira, JFB; Lima, AS; Freire, MG; Coutinho, JAP
2010, GREEN CHEMISTRY, 12, 9, 1661-1669.

High-performance extraction of alkaloids using aqueous two-phase systems with ionic liquids

Freire, MG; Neves, CMSS; Marrucho, IM; Lopes, JNC; Rebelo, LPN; Coutinho, JAP
2010, GREEN CHEMISTRY, 12, 10, 1715-1718.

Extraction of Biomolecules Using Phosphonium-Based Ionic Liquids + K3PO4 Aqueous Biphasic Systems

Louros, CLS; Claudio, AFM; Neves, CMSS; Freire, MG; Marrucho, IM; Pauly, J; Coutinho, JAP
2010, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 11, 4, 1777-1791.

Ion Specific Effects on the Mutual Solubilities of Water and Hydrophobic Ionic Liquids

Freire, MG; Carvalho, PJ; Silva, AMS; Santos, LMNBF; Rebelo, LPN; Marrucho, IM; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 1, 202-211.

Towards an Understanding of the Mutual Solubilities of Water and Hydrophobic Ionic Liquids in the Presence of Salts: The Anion Effect

Tome, LIN; Varanda, FR; Freire, MG; Marrucho, IM; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 9, 2815-2825.

Evaluation of Cation Influence on the Formation and Extraction Capability of Ionic-Liquid-Based Aqueous Biphasic Systems

Neves, CMSS; Ventura, SPM; Freire, MG; Marrucho, IM; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 15, 5194-5199.

Evaluation of Anion Influence on the Formation and Extraction Capacity of Ionic-Liquid-Based Aqueous Biphasic Systems

Ventura, SPM; Neves, CMSS; Freire, MG; Marrucho, IM; Oliveira, J; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 27, 9304-9310.

On the Interactions between Amino Acids and Ionic Liquids in Aqueous Media

Tome, LIN; Dominguez-Perez, M; Claudio, AFM; Freire, MG; Marrucho, IM; Cabeza, O; Coutinho, JAP
2009, JOURNAL OF PHYSICAL CHEMISTRY B, 113, 42, 13971-13979.

I&EC 121-Specific interactions between salts and ionic liquids in aqueous salt solutions

Tome, LIN; Varanda, FR; Freire, MG; Marrucho, IM; Coutinho, JAP
2008, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 236.

Optimization of oxygen mass transfer in a multiphase bioreactor with perfluorodecalin as a second liquid phase

Amaral, PFF; Freire, MG; Rocha-Leao, MHM; Marrucho, IM; Coutinho, JAP; Coelho, MAZ
2008, BIOTECHNOLOGY AND BIOENGINEERING, 99, 3, 588-598.

Aging mechanisms of oil-in-water emulsions based on a bioemulsifier produced by Yarrowia lipolytica

Trindade, JR; Freire, MG; Amaral, PFF; Coelho, MAZ; Coutinho, JAP; Marrucho, IM
2008, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 324, 1-3, 149-154.

Evaluation of COSMO-RS for the prediction of LLE and VLE of water and ionic liquids binary systems

Freire, MG; Ventura, SPM; Santos, LMNBF; Marrucho, IM; Coutinho, JAP
2008, FLUID PHASE EQUILIBRIA, 268, 1-2, 74-84.

Viscosities of liquid fluorocompounds

Freire, MG; Ferreira, AGM; Fonseca, IMA; Marrucho, IM; Coutinho, JAP
2008, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 53, 2, 538-542.

Densities and derived thermodynamic properties of imidazolium-, pyridinium-, pyrrolidinium-, and piperidinium-based ionic liquids

Gardas, RL; Costa, HF; Freire, MG; Carvalho, PJ; Marrucho, IM; Fonseca, IMA; Ferreira, AGM; Coutinho, JAP
2008, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 53, 3, 805-811.

Surface tensions for the 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ionic liquids

Carvalho, PJ; Freire, MG; Marrucho, IM; Queimada, AJ; Coutinho, JAP
2008, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 53, 6, 1346-1350.

Solubility of Water in Tetradecyltrihexylphosphonium-Based Ionic Liquids

Freire, MG; Carvalho, PJ; Gardas, RL; Santos, LMNBF; Marrucho, IM; Coutinho, JAP
2008, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 53, 10, 2378-2382.

Measurements and correlation of high-pressure densities of imidazolium-based ionic liquids

Tome, LIN; Carvalho, PJ; Freire, MG; Marrucho, IM; Fonseca, IMA; Ferreira, AGM; Coutinho, JAP; Gardas, RL
2008, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 53, 8, 1914-1921.

Mutual solubilities of water and the [C(n)mim][Tf(2)N] hydrophobic ionic liquids

Freire, MG; Carvalho, PJ; Gardas, RL; Marrucho, IM; Santos, LMNBF; Coutinho, JAP
2008, JOURNAL OF PHYSICAL CHEMISTRY B, 112, 6, 1604-1610.

