CICECO » Iola Melissa Fernandes Duarte

Short CV

Iola F. Duarte (born 1975) is a Principal Researcher at CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro (UA), since April 2015. She has a first degree in Biochemistry & Food Chemistry (1997), and a PhD in Chemistry (2003) from the University of Aveiro, having worked as a post-doctoral fellow in joint projects between CICECO/UA and Imperial College of London (2003-2006) / Faculty of Medicine, University of Coimbra (2006-2007). In 2007, Duarte was awarded the Prize L’Oréal PT for Women in Science and, in 2010, she was the recipient of the Portuguese League Against Cancer grant. Since 2007, she was awarded 4 research positions within competitive international calls (2 as Principal Researcher).

Duarte’s major domain of specialization is in the use of advanced analytical techniques for the comprehensive metabolic profiling (metabolomics) of biological samples (cells, tissues and biofluids) and the study of metabolism changes as a function of external stimuli or pathophysiological alteration. Presently, her main research interests comprise i) metabolic rewiring and modulation of innate immune cells in the context of chronic inflammation; ii) tumour metabolism and metabolic interactions in the tumour microenvironment; iii) anti-cancer and immunomodulatory activity of phytochemicals and nanomaterials.

I.F. Duarte published more than 80 papers, 75% in Q1 Journals, with > 2900 citations (h-index 32, source: Scopus). She is also (co)author of 10 book chapters and over 140 conference abstracts. Additionally, I.F. Duarte has delivered 23 talks by invitation, 8 at International conferences and 15 at National meetings, and 10 oral communications (call for participation) at International meetings. She has coordinated 6 research projects with competitive funding (1 ongoing) and has participated as team member in 10 other projects (4 ongoing). She is a UA representative in a Collaboration Agreement with Bruker BioSpin and in two European Inter-Laboratory Comparisons (2014, 2016). I.F. Duarte has supervised 3 post-doctoral researchers, 11 PhD students (6 ongoing), 14 MSc students (2 ongoing), 19 undergraduates (1 ongoing) and 5 Scientific Initiation grantees. She has also hosted 4 researchers/students from foreign Universities within the Erasmus+ Programme and she has been awarded an Invited Professor position at the University of Bari to teach a Metabolomics Course (Oct-Nov 2019). Additionally, I.F. Duarte has been active in organizing scientific events, participating in Juris and evaluation panels, acting as Guest Editor, Editorial Board member and Reviewer for several Journals and promoting science dissemination.

In regard to teaching experience, Duarte has been Invited Assistant Professor at the Health Sciences Department (UA) between 2007 and 2010, and, since 2011, she has collaborated in the teaching of several curricular units at the Chemistry Department (UA), to both undergraduate and post-graduate students, mainly in the fields of Biochemistry, Macromolecular Chemistry and Metabolomics.

Scientific Interests

- Metabolic rewiring and modulation of innate immune cells in the context of chronic inflammation.

- Tumour metabolism and metabolic interactions in the tumour microenvironment.

- Anti-cancer and immunomodulatory activity of phytochemicals and nanomaterials.

- NMR spectroscopy and metabolomics.

Present Research Group

PhD students: Ana Sofia Dias, Beatriz Ferreira, Gustavo Silva, Luís Mendes, Matias Cardoso, Tatiana Silva

MSc students: Carlota Silva, Gonçalo Amador

Teaching Activity

Biomoléculas, First Degree in Biomedical Sciences, Department of Medical Sciences, UA.

Bioquímica I, First Degrees in Biochemistry and Biotechnology, Department of Chemistry, UA.

Química Macromolecular, MSc Course in Chemistry, Department of Chemistry, UA.

Proteómica e Metabolómica, MSc Courses in Biochemistry and Biotechnology, UA.

Nutrição e Dietética, First Degree in Gerontology, Health School, UA.

Laboratório MH1, First Degree in Biomedical Sciences, Health Sciences Department, UA.

R&D projects

Principal Investigator (PI)

- ATHEROFIT: Phytochemical-based metabolic immunomodulation to prevent/attenuate particulate matter-mediated atherosclerosis, Ref. OHM-Estarreja/2019-2128, 2019-2021, financing: LabEx DRIIHM, Device for Interdisciplinary Research on Human-Environments Interactions.

