Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

abstract

Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce photo-toxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).

keywords

THERAPY; CANCER; SYSTEM; PHOTOSENSITIZERS; RECEPTOR; ANALOGS

subject category

Chemistry

authors

Venkatramaiah, N; Pereira, PMR; Paz, FAA; Ribeiro, CAF; Fernandes, R; Tome, JPC

our authors

acknowledgements

Thanks are due to FCT/MEC for the financial support, to the QOPNA research Unit (FCT UID/QUI/00062/2013), IBILI research Unit (FCT UID/NEU/04539/2013) and CICECO-Aveiro Institute of Materials (FCT UID/CTM/50011/2013), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement, and also to the Portuguese NMR Network. We further wish to thank FCT for funding the R&D project (EXPL/CTM-NAN/0013/2013; FCOMP-01-0124-FEDER-041282). The authors also acknowledge FCT for the post-doctoral and doctoral research grants SFRH/BPD/79000/2011 (to NVR) and SFRH/BD/85941/2012 (to PMRP), respectively.

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