Evaluation of COSMO-RS for the prediction of LLE and VLE of alcohols plus ionic liquids

Freire, MG; Santos, LMNBF; Marrucho, IM; Coutinho, JAP
2007, FLUID PHASE EQUILIBRIA, 255, 2, 167-178.

An overview of the mutual solubilities of water-imidazolium-based ionic liquids systems

Freire, MG; Santos, LMNBF; Fernandes, AM; Coutinho, JAP; Marrucho, IM
2007, FLUID PHASE EQUILIBRIA, 261, 1-2, 449-454.

Surface tensions of imidazolium based ionic liquids: Anion, cation, temperature and water effect

Freire, MG; Carvalho, PJ; Fernandes, AM; Marrucho, IM; Queimada, AJ; Coutinho, JAP
2007, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 314, 2, 621-630.

Modeling the liquid-liquid equilibria of water plus fluorocarbons with the cubic-plus-association equation of state

Oliveira, MB; Freire, MG; Marrucho, IM; Kontogeorgis, GM; Queimada, AJ; Coutinho, JAP
2007, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 46, 4, 1415-1420.

High-pressure densities and derived thermodynamic properties of imidazolium-based ionic liquids

Gardas, RL; Freire, MG; Carvalho, PJ; Marrucho, IM; Fonseca, IMA; Ferreira, AGM; Coutinho, JAP
2007, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 52, 1, 80-88.

P rho T measurements of imidazolium-based ionic liquids

Gardas, RL; Freire, MG; Carvalho, PJ; Marrucho, IM; Fonseca, IMA; Ferreira, AGM; Coutinho, JAP
2007, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 52, 5, 1881-1888.

Mutual Solubilities of water and hydrophobic ionic liquids

Freire, MG; Neves, CMSS; Carvalho, PJ; Gardas, RL; Fernandes, AM; Marrucho, IM; Santos, LMNBF; Coutinho, JAP
2007, JOURNAL OF PHYSICAL CHEMISTRY B, 111, 45, 13082-13089.

Surface tension measurements of imidazolium based ionic liquids

Carvalho, PJ; Freire, MG; Queimada, AJ; Marrucho, IM; Coutinho, JAP
2006, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 231.

Mutual solubilities between water and ionic liquids

Freire, MG; Carvalho, PJ; Dias, AMA; Queimada, AJ; Santos, LMNBF; Fernandes, AM; Marrucho, IM; Coutinho, JAP
2006, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 231.

Surface tension of liquid fluorocompounds

Freire, MG; Carvalho, PJ; Queimada, AJ; Marucho, IM; Coutinho, JAP
2006, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 51, 5, 1820-1824.

Enzymatic method for determining oxygen solubility in perfluorocarbon emulsions

Freire, MG; Dias, AMA; Coutinho, JAP; Coelho, MAZ; Marrucho, IM
2005, FLUID PHASE EQUILIBRIA, 231, 1, 109-113.

Aging mechanisms of perfluorocarbon emulsions using image analysis

Freire, MG; Dias, AMA; Coelho, MAZ; Coutinho, JAP; Marrucho, IM
2005, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 286, 1, 224-232.

Solubility of hexafluorobenzene in aqueous salt solutions from (280 to 340) K

Freire, MG; Razzouk, A; Mokbel, I; Jose, J; Marrucho, IM; Coutinho, JAP
2005, JOURNAL OF CHEMICAL AND ENGINEERING DATA, 50, 1, 237-242.

Solubility of oxygen in liquid perfluorocarbons

Dias, AMA; Freire, M; Coutinho, JAP; Marrucho, IM
2004, FLUID PHASE EQUILIBRIA, 222, 325-330.

Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications

Mara G. Freire
2016, 315, Berlin , Springer Berlin Heidelberg.
ISBN: 978-3-662-52875-4

Anti-Cancer Biosurfactants

In Springer (Eds.), Microbial Biosurfactants
Flávia F. Magalhães, João C. F. Nunes, Marília T. Araújo, Ana M. Ferreira, Mafalda R. Almeida, Mara G. Freire, Ana P. M. Tavares
2021, 159-196.
ISBN: 10.1007/978-981-15-6607-3_8

Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

In Bentham Science (Eds.), Recent Advances in Analytical Techniques Volume: 4
Ana P. M. Tavares, Márcia C. Neves, Tito Trindade and Mara G. Freire
2020, 58-93.
ISBN: 978-981-14-0510-5

Aqueous biphasic systems formed by cholinium-based ionic liquids and mixtures of polymers

In Rasmus Fehrmann, Catherine Santini (Eds.), Ionic Liquids: Synthesis, Properties, Technologies and Applications
Teresa B.V Dinis, Catarina M.S.S. Neves, Luís Barbosa, João A.P. Coutinho, Mara G. Freire
2019, 29-54, Berlin, Walter de Gruyter GmbH.
ISBN: 978-3-11-058201-7