- Impact of silk-based nanomedicines on the cellular metabolome, Ref. 12101 DD1720 RDF Grant 1715, 2016-2018, financing: Research and Development Grant from the University of Strathclyde.

- Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials, Ref. PTDC/SAU-TOX/120953/2010, 2012-2015, financing: FCT.

- Metabolomic study of lung cancer: metabolic signatures in tissues and biofluids, Ref. CIMAGO 04/12, 2013-2015, financing: CIMAGO, Faculty of Medicine of Coimbra (FMUC), PT.

- Metabolic profiling and biochemical differentiation of human lung tumours by Nuclear Magnetic Resonance (NMR) methods, Ref. PTDC/QUI/68017/2006, 2008-2011, financing: FCT.

- Biochemical characterisation of stomach, endometrial and lung tumour tissues by High Resolution Magic Angle Spinning (HRMAS) Nuclear Magnetic Resonance (NMR) spectroscopy, Ref. CIMAGO 14/06, 2006-2009, financing: CIMAGO (FMUC), PT.

Team member

- BIOIMPLANT: A Metabolomics-guided Bioreactor for Improved Bone Engineered Implants, Ref. POCI-01-0145-FEDER-031498, 2018-2021, financing: FCT.

- HOTsPOT: Novel upconversion nanoparticles for multimodal therapy of melanoma: photothermal therapy, photodynamic therapy and chemotherapy, Ref. POCI-01-0145-FEDER-031794, 2018-2021, financing: FCT.

- REFINECYANO: Using biorefinery to value cyanobateria pigments, Ref. POCI-01-0145-FEDER-030914, 2018-2021, financing: FCT.

- Biomaterials for Regenerative Medicine, Ref. SCT-2011-02-030-4872, 2013-2015, financing: PORC-MaisCentro.

- New Valorization Strategies for Eucalyptus spp. Bark Extracts, Ref. PTDC/AGR-FOR/3187/2012, 2013-2015, financing: FCT.

- Search for new markers of therapy response in lung cancer, Ref. CIMAGO 03/12, 2013-2015, funding CIMAGO (FMUC), PT.

- Future asthma management helped by non-invasive sampling: contributes for the definition of a rapid and non-invasive diagnostic tool, Ref. PTDC/QUI-QUI/117803/2010, 2012-2015, financing: FCT.

- A Nuclear Magnetic Resonance (NMR)-based metabonomic study of health disorders of fetus and mother during pregnancy: towards biochemical characterisation and early diagnostics, Ref. PTDC/QUI/66523/2006, 2008-2011, financing: FCT.

- Implantable scaffolds for local osteossarcoma chemotherapy, Ref. PTDC/SAU-BEB/66896/2006, 2007-2010, financing: FCT.

Selected Publications

Calmeiro J, Mendes L, Duarte IF, Leitão C, Tavares AR, Ferreira DA, Gomes C, Serra J, Falcão A, Cruz MT, Carrascal MA, Neves BM. In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy. Frontiers in Immunology 2021, 11:593363.

Guerra ÂR, Soares BIG, Freire CSR, Silvestre AJD, Duarte MF, Duarte IF. Metabolic Effects of a Eucalyptus Bark Lipophilic Extract on Triple Negative Breast Cancer and Nontumor Breast Epithelial Cells. Journal of Proteome Research 2021, 20(1):565-575.

Guerra ÂR, Paulino AF, Castro MM, Oliveira H, Duarte MF, Duarte IF. Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids. Biomolecules 2020, 10(8):1163.

Conde TA, Mendes L, Gaspar VM, Mano JF, Melo T, Domingues MR, Duarte IF. Differential Modulation of the Phospholipidome of Proinflammatory Human Macrophages by the Flavonoids Quercetin, Naringin and Naringenin. Molecules 2020, 25(15):3460.

Cicuéndez M, Fernandes M, Ayán-Varela M, Oliveira H, Feito MJ, Diez-Orejas R, Paredes JI, Villar-Rodil S, Vila M, Portolés MT, Duarte IF. Macrophage inflammatory and metabolic responses to graphene-based nanomaterials differing in size and functionalization. Colloids and Surfaces B: Biointerfaces 2020, 186:110709.

Mendes LF, Gaspar VM, Conde TA, Mano JF, Duarte IF. Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways. Scientific Reports 2019, 9(1):14906.

