abstract
Burns present major impacts worldwide which stimulate the search for therapeutic alternatives, and the herbal medicines with anti-inflammatory and healing properties are potential targets. In the present study, we evaluated topical treatments with Lavandula officinalis essential oil (EO) and Arctium lappa extract in a second degree burn model. Wistar rats were anesthetized and submitted to thermal burns. The lesions were treated 2x/day with a cream containing 0.5% of L. officinalis EO plus 10% of A. lappa extract. Healing process evolution was evaluated on days 3, 7, 14, 21 and 30 after burns. Macroscopical and histopathological analyses showed more discreet edema and better reepithelialization in herbal treated animals. Higher expression of epidermal growth factor receptor in all phases of wound healing and lower expression of matrix metalloproteinases 2 and 9 especially at remodeling stages were observed in treated animals. Phytotherapic treatment reduced levels of interleukin-1_ and tumor necrosis factor-_ in scar tissues after 30 days. Aspartate aminotransferase levels were also decreased in herbal-treated animals. Our data showed better healing in animals treated with L. officinalis EO in association with A. lappa extract, pointing these phytotherapics as strategies for skin burns treatment.
authors
Ces‡rio, J. C. B., Prette, I. B., Forgerini, I., Santis, R. M. De, Iyomasa-Pilon, M. M., Glad, B. G., da Silva, G. P. R., Souza, H. R. Possebon, L., Pereira, M. L. G., Moreno, A. H. and Girol, A. P.
our authors
