The role of lipophilicity in transmembrane anion transport

abstract

The transmembrane anion transport activity of a series of synthetic molecules inspired by the structure of tambjamine alkaloids can be tuned by varying the lipophilicity of the receptor, with carriers within a certain log P range performing best.

keywords

LIQUID-CHROMATOGRAPHY; CHLORIDE TRANSPORT; BINDING; BICARBONATE; RECEPTORS; MEMBRANES; ANALOGS

subject category

Chemistry

authors

Saggiomo, V; Otto, S; Marques, I; Felix, V; Torroba, T; Quesada, R

our authors

acknowledgements

The authors thank financial support from Consejeria de Educacion de la Junta de Castilla y Leon (project BU005B09), the Ministerio de Ciencia e Innovacion of Spain (project CTQ2009-12631-BQU and Ramon y Cajal contract (R.Q.)) and EU (COST Action CM1005

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