Totten J, Wongpinyochit T, Carrola J, Duarte IF, Seib FP. PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles. ACS Applied Materials & Interfaces 2019, 11(16):14515-14525.

Dias AS, Almeida CR, Helguero LA, Duarte IF. Metabolic crosstalk in the breast cancer microenvironment. European Journal of Cancer 2019, 121:154-171.

Cicuéndez M, Flores J, Oliveira H, Portolés MT, Vallet-Regí M, Vila M, Duarte IF. Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia. Materials Science and Engineering: C 2018, 91:340-348.

Carrola J, Pinto RJB, Nasirpour M, Freire CSR, Gil AM, Santos C, Oliveira H, Duarte IF. NMR metabolomics reveals metabolism-mediated protective effects in liver (HepG2) cells exposed to subtoxic levels of silver nanoparticles. Journal of Proteome Research 2018, 17:1636-1646.

Guerra AR, Duarte MF, Duarte IF. Targeting tumor metabolism with plant-derived natural products: emerging trends in cancer therapy. Journal of Agricultural and Food Chemistry 2018, 41, 10663-10685.

Arminan A, Mendes L, Carrola J, Movellan J, Vicent MJ, Duarte IF. HIF-1a inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: Insights from NMR metabolomics. Journal of Drug Targeting 2017, 25, 845-855.

Jarak I, Carrola J, Barros AS, Gil AM, Pereira ML, Corvo ML, Duarte IF. Metabolism modulation in different organs by silver nanoparticles: an NMR metabolomics study of a mouse model. Toxicological Sciences 2017, 159:422–435.

Saborano R, Wongpinyochit T, Totten JD, Johnston BF, Seib FP, Duarte IF. Metabolic reprogramming of macrophages exposed to silk, poly(lactic-co-glycolic acid) and silica nanoparticles. Advanced Healthcare Materials 2017, 6:1601240.

Carrola J, Bastos V, Jarak I, Oliveira-Silva R, Malheiro E, Daniel-da-Silva AL, Oliveira H, Santos C, Gil AM, Duarte IF. Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure–activity relationships and role of ionic silver and oxidative stress. Nanotoxicology 2016, 10:1105-1117.

main active international collaborations

- Ciro Leonardo Pierri, Department of Biosciences, Biotechnologies and Biopharmaceutics, Università degli Studi di Bari Aldo Moro, Italy.

- Elena Ciani, Department of Biosciences, Biotechnologies and Biopharmaceutics, Università degli Studi di Bari Aldo Moro, Italy.

- Eneida de Paula, Department of Biochemistry and Tissue Biology, Universidade Estadual de Campinas (UNICAMP), Brasil.

- Flaminia Cesare Marincola, Department of Chemical and Geological Sciences, University of Cagliari, Italy.

- Gustavo Goldman, School of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo, Brasil.

- María Teresa Portolés, Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, Spain.

- Peter Hoet, Department of Public Health and Primary Care, KU Leuven, Belgium.

- Philipp Seib, Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK.

- Raquel Moral Cabrera, Department of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Spain.

- Winfried Neuhaus, Center Health & Bioresources, AIT Austrian Institute of Technology, Austria.

Projects

Publications

A Contribution to the Harmonization of Non-targeted NMR Methods for Data-Driven Food Authenticity Assessment

Gallo, V; Ragone, R; Musio, B; Todisco, S; Rizzuti, A; Mastrorilli, P; Pontrelli, S; Intini, N; Scapicchio, P; Triggiani, M; Pascazio, A; Cobas, C; Mari, S; Garino, C; Arlorio, M; Acquotti, D; Airoldi, C; Arnesano, F; Assfalg, M; Barison, A; Benevelli, F; Borioni, A; Cagliani, LR; Casadei, L; Marincola, FC; Colson, K; Consonni, R; Costantino, G; Cremonini, MA; Davalli, S; Duarte, I; Guyader, S; Hamon, E; Hegmanns, M; Lamanna, R; Longobardi, F; Mallamace, D; Mammi, S; Markus, M; Menezes, LRA; Milone, S; Molero-Vilchez, D; Mucci, A; Napoli, C; Rossi, MC; Saez-Barajas, E; Savorani, F; Schievano, E; Sciubba, F; Sobolev, A; Takis, PG; Thomas, F; Villa-Valverde, P; Latronico, M
2020, FOOD ANALYTICAL METHODS, 13, 2, 530-541.
ISBN: 1936-976X

