PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

  1. Home

abstract

Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.

keywords

MALARIA; DERIVATIVES; AGENTS

subject category

Biochemistry & Molecular Biology; Pharmacology & Pharmacy

authors

Perez, B; Teixeira, C; Albuquerque, IS; Gut, J; Rosenthal, PJ; Prudencio, M; Gomes, P

our authors

foto Cátia Teixeira

Cátia Teixeira

Post-doc Fellowship

Groups

Projects

HEDICIN - HEterocycle-DIpeptide-CINnamic acid conjugates as novel antimalarials (PTDC/QUI-QUI/116864/2010)
PTNMR - Portuguese Nuclear Magnetic Resonance Network (REDE/1517/RMN/2005)

acknowledgements

This work was mainly supported by Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) through project PTDC/QUI-QUI/116864/2010. Funding to CIQUP through the strategic project PEst-C/QUI/UI0081/2011 is also acknowledged to FCT. CT thanks FCT for post-doctoral grant SFRH/BPD/62967/2009. MP acknowledges FCT for grant PTDC/SAU-MII/099118/2008. ISA is hired under FCT grant PTDC/SAU-GMG/100313/2008. Thanks are due to FCT also for both the LC-MS and NMR facilities, respectively funded through projects CONC-REEQ/275/QUI and REDE/1517/RMN/2005. Antonio M. Mendes is acknowledged for his help with data analysis and presentation.

Share this project:

Related Publications

Publication Details

type
Journal Article
year
2012
journal
MEDCHEMCOMM
volume
3
publisher
ROYAL SOC CHEMISTRY
issn
2040-2503
issue
9
digital object identifier
10.1039/c2md20113e
web of science article identifier
WOS:000307902400020

Journal Metrics (JCR 2019)

Journal Impact Factor
2.807
Journal Impact Factor (5 yrs)
2.527
category normalized journal percentile
47.094

Citations

Social Interaction

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".


Privacy and Cookie Policy

Personal data

CICECO-Aveiro Institute of Materials respects your privacy, ensuring confidentiality of personal data you share with the institution through this way, not collecting any personal information about you without your consent, under the terms required by General Data Protection Regulations (RGPD).

The data collected in forms are intended exclusively for processing user requests and will not be used for any other purpose, always safeguarding their confidentiality, under the terms of the protection conferred by the aforementioned regulation.

The collection and processing of data is the responsibility of CICECO and its storage is properly protected, only authorized CICECO employees can access the information within the scope of their functions, always being clear in the respective collection forms the purposes for which they are intended. The remaining issues to be considered in this matter will be handled by the University of Aveiro in accordance with the regime established by the GDPR.

Cookies policy

Cookies are small files with alphanumeric information that are stored on your computer's hard drive by your browser and are intended to improve the user experience and enhance website navigation.

Collection and use of technical information

The cookies used on CICECO are anonymous, and no information about our users that allows their personal identification is stored in them.

The technical information recorded consists of:

  • iP (Internet Protocol) address of the visitor;
  • the type of internet browser used by the website visitor and the respective operating system used;
  • the date and time of the consultation;
  • the pages visited on the site and the documents downloaded
  • The technical information collected is used for statistical purposes only.

Cookies used

Session cookies

These cookies are used to record user preferences, such as the language in which websites are displayed or to maintain authenticated user sessions, and are automatically deleted when the browser is closed.

Persistent cookies

These cookies store information that is needed between sessions. For example, a persistent cookie is set to record that you have been made aware of the cookie policy so that the message regarding this policy is not shown again the next time you visit the website. This cookie remains on the computer until it reaches its expiry date or is deleted by the user.

Data protection

The present privacy policy covers the Information System of the University of Aveiro (SIUA), governed by the General Data Protection Regulations (RGPD) Regulation (EU) No. 2016/679, of April 27th, 2016.

Data Protection Officer

The University of Aveiro has a Data Protection Officer (DPO), who ensures compliance of the processing of personal data with the legislation in force, and is available through the following email address epd@ua.pt.

Close