Application of Ionic Liquids in Separation and Fractionation Processes

In Buxing Han and Tianbin Wu (Eds.), Green Chemistry and Chemical Engineering
Emanuel V. Capela, João A.P. Coutinho, Mara G. Freire
2019, 637-665, New York, NY, Springer.
ISBN: 978-1-4939-9059-7

Immobilization of Ionic Liquids, Types of Materials, and Applications

In Zhang S. (Eds.), Encyclopedia of Ionic Liquids
Augusto Q. Pedro, João A. P. Coutinho, Mara G. Freire
2019, Springer.
ISBN: 978-981-10-6739-6

Ionic Liquids and Deep Eutectic Solvents in the Field of Environmental Monitoring

In Płotka-Wasylka, Justyna, Namieśnik, Jacek (Eds.), Green Analytical Chemistry: Past, Present and Perspectives
Cardoso I.S., Pedro A.Q., Silvestre A.J.D., Freire M.G.
2019, 203-240, Singapore, Springer.
ISBN: 978-981-13-9104-0

Use of Nanomaterials in the Pretreatment of Water Samples for Environmental Analysis

In Bhat AH, Jawaid M, O Sulliman FE, Al-Kindy SM (Eds.), Nanomaterials for Healthcare, Energy and Environment
Bernardo S, Sousa ACA, Neves MC, Freire MG
2019, 103-142, Aveiro, Springer Nature.
ISBN: 978-981-13-9832-2

Application of Ionic Liquids in Separation and Fractionation Processes

In Robert A. Meyers (Eds.), Encyclopedia of Sustainability Science and Technology
Emanuel V. Capela, João A.P. Coutinho, Mara G. Freire
2018, 1-29, New York, USA, Springer.
ISBN: 978-1-4939-2493-6

Ionic Liquids in Bioseparation Processes

In Toshiyuki ItohYoon-Mo Koo (Eds.), Advances in biochemical engineering/biotechnology
Belchior D.C.V., Duarte I.F., Freire M.G.
2018, 1-29, Springer, Berlin.
ISBN: 978-3-030-23080-7

Monoclonal Antibodies – Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic Agents

In Atta-ur-Rahman (Eds.), Frontiers in Clinical Drug Research-Anti Infectives
Emanuel V. Capela, M. Raquel Aires-Barros, Mara G. Freire, Ana M. Azevedo
2017, 142-203, Sharjah, UAE, Bentham Science.
ISBN: 978-1-68108-488-6

Imunoglobulina Y (IgY): uma Alternativa Promissora aos Anticorpos de Mamíferos

In Manuel A. Coimbra (Eds.), Bioquímica e Bem-Estar
M. V. Quental, M. R. Almeida, J. Gomes, J. Resende,P. Domingues, M. G. Freire
2017, Lisboa, Edições Afrontamento.
ISBN: 978-972-36-1560-9

Aplicação de Sistemas Aquosos Bifásicos na Purificação de Biomoléculas

In Á. S. Lima and C. C. Santana (Eds.), Processos de Extração e Purificação de Biomoléculas
Á. S. Lima, N. S. O. Placido, R. L. S. França, I. O. A. Reis, M. M. Pereira, M. G. Freire
2017, Brazil, EDUNIT - Editora Universitária Tiradentes.

CHAPTER 8:Ionic Liquids as Efficient Tools for the Purification of Biomolecules and Bioproducts from Natural Sources

In Rafal Bogel-Lukasik (Eds.), Ionic Liquids in the Biorefinery Concept : Challenges and Perspectives
Matheus M. Pereira, João A. P. Coutinho and Mara G. Freire
2016, 227-257, Royal Society of Chemistry.
ISBN: 978-1-84973-976-4

Introduction to Ionic-Liquid-Based Aqueous Biphasic Systems (ABS)

In Mara G. Freire (Eds.), Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications
Mara G. Freire
2016, 1-25, Springer Berlin Heidelberg.
ISBN: 978-3-662-52875-4

Predicting the Thermodynamic Behavior of Water & Ionic Liquids Systems Using COSMO-RS

In Gaune-Escard M, Seddon K R (Eds.), Molten Salts and Ionic Liquids: Never the Twain?
Freire MG, Santos LMNBF, Marrucho IM, Coutinho JAP
2010, John Wiley & Sons, Inc..
ISBN: 978-0471773924

Separation of dyes with reversible aqueous biphasic systems

Ana Maria da Conceição Ferreira
2013, supervised by Ana M. Fernandes and Mara G. Freire.

Aeration and Extraction in Multiphase Biological Reactors

Mara Guadalupe Freire Martins Martins
2007, supervised by João Manuel da Costa Araújo Pereira Coutinho; Isabel Marrucho.

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