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7

Gutschow, M; Vanden Eynde, JJ; Jampilek, J; Kang, CB; Mangoni, AA; Fossa, P; Karaman, R; Trabocchi, A; Scott, PJH; Reynisson, J; Rapposelli, S; Galdiero, S; Winum, JY; Brullo, C; Prokai-Tatrai, K; Sharma, AK; Schapira, M; Azuma, YT; Cerchia, L; Spetea, M; Torri, G; Collina, S; Geronikaki, A; Garcia-Sosa, AT; Vasconcelos, MH; Sousa, ME; Kosalec, I; Tuccinardi, T; Duarte, IF; Salvador, JAR; Bertinaria, M; Pellecchia, M; Amato, J; Rastelli, G; Gomes, PAC; Guedes, RC; Sabatier, JM; Estevez-Braun, A; Pagano, B; Mangani, S; Ragno, R; Kokotos, G; Brindisi, M; Gonzalez, FV; Borges, F; Miloso, M; Rautio, J; Munoz-Torrero, D
2020, MOLECULES, 25, 13.
ISBN: 1420-3049

Macrophage inflammatory and metabolic responses to graphene-based nanomaterials differing in size and functionalization

Cicuendez, M; Fernandes, M; Ayan-Varela, M; Oliveira, H; Feito, MJ; Diez-Orejas, R; Paredes, JI; Villar-Rodil, S; Vila, M; Portoles, MT; Duarte, IF
2020, COLLOIDS AND SURFACES B-BIOINTERFACES, 186.
ISBN: 1873-4367

Macrophage Metabolomics Reveals Differential Metabolic Responses to Subtoxic Levels of Silver Nanoparticles and Ionic Silver

Carrola, J; Bastos, V; Daniel-da-Silva, AL; Gil, AM; Santos, C; Oliveira, H; Duarte, IF
2020, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2020, 19, 1867-1876.
ISBN: 1099-0682

Performance of tetraalkylammonium-based ionic liquids as constituents of aqueous biphasic systems in the extraction of ovalbumin and lysozyme

Belchior, DCV; Quental, MV; Pereira, MM; Mendonca, CMN; Duarte, IF; Freire, MG
2020, SEPARATION AND PURIFICATION TECHNOLOGY, 233.
ISBN: 1873-3794

Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids

Guerra, AR; Paulino, AF; Castro, MM; Oliveira, H; Duarte, MF; Duarte, IF
2020, BIOMOLECULES, 10, 8.
ISBN: 2218-273X

Differential Modulation of the Phospholipidome of Proinflammatory Human Macrophages by the Flavonoids Quercetin, Naringin and Naringenin

Conde, TA; Mendes, L; Gaspar, VM; Mano, JF; Melo, T; Domingues, MR; Duarte, IF
2020, MOLECULES, 25, 15.
ISBN: 1420-3049

Odd-Even Effect in the Formation and Extraction Performance of Ionic-Liquid-Based Aqueous Biphasic Systems

Belchior, DCV; Almeida, MR; Sintra, TE; Ventura, SPM; Duarte, IF; Freire, MG
2019, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 58, 19, 8323-8331.

PEGylation-Dependent Metabolic Rewiring of Macrophages with Silk Fibroin Nanoparticles

Totten, JD; Wongpinyochit, T; Carrola, J; Duarte, IF; Seib, FP
2019, ACS APPLIED MATERIALS & INTERFACES, 11, 16, 14515-14525.
ISBN: 1944-8252

Metabolic crosstalk in the breast cancer microenvironment

Dias, AS; Almeida, CR; Helguero, LA; Duarte, IF
2019, EUROPEAN JOURNAL OF CANCER, 121, 154-171.
ISBN: 1879-0852

Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways

Mendes, LF; Gaspar, VM; Onde, TAC; Mano, JF; Duarte, IF
2019, SCIENTIFIC REPORTS, 9.

Development of a novel dendritic cell-based immunotherapy targeting cancer stem cells.

Calmeiro, J; Carrascal, M; Mendes, L; Duarte, IF; Gomes, C; Serra, J; Falcao, A; Cruz, MT; Neves, BM
2019, JOURNAL OF CLINICAL ONCOLOGY, 37, 15.
ISBN: 1527-7755

Ionic Liquids in Bioseparation Processes

Belchior, DCV; Duarte, IF; Freire, MG
2019, APPLICATION OF IONIC LIQUIDS IN BIOTECHNOLOGY, 168, 1-29.
ISBN: 1616-8542

NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles

Carrola, J; Pinto, RJB; Nasirpour, M; Freire, CSR; Gil, AM; Santos, C; Oliveira, H; Duarte, IF
2018, JOURNAL OF PROTEOME RESEARCH, 17, 4, 1636-1646.

Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia

Cicuendez, M; Flores, J; Oliveira, H; Portoles, MT; Vallet-Regi, M; Vila, M; Duarte, IF
2018, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 91, 340-348.

Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy

Guerra, AR; Duarte, MF; Duarte, IF
2018, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66, 41, 10663-10685.

Impact of the Pd(2)Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

Lamego, I; Marques, MPM; Duarte, IF; Martins, AS; Oliveira, H; Gil, AM
2017, JOURNAL OF PROTEOME RESEARCH, 16, 4, 1773-1783.
ISBN: 1535-3907

From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model

Jarak, I; Carrola, J; Barros, AS; Gil, AM; Pereira, MD; Corvo, ML; Duarte, IF
2017, TOXICOLOGICAL SCIENCES, 159, 2, 422-435.
ISBN: 1096-0929

Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic-co-glycolic acid), and Silica Nanoparticles

Saborano, R; Wongpinyochit, T; Totten, JD; Johnston, BF; Seib, FP; Duarte, IF
2017, ADVANCED HEALTHCARE MATERIALS, 6, 14.
ISBN: 2192-2659

A study of the effects of citrate-coated silver nanoparticles on RAW 264.7 cells using a toolbox of cytotoxic endpoints

Bastos, V; Duarte, IF; Santos, C; Oliveira, H
2017, JOURNAL OF NANOPARTICLE RESEARCH, 19, 5.
ISBN: 1572-896X

Genotoxicity of citrate-coated silver nanoparticles to human keratinocytes assessed by the comet assay and cytokinesis blocked micronucleus assay

Bastos, V; Duarte, IF; Santos, C; Oliveira, H
2017, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 24, 5, 5039-5048.
ISBN: 1614-7499

Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line

Bastos, V; Ferreira-de-Oliveira, JMP; Carrola, J; Daniel-da-Silva, AL; Duarte, IF; Santos, C; Oliveira, H
2017, JOURNAL OF ENVIRONMENTAL SCIENCES, 51, 191-201.
ISBN: 1878-7320

HIF-1 alpha inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics

Arminan, A; Mendes, L; Carrola, J; Movellan, J; Vicent, MJ; Duarte, IF
2017, JOURNAL OF DRUG TARGETING, 25, 09-Oct, 845-855.

Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics

Carrola, J; Bastos, V; de Oliveira, JMPF; Oliveira, H; Santos, C; Gil, AM; Duarte, IF
2016, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 589, 53-61.

Inflammatory responses of a human keratinocyte cell line to 10 nm citrate- and PEG-coated silver nanoparticles

Bastos, V; Brown, D; Johnston, H; Daniel-da-Silva, AL; Duarte, IF; Santos, C; Oliveira, H
2016, JOURNAL OF NANOPARTICLE RESEARCH, 18, 7.

Metabolic responses of the isopod Porcellionides pruinosus to nickel exposure assessed by H-1 NMR metabolomics

Ferreira, NGC; Saborano, R; Morgado, R; Cardoso, DN; Rocha, CM; Soares, AMVM; Loureiro, S; Duarte, IF
2016, JOURNAL OF PROTEOMICS, 137, 59-67.

Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure-activity relationships and role of ionic silver and oxidative stress

Carrola, J; Bastos, V; Jarak, I; Oliveira-Silva, R; Malheiro, E; Daniel-da-Silva, AL; Oliveira, H; Santos, C; Gil, AM; Duarte, IF
2016, NANOTOXICOLOGY, 10, 8, 1105-1117.

Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challenges

Guerra, AR; Duarte, IF; Duarte, MF
2016, CURRENT MEDICINAL CHEMISTRY, 23, 9, 911-928.

The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line

Bastos, V; de Oliveira, JMPF; Brown, D; Jonhston, H; Malheiro, E; Daniel-da-Silva, AL; Duarte, IF; Santos, C; Oliveira, H
2016, TOXICOLOGY LETTERS, 249, 29-41.

Microscopic studies of liver and kidney in mice exposed to silver nanoparticles

Maral R., Carrola J., Jarak I., Luisa Corvo M., Duarte I.F., De Lourdes Pereira M.
2016, Microscopy and Microanalysis, 22, 18-19.

NMR metabolomics of renal cancer: an overview

Gil, AM; de Pinho, PG; Monteiro, MS; Duarte, IF
2015, BIOANALYSIS, 7, 18, 2361-2374.

NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma

Rocha, CM; Barros, AS; Goodfellow, BJ; Carreira, IM; Gomes, A; Sousa, V; Bernardo, J; Carvalho, L; Gil, AM; Duarte, IF
2015, CARCINOGENESIS, 36, 1, 68-75.

Different responses of young and expanded lettuce leaves to fungicide Mancozeb: chlorophyll fluorescence, lipid peroxidation, pigments and proline content

Dias, MC; Figueiredo, P; Duarte, IF; Gil, AM; Santos, C
2014, PHOTOSYNTHETICA, 52, 1, 148-151.

NMR metabolomics of human blood and urine in disease research

Duarte, IF; Diaz, SO; Gil, AM
2014, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 93, 17-26.

Metabolic Markers of MG-63 Osteosarcoma Cell Line Response to Doxorubicin and Methotrexate Treatment: Comparison to Cisplatin

Lamego, I; Duarte, IF; Marques, MPM; Gil, AM
2014, JOURNAL OF PROTEOME RESEARCH, 13, 12, 6033-6045.

Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

Loureiro, CC; Duarte, IF; Gomes, J; Carrola, J; Barros, AS; Gil, AM; Bousquet, J; Bom, AT; Rocha, SM
2014, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133, 1, 261-263.

Changes in the metabolome of lettuce leaves due to exposure to mancozeb pesticide

Pereira, SI; Figueiredo, PI; Barros, AS; Dias, MC; Santos, C; Duarte, IF; Gil, AM
2014, FOOD CHEMISTRY, 154, 291-298.

Second Trimester Maternal Urine for the Diagnosis of Trisomy 21 and Prediction of Poor Pregnancy Outcomes

Diaz, SO; Barros, AS; Goodfellow, BJ; Duarte, IF; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2013, JOURNAL OF PROTEOME RESEARCH, 12, 6, 2946-2957.

Mid-infrared (MIR) metabolic fingerprinting of amniotic fluid: A possible avenue for early diagnosis of prenatal disorders?

Graca, G; Moreira, AS; Correia, AJV; Goodfellow, BJ; Barros, AS; Duarte, IF; Carreira, IM; Galhano, E; Pita, C; Almeida, MD; Gil, AM
2013, ANALYTICA CHIMICA ACTA, 764, 24-31.

Following Healthy Pregnancy by Nuclear Magnetic Resonance (NMR) Metabolic Profiling of Human Urine

Diaz, SO; Barros, AS; Goodfellow, BJ; Duarte, IF; Carreira, IM; Galhano, E; Pita, C; Almeida, MD; Gil, AM
2013, JOURNAL OF PROTEOME RESEARCH, 12, 2, 969-979.

Potential Markers of Cisplatin Treatment Response Unveiled by NMR Metabolomics of Human Lung Cells

Duarte, IF; Ladeirinha, AF; Lamego, I; Gil, AM; Carvalho, L; Carreira, IM; Melo, JB
2013, MOLECULAR PHARMACEUTICS, 10, 11, 4242-4251.

Metabolic response of human keratinocytes to silver nanoparticles: A metabolomics study

Carrola, J; Gil, AM; Silva, ALD; Bastos, V; Oliveira, H; Oliveira, JMPF; Santos, C; Duarte, IF
2013, TOXICOLOGY LETTERS, 221, S242-S243.

Metabolic profiling of biofluids: potential in lung cancer screening and diagnosis

Duarte, IF; Rocha, CM; Gil, AM
2013, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 13, 7, 737-748.

Remodeling of liver phospholipidomic profile in streptozotocin-induced diabetic rats

Simoes, C; Domingues, P; Ferreira, R; Amado, F; Duarte, JA; Vitorino, R; Neuparth, MJ; Nunes, C; Rocha, C; Duarte, I; Domingues, MR
2013, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 538, 2, 95-102.

Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry

Rocha, SM; Caldeira, M; Carrola, J; Santos, M; Cruz, N; Duarte, IF
2012, JOURNAL OF CHROMATOGRAPHY A, 1252, 155-163.

Metabolic signatures of cancer unveiled by NMR spectroscopy of human biofluids

Duarte, IF; Gil, AM
2012, PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 62, 51-74.

UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers

Graca, G; Goodfellow, BJ; Barros, AS; Diaz, S; Duarte, IF; Spagou, K; Veselkov, K; Want, EJ; Lindon, JC; Carreira, IM; Galhano, E; Pita, C; Gil, AM
2012, MOLECULAR BIOSYSTEMS, 8, 4, 1243-1254.

Can Biofluids Metabolic Profiling Help to Improve Healthcare during Pregnancy?

Graca, G; Diaz, SO; Pinto, J; Barros, AS; Duarte, IF; Goodfellow, BJ; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
2012, SPECTROSCOPY-AN INTERNATIONAL JOURNAL, 27, 5-6, 515-523.

Monitoring pregnancy and prenatal disorders through NMR metabolic profiling of maternal blood plasma

Pinto, J; Barros, AS; Duarte, IF; Goodfellow, BJ; Galhano, E; Pita, C; Carreira, IM; Almeida, MD; Gil, AM
2012, FEBS JOURNAL, 279, 406-406.

Lung cancer metabolic signatures unveiled by metabonomics

Rocha, CM; Carrola, J; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, S48-S48.

Following dynamic biological processes through NMR-based metabonomics: A new tool in nanomedicine?

Duarte, IF
2011, JOURNAL OF CONTROLLED RELEASE, 153, 1, 34-39.

Biocellulose Membranes as Supports for Dermal Release of Lidocaine

Trovatti, E; Silva, NHCS; Duarte, IF; Rosado, CF; Almeida, IF; Costa, P; Freire, CSR; Silvestre, AJD; Neto, CP
2011, BIOMACROMOLECULES, 12, 11, 4162-4168.

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine

Carrola, J; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, JOURNAL OF PROTEOME RESEARCH, 10, 1, 221-230.

Metabolic Biomarkers of Prenatal Disorders: An Exploratory NMR Metabonomics Study of Second Trimester Maternal Urine and Blood Plasma

Diaz, SO; Pinto, J; Graca, G; Duarte, IF; Barros, AS; Galhano, E; Pita, C; Almeida, MD; Goodfellow, BJ; Carreira, IM; Gil, AM
2011, JOURNAL OF PROTEOME RESEARCH, 10, 8, 3732-3742.

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma

Rocha, CM; Carrola, J; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2011, JOURNAL OF PROTEOME RESEARCH, 10, 9, 4314-4324.

Lung tumors' biomarker profiles of malignancy and histological type assessed by nuclear magnetic resonance (NMR) spectroscopy

Carvalho, LM; Duarte, IF; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Gomes, AI; Oliveira, DM; Sousa, VM; Bernardo, J
2010, HISTOPATHOLOGY, 57, 226-226.

Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours?

Duarte, IF; Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Carreira, IM; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L
2010, VIRCHOWS ARCHIV, 457, 6, 715-725.

Nuclear Magnetic Resonance (NMR) Study of the Effect of Cisplatin on the Metabolic Profile of MG-63 Osteosarcoma Cells

Duarte, IF; Lamego, I; Marques, J; Marques, MPM; Blaise, BJ; Gil, AM
2010, JOURNAL OF PROTEOME RESEARCH, 9, 11, 5877-5886.

Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study

Graca, G; Duarte, IF; Barros, AS; Goodfellow, BJ; Diaz, SO; Pinto, J; Carreira, IM; Galhano, E; Pita, C; Gil, AM
2010, JOURNAL OF PROTEOME RESEARCH, 9, 11, 6016-6024.

Metabolic Profiling of Human Lung Cancer Tissue by H-1 High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy

Rocha, CM; Barros, AS; Gil, AM; Goodfellow, BJ; Humpfer, E; Spraul, M; Carreira, IM; Melo, JB; Bernardo, J; Gomes, A; Sousa, V; Carvalho, L; Duarte, IF
2010, JOURNAL OF PROTEOME RESEARCH, 9, 1, 319-332.

Analytical Approaches toward Successful Human Cell Metabolome Studies by NMR Spectroscopy

Duarte, IF; Marques, J; Ladeirinha, AF; Rocha, C; Lamego, I; Calheiros, R; Silva, TM; Marques, MPM; Melo, JB; Carreira, IM; Gil, AM
2009, ANALYTICAL CHEMISTRY, 81, 12, 5023-5032.

H-1 NMR Based Metabonomics of Human Amniotic Fluid for the Metabolic Characterization of Fetus Malformations

Graca, G; Duarte, IF; Barros, AS; Goodfellow, BJ; Diaz, S; Carreira, IM; Couceiro, AB; Galhano, E; Gil, AM
2009, JOURNAL OF PROTEOME RESEARCH, 8, 8, 4144-4150.

Identification of metabolites in human hepatic bile using 800 MHz H-1 NMR spectroscopy, HPLC-NMR/MS and UPLC-MS

Duarte, IF; Legido-Quigley, C; Parker, DA; Swann, JR; Spraul, M; Braumann, U; Gil, AM; Holmes, E; Nicholson, JK; Murphy, GM; Vilca-Melendez, H; Heatond, N; Lindon, JC
2009, MOLECULAR BIOSYSTEMS, 5, 2, 180-190.

NMR metabonomics for mammalian cell metabolism studies

Duarte, IF; Lamego, I; Rocha, C; Gil, AM
2009, BIOANALYSIS, 1, 9, 1597-1614.

Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy

Graca, G; Duarte, IF; Goodfellow, BJ; Carreira, IM; Couceiro, AB; Domingues, MD; Spraul, M; Tseng, LH; Gil, AM
2008, ANALYTICAL CHEMISTRY, 80, 15, 6085-6092.

Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution H-1 NMR spectroscopy

Duarte, IF; Goodfellow, BJ; Barros, A; Jones, JG; Barosa, C; Diogo, L; Garcia, P; Gill, AM
2007, NMR IN BIOMEDICINE, 20, 4, 401-412.

Metabolic profiling of liver from hypercholesterolemic pigs fed rye or wheat fiber and from normal pigs. High-resolution magic angle spinning H-1 NMR spectroscopic study

Bertram, HC; Duarte, IF; Gil, AM; Knudsen, KEB; Laerke, HN
2007, ANALYTICAL CHEMISTRY, 79, 1, 168-175.

Potential of NMR Spectroscopy for the study of human amniotic fluid

Graca, G; Duarte, IF; Goodfellow, BJ; Barros, AS; Carreira, IM; Couceiro, AB; Spraul, M; Gil, AM
2007, ANALYTICAL CHEMISTRY, 79, 21, 8367-8375.

Study of natural mango juice spoilage and microbial contamination with Penicillium expansum by high resolution H-1 NMR spectroscopy

Duarte, IF; Delgadillo, I; Gil, AM
2006, FOOD CHEMISTRY, 96, 2, 313-324.

Composition of beer by H-1 NMR spectroscopy: Effects of brewing site and date of production

Almeida, C; Duarte, IF; Barros, A; Rodrigues, J; Spraul, M; Gil, AM
2006, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54, 3, 700-706.

Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning H-1 NMR spectroscopy

Duarte, IF; Stanley, EG; Holmes, E; Lindon, JC; Gil, AM; Tang, HR; Ferdinand, R; McKee, CG; Nicholson, JK; Vilca-Melendez, H; Heaton, N; Murphy, GM
2005, ANALYTICAL CHEMISTRY, 77, 17, 5570-5578.

Characterization of mango juice by high-resolution NMR, hyphenated NMR, and diffusion-ordered spectroscopy

Duarte, IF; Goodfellow, BJ; Gil, AM; Delgadillo, I
2005, SPECTROSCOPY LETTERS, 38, 3, 319-342.

Application of NMR and hyphenated NMR spectroscopy for the study of beer components

Duarte, IF; Spraul, M; Godejohann, M; Braumann, U; Gil, AM
2003, MAGNETIC RESONANCE IN FOOD SCIENCE: LATEST DEVELOPMENTS, 286, 151-157.
ISBN: 0-85404-886-3

Iola Melissa Fernandes Duarte

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